See the published version of this preprint at BioMedical Engineering OnLine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Jingdong Xu
Capital Medical University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility. The aim of the study was to demonstrate that the imaging technique is an appropriate method for micron imaging of the gastric structures.
Methods: The stomachs of 4-, 6- and 12-week-old rats were removed and cleaned. XILPCI has 1000 times greater soft tissue contrast than that of X-ray traditional absorption radiography. The projection images of the rats’ stomachs were recorded by an XILPCI charge coupled device (CCD) at 9 μm image resolution.
Results: The X-ray in-line phase-contrast images of the different stages of rat gastric specimens clearly showed the gastric architectures and the details of the gastro-duodenal region. 3-dimensional stomach anatomical structure images were reconstruction.
Conclusion: The reconstructed gastric 3D images can clearly display the internal structure of the stomach. XILPCI may be a useful method for medical research in the future.
Keywords
Synchrotron radiation phase-contrast imaging, 3-dimensional gastric structure images, different stages
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BioMedical Engineering OnLine.
No community comments so far
Editorial decision: Major revision
On 21 Feb, 2021
Reviewer #1 agreed
On 20 Feb, 2021
Review #1 received
Received 20 Feb, 2021
Editor assigned
On 27 Nov, 2020
Reviewers invited
Invitations sent on 27 Nov, 2020
Submission checks complete
On 27 Nov, 2020
Editor invited
On 27 Nov, 2020
No comments provided
Editorial decision: Major revision
On 17 Nov, 2020
Reviewer #2 agreed
On 01 Nov, 2020
Review #2 received
Received 01 Nov, 2020
Reviewer #1 agreed
On 31 Oct, 2020
Review #1 received
Received 31 Oct, 2020
Reviewers invited
Invitations sent on 30 Oct, 2020
Editor assigned
On 29 Oct, 2020
Submission checks complete
On 29 Oct, 2020
Editor invited
On 29 Oct, 2020
Version 1
Posted 01 Jul, 2020
No comments provided
Editorial decision: Major revision
On 30 Sep, 2020
Review #1 received
Received 09 Aug, 2020
Review #2 received
Received 09 Aug, 2020
Reviewer #2 agreed
On 28 Jul, 2020
Reviewers invited
Invitations sent on 28 Jul, 2020
Reviewer #1 agreed
On 28 Jul, 2020
Editor assigned
On 30 Jun, 2020
First submitted
On 29 Jun, 2020
Submission checks complete
On 29 Jun, 2020
Editor invited
On 29 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Biomedical Engineering
Learn more about our company.
See the published version of this preprint at BioMedical Engineering OnLine.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Jingdong Xu
Capital Medical University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BioMedical Engineering OnLine.
No community comments so far
Editorial decision: Major revision
On 21 Feb, 2021
Reviewer #1 agreed
On 20 Feb, 2021
Review #1 received
Received 20 Feb, 2021
Editor assigned
On 27 Nov, 2020
Reviewers invited
Invitations sent on 27 Nov, 2020
Submission checks complete
On 27 Nov, 2020
Editor invited
On 27 Nov, 2020
No comments provided
Editorial decision: Major revision
On 17 Nov, 2020
Reviewer #2 agreed
On 01 Nov, 2020
Review #2 received
Received 01 Nov, 2020
Reviewer #1 agreed
On 31 Oct, 2020
Review #1 received
Received 31 Oct, 2020
Reviewers invited
Invitations sent on 30 Oct, 2020
Editor assigned
On 29 Oct, 2020
Submission checks complete
On 29 Oct, 2020
Editor invited
On 29 Oct, 2020
Version 1
Posted 01 Jul, 2020
No comments provided
Editorial decision: Major revision
On 30 Sep, 2020
Review #1 received
Received 09 Aug, 2020
Review #2 received
Received 09 Aug, 2020
Reviewer #2 agreed
On 28 Jul, 2020
Reviewers invited
Invitations sent on 28 Jul, 2020
Reviewer #1 agreed
On 28 Jul, 2020
Editor assigned
On 30 Jun, 2020
First submitted
On 29 Jun, 2020
Submission checks complete
On 29 Jun, 2020
Editor invited
On 29 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Biomedical Engineering
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BioMedical Engineering OnLine.
Background: The structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility. The aim of the study was to demonstrate that the imaging technique is an appropriate method for micron imaging of the gastric structures.
Methods: The stomachs of 4-, 6- and 12-week-old rats were removed and cleaned. XILPCI has 1000 times greater soft tissue contrast than that of X-ray traditional absorption radiography. The projection images of the rats’ stomachs were recorded by an XILPCI charge coupled device (CCD) at 9 μm image resolution.
Results: The X-ray in-line phase-contrast images of the different stages of rat gastric specimens clearly showed the gastric architectures and the details of the gastro-duodenal region. 3-dimensional stomach anatomical structure images were reconstruction.
Conclusion: The reconstructed gastric 3D images can clearly display the internal structure of the stomach. XILPCI may be a useful method for medical research in the future.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
This is a list of supplementary files associated with this preprint. Click to download.
Loading...