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Research article
Reflux Esophagitis and Fatigue: Are They Related?
Sung Hoon Jung
Catholic University of Korea
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9075-2027
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Gastroesophageal reflux disease (GERD) is a chronic, recurrent disease. Reflux esophagitis can interfere with sleep via acid reflux, which could cause daytime sleepiness or fatigue. However, little is known about the association between reflux esophagitis and fatigue
Objectives: We evaluated the association between fatigue and reflux esophagitis in subjects seen at health check-ups.
Methods: Consecutive patients who were scheduled for screening endoscopy were enrolled prospectively at the Comprehensive Medical Examination Center of St. Vincent Hospital and Eunpyeong St. Mary's Hospital, Korea. Three validated questionnaires were used to assess fatigue, daytime hypersomnolence, anxiety, and depression: the Multidimensional Fatigue Inventory-Korean version (MFI-K), Epworth Sleepiness Scale (ESS), and Hospital Anxiety and Depression Scale (HADS).
Results: We investigated 497 consecutive eligible subjects. The reflux esophagitis and symptomatic GERD groups comprised 103 (20.7%) and 92 (18.5%) subjects, respectively. The MFI-K total, ESS, HADS-anxiety, and HADS-depression scores did not differ between the esophagitis and non-esophagitis groups (50.0±11.5 vs. 49.7±10.9, P=0.661; 6.2±2.8 vs. 6.1±3.1, P=0.987; 5.8±3.1 vs. 5.2±3.2, P=0.060; 6.2±3.6 vs. 6.0±3.3, P=0.561). However, the MFI-K total, ESS, HADS-anxiety, and HADS-depression scores were higher in the symptomatic group than in the non-symptomatic group (54.7±12.7 vs. 48.6±10.3, P<0.001; 7.1±3.5 vs. 5.9±2.9, P=0.002; 6.4±3.3 vs. 5.1±3.1, P<0.001; 7.5±4.0 vs. 5.7±3.1, P<0.001). Multiple regression analysis showed that MFI-K total was correlated with GERD symptoms (P=0.021), women (P=0.001), anxiety (P<0.001) and depression (P<0.001).
Conclusion: There was no statistically significant association in which reflux esophagitis could cause daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, women, anxiety and depression. Further studies should clarify the association between fatigue and reflux esophagitis.
Keywords
Gastroesophageal reflux disease, Reflux esophagitis, esophagus, fatigue, depression
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Posted 03 Jan, 2021
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Reviewers invited
Invitations sent on 03 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Editor assigned
On 16 Dec, 2020
Submission checks complete
On 16 Dec, 2020
Editor invited
On 16 Dec, 2020
No comments provided
Editorial decision: Major revision
On 08 Dec, 2020
Review #1 received
Received 30 Nov, 2020
Reviewers invited
Invitations sent on 18 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Editor assigned
On 23 Oct, 2020
Submission checks complete
On 22 Oct, 2020
Editor invited
On 22 Oct, 2020
No comments provided
Editorial decision: Major revision
On 12 Oct, 2020
Review #2 received
Received 03 Oct, 2020
Reviewer #2 agreed
On 23 Sep, 2020
Review #1 received
Received 06 Aug, 2020
Reviewer #1 agreed
On 17 Jul, 2020
Reviewers invited
Invitations sent on 13 Jul, 2020
Submission checks complete
On 03 Jul, 2020
Editor invited
On 03 Jul, 2020
Editor assigned
On 01 Jul, 2020
First submitted
On 30 Jun, 2020
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Subject Areas
Gastroenterology & Hepatology
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This preprint is under consideration at BMC Gastroenterology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Reflux Esophagitis and Fatigue: Are They Related?
Sung Hoon Jung
Catholic University of Korea
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9075-2027
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 3
Posted 03 Jan, 2021
No community comments so far
Reviewers invited
Invitations sent on 03 Jan, 2021
Reviewer #1 agreed
On 03 Jan, 2021
Editor assigned
On 16 Dec, 2020
Submission checks complete
On 16 Dec, 2020
Editor invited
On 16 Dec, 2020
No comments provided
Editorial decision: Major revision
On 08 Dec, 2020
Review #1 received
Received 30 Nov, 2020
Reviewers invited
Invitations sent on 18 Nov, 2020
Reviewer #1 agreed
On 18 Nov, 2020
Editor assigned
On 23 Oct, 2020
Submission checks complete
On 22 Oct, 2020
Editor invited
On 22 Oct, 2020
No comments provided
Editorial decision: Major revision
On 12 Oct, 2020
Review #2 received
Received 03 Oct, 2020
Reviewer #2 agreed
On 23 Sep, 2020
Review #1 received
Received 06 Aug, 2020
Reviewer #1 agreed
On 17 Jul, 2020
Reviewers invited
Invitations sent on 13 Jul, 2020
Submission checks complete
On 03 Jul, 2020
Editor invited
On 03 Jul, 2020
Editor assigned
On 01 Jul, 2020
First submitted
On 30 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Gastroenterology & Hepatology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Gastroesophageal reflux disease (GERD) is a chronic, recurrent disease. Reflux esophagitis can interfere with sleep via acid reflux, which could cause daytime sleepiness or fatigue. However, little is known about the association between reflux esophagitis and fatigue
Objectives: We evaluated the association between fatigue and reflux esophagitis in subjects seen at health check-ups.
Methods: Consecutive patients who were scheduled for screening endoscopy were enrolled prospectively at the Comprehensive Medical Examination Center of St. Vincent Hospital and Eunpyeong St. Mary's Hospital, Korea. Three validated questionnaires were used to assess fatigue, daytime hypersomnolence, anxiety, and depression: the Multidimensional Fatigue Inventory-Korean version (MFI-K), Epworth Sleepiness Scale (ESS), and Hospital Anxiety and Depression Scale (HADS).
Results: We investigated 497 consecutive eligible subjects. The reflux esophagitis and symptomatic GERD groups comprised 103 (20.7%) and 92 (18.5%) subjects, respectively. The MFI-K total, ESS, HADS-anxiety, and HADS-depression scores did not differ between the esophagitis and non-esophagitis groups (50.0±11.5 vs. 49.7±10.9, P=0.661; 6.2±2.8 vs. 6.1±3.1, P=0.987; 5.8±3.1 vs. 5.2±3.2, P=0.060; 6.2±3.6 vs. 6.0±3.3, P=0.561). However, the MFI-K total, ESS, HADS-anxiety, and HADS-depression scores were higher in the symptomatic group than in the non-symptomatic group (54.7±12.7 vs. 48.6±10.3, P<0.001; 7.1±3.5 vs. 5.9±2.9, P=0.002; 6.4±3.3 vs. 5.1±3.1, P<0.001; 7.5±4.0 vs. 5.7±3.1, P<0.001). Multiple regression analysis showed that MFI-K total was correlated with GERD symptoms (P=0.021), women (P=0.001), anxiety (P<0.001) and depression (P<0.001).
Conclusion: There was no statistically significant association in which reflux esophagitis could cause daytime sleepiness, fatigue, anxiety, or depression. However, fatigue was associated with GERD symptoms, women, anxiety and depression. Further studies should clarify the association between fatigue and reflux esophagitis.