Formulation of traditional Chinese medicine and its application on intestinal flora of constipated rats
In this study, the self-extracted constipation treatment of traditional Chinese medicine extracts was applied to constipated rats. To explore the mechanism and role of the Chinese medicine for the treatment of constipation, the 16S rRNA sequencing and qRT-PCR technology were used to analyze the abundance and diversity of intestinal flora in rats. We found that the relative abundance of Firmicutes in the intestinal flora of rats with constipation was significantly higher than that in the control group, and the Bacteroides was significantly lower than that in the control group, while the relative abundance of Firmicutes was significantly changed after taking a certain dose of Chinese medicine, and reduced the relative abundance of Lachnospiraceae, and greatly increased the relative abundance of Lactobacillus, enhanced the symbiotic relationships of Lactobacillus with other intestinal flora. There was no significant difference in the total copies of intestinal bacteria between the constipated rats and the control group. The total copies of intestinal bacteria in the constipated rats decreased after taking the traditional Chinese medicine. Finally, this study results provides a theoretical basis for the treatment and understand the mechanism and effect of traditional Chinese medicine on rate constipation.
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Posted 22 Jun, 2020
On 18 Nov, 2020
Received 22 Jul, 2020
On 17 Jul, 2020
Received 07 Jul, 2020
Received 02 Jul, 2020
Received 02 Jul, 2020
On 01 Jul, 2020
On 01 Jul, 2020
Invitations sent on 23 Jun, 2020
On 23 Jun, 2020
On 19 Jun, 2020
On 18 Jun, 2020
On 18 Jun, 2020
On 15 Jun, 2020
Formulation of traditional Chinese medicine and its application on intestinal flora of constipated rats
Posted 22 Jun, 2020
On 18 Nov, 2020
Received 22 Jul, 2020
On 17 Jul, 2020
Received 07 Jul, 2020
Received 02 Jul, 2020
Received 02 Jul, 2020
On 01 Jul, 2020
On 01 Jul, 2020
Invitations sent on 23 Jun, 2020
On 23 Jun, 2020
On 19 Jun, 2020
On 18 Jun, 2020
On 18 Jun, 2020
On 15 Jun, 2020
In this study, the self-extracted constipation treatment of traditional Chinese medicine extracts was applied to constipated rats. To explore the mechanism and role of the Chinese medicine for the treatment of constipation, the 16S rRNA sequencing and qRT-PCR technology were used to analyze the abundance and diversity of intestinal flora in rats. We found that the relative abundance of Firmicutes in the intestinal flora of rats with constipation was significantly higher than that in the control group, and the Bacteroides was significantly lower than that in the control group, while the relative abundance of Firmicutes was significantly changed after taking a certain dose of Chinese medicine, and reduced the relative abundance of Lachnospiraceae, and greatly increased the relative abundance of Lactobacillus, enhanced the symbiotic relationships of Lactobacillus with other intestinal flora. There was no significant difference in the total copies of intestinal bacteria between the constipated rats and the control group. The total copies of intestinal bacteria in the constipated rats decreased after taking the traditional Chinese medicine. Finally, this study results provides a theoretical basis for the treatment and understand the mechanism and effect of traditional Chinese medicine on rate constipation.
Figure 1
Figure 2
Figure 3
Figure 4