The design and construction of nanodevices such as microbatteries, quantum cascade
lasers, field-effect transistors, light-emitting diodes, gas nanosensors, etc. rely critically on our ability to fabricate functional heterostructures and interfaces with desirable characteristics [1-3]. Fortunately, the development of nanomaterials has created great excitement and expectations in the field of nanodevices. Much progress in the synthesis, fabrication and assembly of nanomaterials has already been gained in the past decades. Especially, nanostructured semiconducting oxides have attracted much attention due to their tunable physical properties and wide applications. Various kinds of semiconducting oxides, such as TiO2 , ZnO , SiO2 , In2O3 , Ga2O3 , GeO2
, SnO2 , CdO , and PbO2  with different morphology have been
successfully prepared. Among them, TiO2 has been investigated mainly owing to its
widespread applications in lithium ion batteries , solar cells , photocatalysts
, and sensors . Most of the previous researches focused on the morphological controlling and property modulation of TiO2. The mechanical behavior of materials at
the nanoscale is often different from that at the macroscopic scale. Thus, the mechanical properties of nanomaterials are crucial to the development and processing of novel nanodevices [17, 18].
The challenge of research on nanomechanical properties is not only due to the lack of nanoscale experimental techniques, but also the lack of multiscale theories to describe the size effects . In recent years, in-situ transmission electron microscopy (TEM) and scanning electron microscopy (SEM) nanomechanical testing have been developed to image and measure the deformation inside the instruments [20-22]. Besides, atomic force microscopy (AFM) was employed to image and measure the deformation and applied force of the object simultaneously at the nanoscale [23-26]. As an open platform, AFM provides multiple possibilities for the mechanical characterization of nanomaterials. For example, the three-point bending test and nanoindentation were widely performed on AFM to measure Young’s modulus and hardness of nanostructures [24, 27, 28]. However, due to the lack of basic data and related experimental equipment, the finite element method (FEM) was widely employed to simulate and predict the mechanical properties of nanomaterials under complicated conditions[10, 25, 26, 29]. Herein, TiO2 nanotubes were synthesized from an
electrospun method combined with subsequent heat-treatment. A series of destructive and non-destructive tests were carried out to characterize the mechanical properties of a single TiO2 nanotube. The fracture strength of a single TiO2 nanotube was measured by
the AFM technology. The effect of elastic modulus and dimensional size on the
mechanical behaviors of the nanotubes was simulated by the FEM.