Background: Cardiac autonomic neuropathy (CAN) is one of the frequent complications of diabetes mellitus. Renin-angiotensin mechanism play role in the development of CAN which may be affected by exercise as well as yoga. Aim of the study was to study the effect of a 6-month supervised exercise program/ Yoga program on cardiac autonomic neuropathy (CAN) status and renin angiotensin (RAAS) parameters in a diagnosed case of CAN in Diabetes mellitus patients.
Method: Diagnosed patients with CAN in diabetes mellitus would be randomly divided into two groups. One group will undergo a supervised exercise program and the other would follow a supervised YOGA program. CAN parameters and RAS mechanism parameters would be assessed before and after the start of the exercise/Yoga program. CAN parameters and RAAS parameters would be assessed using a cardiac autonomic function test battery and measurement of Plasma renin, Serum aldosterone, Angiotensin II, ACE, and Angiotensin (1-7) respectively.
Discussion: The effect of exercise on cardiac autonomic function has been assessed, however, these studies are limited, the strength of evidence is low, and the need for RCT was stressed. How does exercise affect the RAS mechanism? There are limited studies in this area. Further various research has been recommended to study various components of the RAS mechanism. In India, work has been done mainly to assess the effect of the YOGA program on cardiac autonomic function in diabetes mellitus. There are no uniform findings. Further, literature regarding its effect on the RAS mechanism is limited. Internationally, work is focused on various exercise programs, while the focus was on the yoga program in India. There is a need to assess the effect of such a supervised program on the Indian population.
Trial registration: Registered with clinical trial registry of India and registration number is CTRI/2023/05/052268, registered retrospectively Keywords: Diabetes mellitus, cardiac autonomic neuropathy, angiotensin, rennin