The stratospheric water vapor was found to increase during the period of last 30 years. This increase is helpful for the depletion as well as production of ozone in stratosphere. Moreover, some sources of nascent chlorine (Cl.) are still present in stratosphere because of their long-life span and over expected emission. The uses of such chemicals were strictly restricted from 1987, the year when Montreal Protocol was signed. Sometimes we found the Antarctic ozone hole area to cross the limit of the threshold value for these reasons. Artificial Neural Network has been applied in the current study. How much time the Antarctic ozone hole area was affected by such greenhouse gas (carbon di oxide, nitrous oxide, methane, CFC-11, water vapor and ozone itself) concentrations in atmosphere as input parameter is shown in the present paper.