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Research Article
Comparison of survival outcomes by different treatments for HIV-infected cervical cancer: a real-world study in a single center in China
Lan Zhang
Yunnan Cancer Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3084-6969
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Information on HIV-infected cervical cancer is very limited in China. The current study investigated long-term follow-up results of HIV-infected cervical cancer patients treated by different methods from an area in southwestern China in which HIV and cervical cancer are endemic.
Methods: All HIV-infected cervical cancer patients registered in Yunnan Cancer Hospital from January 2015 to December 2017 were retrospective reviewed. Overall survival (OS) was the primary end-point.
Results: A total of 47 patients entered into the study. 7 patients underwent radical surgery. 24 patients received radiotherapy with high palliative intent, including intensity modulated radiotherapy (IMRT)/volume modulated arc therapy (VMAT)/helical tomotherapy (TOMO) with simultaneous integrated boost (SIB) (SIB; n=15), IMRT/VMAT to the pelvis followed by late course boost (LCB) (LCB; n=9) to the gross tumor volume (GTV). 3 patients received simple external beam radiotherapy to the pelvis (EBRT) (SEBRT; n=3). 13 patients gave up anti-tumor therapy at the initial diagnosis.The 3-year OS for patients who received surgery, LCB, SIB, SEBRT, no anti-tumor treatment were 100%, 51.9%, 66.7%, 0%, and 0%. All of the deaths were attributed to cancer. The prognosis of HIV-infected cervical cancer patients was closely related to the treatment methods (p＜0.05).
Conclusions: LCB and SIB are effective and safe modality for treatment of HIV-infected cervical cancer in a limited resource setting.
Keywords
HIV, cervical cancer, treatment, SIB, LCB
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This is a preprint. It has not completed peer review.
Research Article
Comparison of survival outcomes by different treatments for HIV-infected cervical cancer: a real-world study in a single center in China
Lan Zhang
Yunnan Cancer Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3084-6969
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Information on HIV-infected cervical cancer is very limited in China. The current study investigated long-term follow-up results of HIV-infected cervical cancer patients treated by different methods from an area in southwestern China in which HIV and cervical cancer are endemic.
Methods: All HIV-infected cervical cancer patients registered in Yunnan Cancer Hospital from January 2015 to December 2017 were retrospective reviewed. Overall survival (OS) was the primary end-point.
Results: A total of 47 patients entered into the study. 7 patients underwent radical surgery. 24 patients received radiotherapy with high palliative intent, including intensity modulated radiotherapy (IMRT)/volume modulated arc therapy (VMAT)/helical tomotherapy (TOMO) with simultaneous integrated boost (SIB) (SIB; n=15), IMRT/VMAT to the pelvis followed by late course boost (LCB) (LCB; n=9) to the gross tumor volume (GTV). 3 patients received simple external beam radiotherapy to the pelvis (EBRT) (SEBRT; n=3). 13 patients gave up anti-tumor therapy at the initial diagnosis.The 3-year OS for patients who received surgery, LCB, SIB, SEBRT, no anti-tumor treatment were 100%, 51.9%, 66.7%, 0%, and 0%. All of the deaths were attributed to cancer. The prognosis of HIV-infected cervical cancer patients was closely related to the treatment methods (p＜0.05).
Conclusions: LCB and SIB are effective and safe modality for treatment of HIV-infected cervical cancer in a limited resource setting.
Figure 1
Figure 2
Figure 3
Figure 4