Ethics approval and consent to participate
All techniques used in this study were applied in accordance with the ethical standards of the Helsinki Declaration and the World Medical Association, with the approval of the University of Córdoba/IMIBIC and the research ethics committee of Córdoba (CETICO, Comité de Ética de la Investigación de Córdoba), and can be implemented within the HURS and the IMIBIC (protocol code PI19/01603, version 1, dated 13 March 2019). Written informed consent was obtained from each patient.
Consent for publication
Not applicable.
Availability of data and materials
The datasets used and analysed in this study are available upon reasonable request from the corresponding authors ([email protected] and [email protected]).
Competing interests
The authors declare no competing interests in relation to this study.
Funding
This work was supported by: i) Ref. PI22/01213 co-financed by the ISCIII Sub-directorate general for evaluation and research promotion (Subdirección General de Evaluación y Fomento de la Investigación) and the European Regional Development Fund (ERDF), ii) Ref. ProteoRed-0000141 (ISCIII) and iii) Ref. PRYES223170ARJO funded by “Asociación Española Contra el Cáncer – AECC” in the call “Ayudas a Proyectos Estratégicos 2022”.
Authors’ contributions:
ARR: Conception, data curation, formal analysis, funding acquisition, research, methodology, project administration, resources, supervision, visualisation, writing the original draft, and reviewing and editing the final draft.
MGR: Research, methodology, validation, visualisation, writing the original draft, and reviewing and editing the final draft.
FIB: Research, methodology, validation, visualisation, writing the original draft, and reviewing and editing the final draft.
FVM: Methodology, formal analysis, research, and reviewing and editing the final draft.
BRA: Methodology, formal analysis, validation, and reviewing and editing the final draft.
AML: Methodology, formal analysis, validation, and reviewing and editing the final draft.
LRO: Methodology, formal analysis, validation, resources, and reviewing and editing the final draft.
ROS: Formal analysis, validation, resources, and reviewing and editing the final draft.
MTM: Methodology, formal analysis, research, and reviewing and editing the final draft.
AMS: Methodology, formal analysis, research, and reviewing and editing the final draft.
JC: Formal analysis, methodology, writing the original draft, and reviewing and editing the final draft.
JAC: Formal analysis, validation, and reviewing and editing the final draft.
CMD: Formal analysis, methodology, writing the original draft, and reviewing and editing the final draft.
MCVB: Conception, data curation, formal analysis, funding acquisition, research, methodology, supervision, visualisation, writing the original draft, and reviewing and editing the final draft.
AAS: Conception, data curation, formal analysis, funding acquisition, research, methodology, project administration, resources, supervision, visualisation, writing the original draft, and reviewing and editing the final draft.
Acknowledgements:
We acknowledge Ángela Casado-Adam and Juan Manuel Sánchez-Hidalgo for their support during surgeries. Additionally, we acknowledge Luz Valero and Manuel M. Sanchez-del Pino from SCSIE Proteomics Facility at the University of Valencia (a member of Proteored, PRB3), and Eduardo Chicano-Gálvez and Ángela Peralbo-Molina from IMIBIC Mass Spectrometry and Molecular Imaging Unit (IMSMI) at the Maimonides Biomedical Research Institute of Cordoba (IMIBIC).