Nearly every massive galaxy contains a supermassive black hole (BH) at its center. For decades, both theory and numerical simulations have indicated that BHs play a central role in regulating the growth and quenching of galaxies. Specifically, BH feedback by heating or blowing out the interstellar medium (ISM) serves as the groundwork for current models of massive galaxy formation. However, direct evidence for such an impact on the galaxy-wide ISM from BHs has only been found in some extreme objects. For general galaxy populations, it remains unclear whether and how BHs impact the ISM. Here based on a large sample of nearby galaxies with measurements of masses of both black holes and atomic hydrogen, the major component of cold ISM, we reveal that the atomic hydrogen content ( fHI = MHI/M*) is tightly and anti-correlated with black hole mass (M_BH) with f_HI ~M_BH^(-α) (α ∼ 0.5 − 0.6). This correlation is valid across five orders of magnitude in M_BH. Once this correlation is taken into account, fHI loses dependence on other galactic parameters, demonstrating that M_BH serves as the primary driver of fHI. These findings provide critical evidence for how the accumulated energy from BH accretion impacts galaxy-wide ISM, representing a crucial step forward in our understanding on the role of BHs in regulating the growth and quenching of massive galaxies.