Ethical Approval and Consent to participate
Usage of the surveillance data of the patients with E196A and E196K gCJD in Chinese National CJD Surveillance System (CNS-CJD) has been approved by the Research Ethics Committee of National Institute for Viral Disease Control and Prevention, China CDC (CCDC).
Consent for publication
The written informed consent of each suspected case has been asked and signed by the family member or the relative of the patient according to the requirement of CJD surveillance. And all methods were carried out in accordance with relevant guidelines and regulations.
Availability of data and materials
All data generated or analysed during this study are included in this published article.
Competing interests
The authors declare that they have no competing interests
Funding
This work was supported by Chinese National Natural Science Foundation Grants (81630062), National Key R&D Program of China (2018ZX10711001, 2017YFC1200500), and Grant (2019SKLID501,2019SKLID603,2019SKLID307) from the State Key Laboratory for Infectious Disease Prevention and Control, China CDC.
Authors' contributions
Q.S. contributed to study design, performed assays and data analysis, and prepared the manuscript. K.X., W.Z.,C.G. and Y.Z.W. assisted with the assays of Western Blot analysis. L.P.G.,Y.W., C.H. and C.C. assisted with the animal tests. X.P.D. corresponding authors, contributed to design, study concept, and manuscript preparation.
Acknowledgements
We thanked the colleagues from CDC in all provinces and cities.
Authors' information
Corresponding Authors
Qi Shi - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University),
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; China Academy of Chinese Medical Sciences,
Beijing 100700, China; Email: [email protected]
Xiao-Ping Dong - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang
University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Global Public Health, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Center for Biosafety Mega-Science, Chinese
Academy of Sciences, Wuhan 430071, China; China Academy of Chinese Medical Sciences, Beijing 100700, China; orcid.org/0000-0002-1566-8447; Email: [email protected]
Author
Kang Xiao - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Cao Chen- State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Wei Zhou- State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Li-Ping Gao - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Yue-Zhang Wu - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Yuan Wang - State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang
University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Chao Hu- State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Chen Gao- State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (Zhejiang University), National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China