In order to investigate the damage range and distribution characteristics of rock blasting with empty holes under high in-situ stress, this study employs a theoretical analysis of the rock blasting mechanism and the impact of empty holes. Due to the impracticality of conducting in-situ stress model blasting tests in a laboratory, numerical simulation methods are commonly employed. In this paper, a high-energy explosive model and a rock RHT model are utilized to simulate the stress change process and the propagation of cracks under varying in-situ stress conditions. The primary objectives are to explore the influence of in-situ stress parameter selection on blasting outcomes and to analyze the processes of crack propagation and penetration. The numerical results demonstrate that the presence of empty holes amplifies the free plane effect, and the size of the holes remains consistent regardless of the spacing between them. Damage cracks within the rock mass exhibit a notable concentration in the horizontal direction, with crack development biased towards the direction of the hole. These findings confirm the guiding effect and stress concentration effect of the hole within the rock mass, facilitating the penetration of cracks between adjacent holes. Additionally, the discrepancy in length between horizontal and vertical damage cracks within the rock mass increases with higher horizontal and vertical stress differences. Under the same lateral stress coefficient, larger disparities in horizontal and vertical stress levels exert a more pronounced inhibitory effect on crack propagation. In the context of rock blasting in high in-situ stress conditions, the length of crack propagation between blast holes decreases as stress levels increase, with cracks predominantly extending in the direction of higher stress. As a result, strategically placing blast holes in alignment with the direction of greater stress and reducing hole spacing proves advantageous for enhancing crack penetration between blast holes and empty spaces. This research offers valuable insights into addressing the challenges of rock blasting during deep rock excavation processes.