Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient’s Perspective

doi:10.21203/rs.3.rs-362903/v1

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Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient’s Perspective

https://doi.org/10.21203/rs.3.rs-362903/v1

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published 24 Jan, 2022

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Introduction:

Colon Capsule Endoscopy (CCE) has proven efficacy in a variety of gastrointestinal diseases. Few studies have assessed patient-reported outcomes and preference between colonoscopy and CCE.

Aims:

To identify comfort scores and patient preferences between CCE and colonoscopy.

Methods:

Patients from our centre who had both a CCE and colonoscopy within a 12-month period were identified. We performed over-the-phone interviews focused on satisfaction, comfort, and overall preference with a 10-point Likert scale. Electronic records were reviewed; reported Modified-Gloucester-Comfort-Scale (GCS) score, sedation, bowel preparation and endoscopist grade were documented. Data was compared between procedures. A Fishers exact test was used to compare proportions and a Student t-test was used to compare means, a p < 0.05 was considered significant.

Results:

In all, 40 patients were identified, 57.5% (23/40) were female and the mean age was 48 years (24 – 78). All patients were referred for investigation of lower gastrointestinal symptoms as part of an ongoing study (1).

There was a significance difference in mean comfort (9.2 vs 6.7, p<0.0001, 95% CI -3.51 to -1.44) but not satisfaction (8.3 vs 7.7, p=0.2, 95% CI -1.48 to 0.33) between CCE and colonoscopy. Main cause of dissatisfaction with CCE was bowel preparation and for colonoscopy was discomfort. Age and gender were not found to be variables. The correlation between GCS and patient reported values was weak (R = -0.28).

Overall, 77.5% (31/40) of patients would prefer a CCE if they required further bowel investigation. Of these, 77.4% (24/31) preferred a CCE despite the potential need for follow-up colonoscopy.

Conclusions:

CCE has a high satisfaction rating (8.3 vs 7.7) and has a higher patient reported comfort rating (9.2 vs 6.7) than colonoscopy. Studies have confirmed CCE and colonoscopy have equivalent diagnostic yields. The majority of patients in our cohort prefer CCE to colonoscopy. CCE should be considered as an alternative to colonoscopy in selected individuals.

Gastroenterology & Hepatology

Colon Capsule Endoscopy

Colonoscopy

Patient preference

Comfort

Lower gastrointestinal symptoms such as chronic diarrhoea and bleeding per rectum (PR) are a common cause for referral to the gastroenterology department. As symptoms alone are poor at predicting clinically significant disease, symptomatic patients are often referred for further investigations which may include a colonoscopy (2). Fibreoptic colonoscopy is a well-established modality for investigating the large bowel and offers both diagnostic and therapeutic potential for ileocolonic diseases.

Colonoscopies are performed in dedicated endoscopy units. In Ireland, they are usually performed under conscious sedation with Midazolam and Fentanyl. Even though colonoscopies are generally well tolerated and considered safe, they do come with potential risks. Levin et al reported that the incidence of adverse events from mostly diagnostic colonoscopies performed in an integrated healthcare system in the United States was 5 per 1000 procedures (95% CI, 4.0-6.2) (3). General complications associated with colonoscopies are usually related to sedation, bowel perforation and a risk of haemorrhage. A recent review article by the American Society of Gastrointestinal Endoscopy (ASGE) found a pooled perforation rate of 5.8 per 10,000 colonoscopies (95% CI, 5.7- 6.0), bleeding rate of 2.4 per 1000 colonoscopies (95% CI, 2.4-2.5), and death rate of 3 in 100,000 colonoscopies (4). Furthermore, there is a risk of causing pain and discomfort to the patient during colonoscopy. This is often associated with air insufflation, looping of the colonoscope, and traversing through bends in the colon. The risk of causing pain is often worse in younger, female patients with lower Body Mass Indices (BMI) or in patients who have had previous abdominal and pelvic surgery (5).

Apart from the risks of complications, there are also patient factors to be considered. Patients can be reluctant to undergo this invasive procedure due to their perceived embarrassment, inconvenience, or discomfort associated with colonoscopy (6, 7). In a study about anxiety related to colonoscopy in 1336 patients, Shafer et al found very high anxiety scores (>70) reported by 29% of patients relating to the procedure itself (8).

The European Society of Gastrointestinal Endoscopy (ESGE) has recommended Colon Capsule Endoscopy (CCE) as a safe alternative to colonoscopy in average risk individuals (9). CCE is considered less invasive and does not require air insufflation or sedation. Risks of CCE are minimum and has recently been reported in a meta-analysis by Wang et al as capsule retention (0.26%), swallowing difficulties (0.04%), technical failure (1.76%), incomplete colonic examination (19%), and discomfort (0.81%) (10). Wang et al did not find risks of capsule aspiration in any CCE studies (n=0/2671) but a pooled Video Capsule Endoscopy aspiration rate of 0% (n= 5/23,449) was reported (10).

CCE has proven efficacy to detect both neoplastic and non-neoplastic disease in selected patient cohorts including Inflammatory Bowel Disease patient assessment, average and low risk colorectal cancer screening, after incomplete colonoscopy and polyp surveillance (11-19). A recently published study from our centre also has shown that CCE had a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of 81%, 98%, 93% and 94% respectively in a symptomatic cohort when compared to colonoscopy (1). Despite its growing popularity and proven clinical efficacy, few studies have focused on patient preference between colonoscopy and CCE.

Aims:

The aim of this study was to identify patient reported outcomes of comfort and satisfaction in relation to both CCE and Colonoscopy and to establish if there was a difference in preference between both modalities. We also wanted to assess whether there was a difference in patient versus endoscopist reported comfort scores post colonoscopy.

This is a retrospective single centre comparative study conducted in Tallaght University Hospital (TUH), Ireland of patient reported satisfaction and comfort for CCE and colonoscopy procedures. TUH is an established CCE centre in Ireland, we perform about 250–300 CCEs per year.

We identified patients between the age of 18–80 from our electronic database who had both a CCE and colonoscopy over a 12-month period (Dec 2017 – Dec 2018). In order to prevent selection bias, all patients who had both tests over the period were contacted and invited to participate. All CCEs were performed using PillCam™ COLON 2 (Medtronic, Minneapolis, USA). Colonoscopy reports were generated and stored on a national endoscopy database, Unisoft (HD Clinical, Hertfordshire, UK).

Upon recruitment, we performed over-the-phone interviews a minimum of 3 months after completion of their investigations, focusing on questions related to satisfaction, comfort, and overall preference. Interviews were performed by trained medical professionals using secure hospital phone lines. Interview questions are listed in Table 1. A 10-point Likert scale was used to assess both comfort and satisfaction ranging from 1 (negative response) to 10 (positive response) for both CCE and colonoscopy procedures. The interviewers also asked each interviewee, if further colonic investigations were required, which test if either they would prefer; a CCE or colonoscopy. If patients had answered CCE as the preferred method of investigation, based on their own personal experience, the interviewer then asked if their answer would change if the CCE found findings that warranted referral on for a colonoscopy including incomplete CCE. The interviewer then asked an open-ended question regarding any cause of dissatisfaction for either CCE or colonoscopy.

In addition to the interview, we collected further demographic, clinical and procedural data for each patient from our CCE and endoscopy databases. Including bowel preparation and booster regimens, and capsule completion rate. Further colonoscopy data collected included; the Modified-Gloucester-Comfort-Scale (GCS) score, endoscopists grade and quality data (caecal intubation rate – CIR, polyp detection rate – PDR, and mean comfort score ≤ 3), amount of sedation used, whether air or Carbon Dioxide (CO2) insufflation was used and whether a scope guide was used during colonoscopy. The GCS is used at our centre and in all endoscopy units in Ireland. This score is usually given by the endoscopy nurses after the colonoscopy and agreed by the endoscopist in order to prevent an operator bias. As detailed in Table 2, a score of 1 refers to no discomfort while 5 is associated with severe discomfort. These scores are kept on a secure database and form part of the quality indicators for colonoscopy which is regularly audited as part of the National Quality Assurance Information System (NQAIS). This data is not available on endoscopy reports and is not routinely told to the patients post procedure. There was no endoscopist reported comfort score for CCE.

All obtained data were kept on secure encrypted hospital computers. Statistical analysis was performed using MedCalc (MedCalc Software Ltd, Belgium). A Chi-squared test was used to compare categorical data and a Student t-test was used to compare means, a p < 0.05 was deemed significant. Pearson Correlation Coefficient was used to assess the correlation between patient and operator reported comfort scores. A r value of ≥ 0.7 was considered as a strong correlation.

Study Population

In all, 40 patients were identified at our centre who had both a CCE and colonoscopy over the 12-months period. All the patients were contacted and were willing to participate in the over-the-phone interviews; 57.5% (23/40) of these were female, with a mean age of 48 (24-78) years. Both CCE and colonoscopy tests were performed as part of another prospective comparison study of CCE and colonoscopy for the investigation of symptoms in an average risk cohort (1). As such all participants were scheduled to have both procedures. All CCE tests, were performed before the colonoscopy. The interval between the two procedures was on average 6 weeks (range 2-8 weeks). The CCE report was available to the Endoscopist at the time of colonoscopy.

Bowel preparation

Bowel preparation for CCE was a split dose 4-liter (4L) Polyethylene glycol (PEG) (KleanPrep – Norgine, Middlesex, UK) with the addition of Phospho-soda, “Fleet” (Casen Recordati, Zaragoza, Spain), Gastrograffin (Bayer, Reading, UK) and rectal Bisacodyl (Dulcolax – Sanofi-Aventis, Ireland) suppository booster medications. Similarly, all patients received a further split dose 4L Polyethylene glycol (KleanPrep – Norgine, Middlesex, UK), bowel preparation prior to colonoscopy (Table 3). In addition, standard dietary manipulation was advised for several days prior to both procedures.

CCE data

CCE completion rate was 78% (n=31) with 100% (n=40) reaching the left colon. Positive findings were reported in 68% (n=27). Bowel preparation quality for CCE were reported as good/adequate in 36 (90%) and inadequate in 4 (10%).

Colonoscopy data

All colonoscopies were performed by two senior endoscopists who met NQAIS standards with CIR of 95.5%, 95.3%, PDR of 42.4%, 49.9% and mean GCS ≤ 3 of 99%, 96% respectively. All patients received procedural sedation with mean sedation of 4.2mg (range 2-8mg) of Midazolam and 68.1mcg (range 50mcg-100mcg) of Fentanyl. Caecal intubation was achieved in 92.5% (n=37). The scope guide was not used in any of the colonoscopy procedures. All colonoscopies were done under air insufflation only. Positive findings were reported in 65% (n=26). Bowel preparation quality for colonoscopy was reported as good/adequate in 36 (90%) and inadequate in 4 (10%). Total colonoscopy procedural times were not available.

There were no immediate or late procedural related complications for any patients for both their CCE and colonoscopy procedures. All patients were reviewed in clinic following their tests and appropriate follow up arranged.

Interview results

The mean interval between CCE to interview was 33 weeks (14 to 52 weeks) and the mean interval between colonoscopy to the interview was 30 weeks (12 to 50 weeks).

Regarding satisfaction score, mean satisfaction reported was 8.3 (range 3-10) for CCE and 7.7 (range 1-10) for colonoscopy. Regarding comfort score, mean comfort was 9.2 (range 6-10) for CCE vs 6.7 (1-10) for colonoscopy.

There was a statistically significant difference in mean comfort (9.2 vs 6.7, p<0.0001, 95% CI -3.51 to -1.44) but not satisfaction scores (8.3 vs 7.7, p=0.2, 95% CI -1.48 to 0.33) between CCE and colonoscopy respectively.

Of note the volume of bowel preparation and booster medications required was identified as the main cause of dissatisfaction with CCE (25%, n= 10/40). The main cause of dissatisfaction with colonoscopy was pain and discomfort (33%, n=13/40).

Subgroup analysis

Performing a subgroup analysis based on gender, mean satisfaction for males was 8 (range 3-10) for CCE and 8 (range 4-10) for colonoscopy; mean comfort was 9.2 (range 7-10) for CCE and 6.9 (range 1-10) respectively. Meanwhile for females, mean satisfaction was 8.4 (range 3-10) for CCE and 7.4 (range 1-10) for colonoscopy; mean comfort was 9.2 (range 6-10) for CCE and 6.6 (range 1-10) for colonoscopy respectively. There were statistically significant differences again reported for comfort scores for CCE versus colonoscopy for both genders [(9.2 vs 6.9, p=0.004, 95% CI -3.75 to -0.84) for males and (9.2 vs 6.6, p=0.002, 95% CI -4.16 to -1.06) for females] but not for satisfaction [(8 vs 8 ,p=1, 95% CI -1.06 to 1.06) for males and (8.4 vs 7.4, p=0.16, 95% CI -2.41 to 0.41) for females]. There was no significant difference between reported comfort and satisfaction comparing the two genders [satisfaction for CCE p= 0.56 (95% CI -1.02-1.69), satisfaction for colonoscopy p= 0.06 (95% CI -2.38-1.05), comfort for CCE p=0.8 (95% CI -0.72-0.8), comfort for colonoscopy p=0.73 (95% CI -2.11-1.56)].

When looking at age of patients above and below 50 (n=15 vs 25), mean satisfaction for <50 was 7.8 (range 3-10) for CCE and 7.9 (range 3-10) for colonoscopy; mean comfort for <50 was 9.4 (range 6-10) for CCE and 6.5 (range 1-10) for colonoscopy. Meanwhile for >50 mean satisfaction was 9 (range 4-10) for CCE and 7.3 (range 3-10) for colonoscopy; mean comfort for >50 was 8.9 (range 8-10) for CCE and 7.1 (range 2-10). There was no significant differences between comfort and satisfaction when comparing the two age groups [satisfaction for CCE 7.8 vs 9 p=0.3 (95%CI -0.31-2.53), satisfaction for colonoscopy 7.9 vs 7.2 p=0.2 (95%CI -2.4-1.1), comfort for CCE 9.3 vs 8.9 p=0.8 (95%CI -1.20.3), comfort for colonoscopy 6.5 vs 7.1 p=0.7 (95%CI -1.2-2.5)].

Patient preference

Overall, 77.5% (n=31/40) of patients would prefer CCE if they required a further lower GI investigation in the future. Of these, 77.4% (n=24/31) still preferred CCE despite the potential need for a follow-up colonoscopy. 70.6% (12/17) of males and 82.6% of females prefer CCE over colonoscopy and gender does not seem to affect this preference (p=0.37).

The mean reported Modified-Gloucester-Comfort-Scale for colonoscopies were 1.4 (range 1-4). When looking at the correlation between endoscopist reported GCS mean 1.4 (range 1-4) and patient reported scores 6.7 (1-10), only a weak negative correlation was found (r=-0.28). If we assume that comfort was defined as a GCS<3, and a 10-point scale score ≥7, 73% (n=29) of patients reported feeling comfortable with their colonoscopy while endoscopy reported comfort was 88% (n=35) with a weak positive correlation reported (r=0.44, p=0.004).

Our retrospective comparative study has found that CCE was reported by patients to be a more comfortable procedure (9.2 vs 6.7, p<0.0001) with comparable satisfaction scores compared to colonoscopy (8.3 vs 7.7, p=0.28). A majority of our patients (77.5%, n=31/40) also preferred to have a CCE compared to colonoscopy if a repeat endoscopic procedure is required in the future. Among these, a further 77.4% (24/31) of patients still preferred a CCE over colonoscopy even if the results of the CCE would require them to have a colonoscopy for any intervention or further diagnostic work-up.

The strength of this study is that to our knowledge, it is the only study that purely focuses on patient reported outcomes following both CCE and colonoscopy procedures in a symptomatic cohort. In a mix of screening and symptomatic patients, Ojidu et al reported in different group of patients undergoing either CCE, colonoscopy and CT colonoscopy (CTC) mean GCS’s of 1.3, 3.32, and 1.96 respectively (20). Furthermore, when comparing CCE and CTC, they also found that 76.8% reported no discomfort for CCE compared to 31.9% for CTC (20). In a CRC screening cohort, Thygesen et al reported moderate to high discomfort in 89% participants undergoing colonoscopy compared with7% undergoing CCE (21). It is interesting to note that despite receiving intravenous procedural sedation and analgesia for colonoscopy patient reported comfort scores are poorer, reflecting the invasive nature of this procedure.

We did not report on any patient diagnosis in this study and purely focused on patient reported procedural outcomes of comfort and satisfaction. The impact of diagnosis on the overall satisfaction and perceived comfort is not known. However, it should not significantly affect the results as patients were unselected and average risk and there were no cases of cancer detected.

An advantage is that all our participants were in a comparative study and underwent both tests giving subjects the opportunity to compare both procedures directly. This could however be considered not to reflect their preferences in actual clinical practice. In particular, the need for a therapeutic colonoscopy after a positive CCE could be a disadvantage. In our cohort though, the majority who reported a preference for CCE in the future, did so accepting of that possibility. In addition, this argument supposes there is never a need for a repeat colonoscopy, for preparation quality, anticoagulant or completion issues. As such the opportunity to directly compare tests remains a valid assessment.

Both procedures resulted in similar satisfaction scores (CCE - 8.3 vs colonoscopy - 7.7, p=0.28). For CCE, high satisfaction score could be related to the minimally invasive nature of the procedure, the fact that no/minimal discomfort or pain is involved, and the lack of embarrassment associated with colonoscopy. Furthermore, in our centre, CCEs are performed in our dedicated Capsule Endoscopy Department by trained nursing staff, medical staff, and technicians as outpatient procedures. As patients are not given any sedative medications for CCE, they can go about their day as normal, with some patients opting to return to work while others seek the comfort of their own homes. For colonoscopy, the high satisfaction score could be related to the professionalism of the endoscopy department staffs, the definitive nature of colonoscopy in most cases, and the ability to perform intervention on same procedure. The absence of complications in our cohort also could be associated with high satisfaction scores.

Of note for both procedures, patients are usually contacted prior to attending the procedure to ensure compliance with bowel preparation and diet, and to address any concerns that they may have, which could have contributed to similarly high overall satisfaction.

Despite having higher comfort and satisfaction scores, the amount of bowel preparation and booster medications (Table 3) that needed to be taken was identified as the main issue causing dissatisfaction with CCE (25% of patients). CCE relies on a high degree of bowel cleansing as it lacks the air insufflation and the ability to perform colonic cleaning and suctioning in colonoscopy. Apart from that, unlike for a Small Bowel Capsule (SBCE), booster medications are needed to propel the capsule through a patient’s small bowel and colon to ensure a complete examination. This regimen, although appearing excessive, is based on the 2012 ESGE guidelines for CCE (9). Since the completion of this study, CCE preparation in our unit has been changed to a lower volume split dose MoviPrep (Norgine, Middlesex, UK) preparation pre-CCE, with MoviPrep and Castor oil as boosters. Audits of these changes has shown an 87% capsule excretion rate and also improved image quality (22, 23). We have yet to assess patient’s satisfaction and comfort following this change but due to reduction of the volume of bowel preparation, one would assume higher scores will be awarded.

This study also highlights the disconnect between the level of comfort patients experienced compared to endoscopy reported Modified-Gloucester-Comfort-Scores. The GCS, although not formally validated, is used to assess patient comfort during colonoscopy in all Irish endoscopy units, forms part of quality indicators of colonoscopy and is regularly audited by NQAIS (24-26). Similar discordances have also been reported in other studies (20, 27). The GCS was designed to be provided by the endoscopy nurses and agreed by the endoscopist, but it is possible that they are too intimately involved in the procedure to provide a truly objective assessment (20). Poor comfort outcomes may cause patients to refrain from engaging with similar diagnostic tools in the future. Development and implementation of comfort scores that includes patient’s perspective such as the Patient-Reported Scale for Tolerability of Endoscopic Procedures (PRO-STEP) (28) or scores that have shown correlation with patient reported outcomes such as the St. Paul's endoscopy comfort score (SPECS) (24) should be considered. Although these scores are validated their use are not yet common. GCS itself has never been validated for patient use. To date, there isn’t a validated scoring system that measures both patients reported satisfaction and comfort. This is why we chose the simpler 10-point Likert scale in our interview for better patient comprehension and understanding.

In terms of factors that may be associated with comfort scores, Ball et al has reported that the amount of sedation given to a patient during colonoscopy does not correlate with comfort scores (ρ<0.2) (29). It has been previously reported that symptomatic patients often experience poorer comfort scores than screening patients (20), whether or not this played a role in our cohort is difficult to determine. The use of CO2 insufflation has been associated with better comfort scores (30), but we did not use CO2 in our colonoscopies during this study period due to unavailability. Since study completion, all endoscopy rooms in our department has been installed with a CO2 insufflation device. The correlation of its use and comfort score in our centre has yet to be reviewed. Both of our endoscopists performing the colonoscopies met and exceeded minimum NQAIS standards. The use of the scope guide has not been found to be beneficial in improving patients comfort scores in experienced endoscopists and is unlikely to have affected our results (31).

In our cohort, we did not find a difference between patients reported satisfaction and comfort when looking at age (less than and above 50) and gender as possible variables. We did not have available data to assess patients’ anxiety levels pre-procedure, duration of colonoscopy, patients BMI and endoscopist reported ease of colonoscopy, all of which may be possible factors that may result in a more difficult and uncomfortable procedure (5). This does open possibility for future prospective research.

As mentioned previously, 77.5% (31/40) of patients would prefer to have CCE over colonoscopy in the future. Interestingly of these 31 patients, 77.4% (24/31) would still choose to have CCE as first line even with the knowledge that they may have to have a colonoscopy as a second procedure if further investigation or intervention was required. As explained in the introduction, CCE has proven efficacy in a variety of clinical situations and can be used in both the symptomatic and screening cohort (11-19). As such, we would like to recommend Clinicians include alternatives to colonoscopy such as CCE when discussing available investigations with patients. Providing proven alternatives, especially ones that are associated with greater levels of comfort and less complications should form part of the process of informed consent.

CCE has a high satisfaction rating and has a higher comfort rating than colonoscopy in symptomatic patients. Studies have confirmed CCE and colonoscopy have equivalent diagnostic yields. The majority of patients in our cohort prefer CCE to colonoscopy. CCE should be considered as an alternative to colonoscopy in selected individuals.

This study has been approved as a service assessment by the quality improvement committee, Tallaght University Hospital.

All participants consented to participate and all parties consent to publication.

This study does not have any conflicting interest or any sources of funding.

Authors contribution: MS Ismail – co-first authors responsible for most writing, data collection, main idea for study. G Murphy – co-first author responsible for most patient interviews and data collection. S Semenov -data collection. D McNamara – senior clinician and researcher, providing ideas and insight, editing and proof-reading, assistance with statistical analysis and support.

Acknowledgments: Staff in Capsule Endoscopy Unit and Endoscopy Unit, Tallaght University Hospital. Dublin, Ireland.

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Table 1: Patient Questionnaire

Patient Questionnaire

On a scale of 1-10 (1=Negative / 10=Positive):

· How satisfied were you with your CCE?

· How satisfied were you with your colonoscopy?

· In terms of pain, how comfortable was your CCE?

· In terms of pain, how comfortable was your colonoscopy?

Preference:

· If you required further bowel testing in the future, would you rather a CCE or Colonoscopy?

Follow on Question (if above= “CCE”):

· Would your answer change if there was a likelihood/chance that you would require a colonoscopy following CCE (i.e. have both tests)?

Any particular reasons for your dissatisfaction with CCE and/or colonoscopy?

Table 2: Modified-Gloucester-Comfort-Scale

Score	Scale	Description
1	No	No discomfort, talking/resting comfortably throughout
2	Minimal	One or two episodes of mild discomfort (without distress)
3	Mild	More than two episodes of mild discomfort (without distress)
4	Moderate	Significant discomfort experienced several times with some distress
5	Severe	Extreme discomfort frequently during the test

Table 3: Bowel Preparation Regimen for CCE and Colonoscopy

Procedure

Bowel preparation

CCE

1 week before test

Stop all iron tablets

Day -2 (Day minus two, 2 days prior to study)

4 x 7.5mg Senna tablets at 7pm

Day -1 (Day minus one, 1 day prior to study)

Liquid diet throughout the day (includes black tea, black coffee, broth (no particles) etc

Drink at least 10 glasses of water

2 litres of KleanPrep (PEG) 7pm

Fast from midnight

Day 0 (test Day): 6am

9am

2 litres of KleanPrep (PEG)

CCE is swallowed

Small bowel reached

(normally takes approx. 20-30mins, patient is encouraged to walk around, if delayed in the stomach 10mg of IV Metoclopramide can be given, failing that options include endoscopic placement)

1^st booster of Sodium Phosphate (Fleet) 45mls (mix sachet with standard 150mls of water and extract 45mls)

+ 50mls of Gastrograffin mixed with 1 litre of water

Patient can leave the department. Instructions for 2^nd booster should be explained prior to departure

3 hours later

2nd bowel booster prepared by patient

2^nd booster of Sodium Phosphate (Fleet) 25mls (prepare as per booster 1)

+ 25mls of premeasured Gastrograffin and 500mls of water

Patient can eat and drink as normal at this point

2 hours post 2^nd booster

If capsule not passed, rectal bisacodyl suppository used

Colonoscopy

1 week before test

Stop all iron tablets

Day -1 (Day minus one, 1 day prior to study)

Liquid diet throughout the day (includes black tea, black coffee, broth (no particles) etc)

Drink at least 10 glasses of water

2 litres of KleanPrep (PEG) 7pm

Fast from midnight

Day 0 (test Day): 6am

2 litres of KleanPrep (PEG)

Table 4: Mean difference between CCE and Colonoscopy

	CCE	Colonoscopy	P value
Satisfaction	8.3	7.7	p=0.2, 95% CI -1.48 to 0.33
Male	8	8	p=1, 95% CI -1.06 to 1.06
Female	8.4	7.4	p=0.16, 95% CI -2.41 to 0.41
<50	7.8	7.9	p=0.8, 95%CI -0.83 to 1.07
>50	9	7.3	p=0.06, 95% CI -3.56 to 0.1

Comfort	9.2	6.7	p<0.0001, 95% CI -3.51 to -1.44
Male	9.2	6.9	p=0.004, 95% CI -3.75 to -0.84
Female	9.2	6.6	p=0.002, 95% CI -4.16 to -1.06
<50	9.4	6.5	P=0.0002, 95% CI -4.21 to -1.55
>50	8.9	7.1	p=0.05, 95% CI -3.62 to 0.02

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Journal Publication

published 24 Jan, 2022

Read the published version in BMC Gastroenterology →

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Submission checks completed at journal
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First submitted to journal
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Comparing Colon Capsule Endoscopy To Colonoscopy; A Symptomatic Patient’s Perspective

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