CaTiO3-LnAlO3(Ln = La, Nd) ceramics were manufactured by reaction-sintering for produce low cost and high efficiency materials. Using reaction-sintering method to manufacture these ceramics, which have excellent comprehensive properties. The subtle variations on densification behavior, phase transformation, phase composition, microstructure evolution and performances of CaTiO3-LnAlO3(Ln = La, Nd) ceramics were studied systematically. The XRD pattern indicates that the Ca0.61La0.39Al0.39Ti0.61O3 phase and Ca0.7Nd0.3Ti0.7Al0.3O3 phase were generated under certain environmental conditions respectively. The ceramics exhibited excellent performance parameters: when εr is 42.03(45 635), the quality factor is 45500GHz (45 635) In addition, even in the environment of large temperature changes the ceramics can still maintain good performance. In conclusion, the reaction sintering method is an economic, convenient, available preparation means of making the CaTiO3-LnAlO3(Ln = La, Nd) ceramics and has broad prospects of application and development.