Shortened red blood cell age in patients with end-stage renal disease who were receiving haemodialysis: a cross-sectional study
Background: The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of anaemia in patients with end-stage renal disease who were undergoing maintenance dialysis by measuring erythrocyte creatine levels.
Methods: In a cross-sectional study, we evaluated 69 patients with end-stage renal disease who were receiving haemodialysis (n = 55) or peritoneal dialysis (n = 14). Erythrocyte creatine level, a quantitative marker of mean red blood cell (RBC) age, was measured.
Results: The mean RBC age was significantly shorter in the haemodialysis group than in the peritoneal dialysis group (47.7 days vs. 59.8 days, p<0.0001), although the haemoglobin levels were comparable between the groups. A Spearman correlation coefficient analysis revealed that shortened RBC age positively correlated with transferrin saturation (r = 0.54), ferritin level (r= 0.47), and haptoglobin level (r = 0.39) but inversely related with reticulocyte (r = −0.36), weekly doses of erythropoiesis-stimulating agents (ESAs; r = −0.62), erythropoietin resistance index (r = −0.64), and intradialytic ultrafiltration rate (r = −0.32).
Conclusions: Shortened RBC age was observed in patients who were receiving maintenance haemodialysis and was associated with iron deficiency, greater haptoglobin consumption, higher ESA requirements, and poor erythropoietin responsiveness, as well as with greater intradialytic fluid extraction.
Figure 1
Posted 31 Aug, 2020
On 26 Aug, 2020
On 25 Aug, 2020
On 25 Aug, 2020
On 20 Aug, 2020
On 18 Aug, 2020
On 17 Aug, 2020
On 17 Aug, 2020
Received 18 Jul, 2020
On 18 Jul, 2020
On 18 Jul, 2020
Received 16 Jul, 2020
Invitations sent on 13 Jul, 2020
On 13 Jul, 2020
On 02 Jul, 2020
On 01 Jul, 2020
On 01 Jul, 2020
On 30 Jun, 2020
Shortened red blood cell age in patients with end-stage renal disease who were receiving haemodialysis: a cross-sectional study
Posted 31 Aug, 2020
On 26 Aug, 2020
On 25 Aug, 2020
On 25 Aug, 2020
On 20 Aug, 2020
On 18 Aug, 2020
On 17 Aug, 2020
On 17 Aug, 2020
Received 18 Jul, 2020
On 18 Jul, 2020
On 18 Jul, 2020
Received 16 Jul, 2020
Invitations sent on 13 Jul, 2020
On 13 Jul, 2020
On 02 Jul, 2020
On 01 Jul, 2020
On 01 Jul, 2020
On 30 Jun, 2020
Background: The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of anaemia in patients with end-stage renal disease who were undergoing maintenance dialysis by measuring erythrocyte creatine levels.
Methods: In a cross-sectional study, we evaluated 69 patients with end-stage renal disease who were receiving haemodialysis (n = 55) or peritoneal dialysis (n = 14). Erythrocyte creatine level, a quantitative marker of mean red blood cell (RBC) age, was measured.
Results: The mean RBC age was significantly shorter in the haemodialysis group than in the peritoneal dialysis group (47.7 days vs. 59.8 days, p<0.0001), although the haemoglobin levels were comparable between the groups. A Spearman correlation coefficient analysis revealed that shortened RBC age positively correlated with transferrin saturation (r = 0.54), ferritin level (r= 0.47), and haptoglobin level (r = 0.39) but inversely related with reticulocyte (r = −0.36), weekly doses of erythropoiesis-stimulating agents (ESAs; r = −0.62), erythropoietin resistance index (r = −0.64), and intradialytic ultrafiltration rate (r = −0.32).
Conclusions: Shortened RBC age was observed in patients who were receiving maintenance haemodialysis and was associated with iron deficiency, greater haptoglobin consumption, higher ESA requirements, and poor erythropoietin responsiveness, as well as with greater intradialytic fluid extraction.
Figure 1