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Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma
Xiaomei Lao
Sun Yat-Sen University Guanghua School of Stomatology
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5767-1823
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cancer.
Background: The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC.
Methods: We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed.
Results: Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC ( P =0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR=2.1, P =0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery ( P =0.005, 0.001 and 0.244, respectively).
Conclusion: In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T 1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.
Keywords
D-dimer, fibrinogen, platelets, oral squamous cell carcinoma, prognosis
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Reviewer #2 agreed
On 27 Dec, 2020
Reviewer #1 agreed
On 23 Dec, 2020
Reviewers invited
Invitations sent on 21 Dec, 2020
Editor assigned
On 20 Dec, 2020
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On 20 Dec, 2020
Editor invited
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Editorial decision: Major revision
On 13 Dec, 2020
Editor assigned
On 06 Dec, 2020
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On 06 Dec, 2020
Editor invited
On 06 Dec, 2020
Version (no preprint)
Posted 05 Nov, 2020
Editorial decision: Major revision
On 05 Nov, 2020
Review #2 received
Received 03 Nov, 2020
Review #1 received
Received 03 Nov, 2020
Editor assigned
On 15 Oct, 2020
Reviewers invited
Invitations sent on 15 Oct, 2020
Reviewer #1 agreed
On 15 Oct, 2020
Reviewer #2 agreed
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 29 Aug, 2020
Review #3 received
Received 28 Aug, 2020
Reviewer #3 agreed
On 04 Aug, 2020
Review #2 received
Received 30 Jul, 2020
Review #1 received
Received 28 Jul, 2020
Reviewer #2 agreed
On 11 Jul, 2020
Reviewer #1 agreed
On 08 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Editor assigned
On 06 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
First submitted
On 30 Jun, 2020
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This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma
Xiaomei Lao
Sun Yat-Sen University Guanghua School of Stomatology
Corresponding Author
ORCiD: https://orcid.org/0000-0001-5767-1823
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 3
Posted 21 Jan, 2021
Published
On 05 Feb, 2021
No community comments so far
Review #1 received
Received 12 Jan, 2021
Reviewer #2 agreed
On 27 Dec, 2020
Reviewer #1 agreed
On 23 Dec, 2020
Reviewers invited
Invitations sent on 21 Dec, 2020
Editor assigned
On 20 Dec, 2020
Submission checks complete
On 20 Dec, 2020
Editor invited
On 20 Dec, 2020
No comments provided
Editorial decision: Major revision
On 13 Dec, 2020
Editor assigned
On 06 Dec, 2020
Submission checks complete
On 06 Dec, 2020
Editor invited
On 06 Dec, 2020
Version (no preprint)
Posted 05 Nov, 2020
Editorial decision: Major revision
On 05 Nov, 2020
Review #2 received
Received 03 Nov, 2020
Review #1 received
Received 03 Nov, 2020
Editor assigned
On 15 Oct, 2020
Reviewers invited
Invitations sent on 15 Oct, 2020
Reviewer #1 agreed
On 15 Oct, 2020
Reviewer #2 agreed
On 15 Oct, 2020
Submission checks complete
On 14 Oct, 2020
Editor invited
On 14 Oct, 2020
This version was not preprinted
No comments provided
Editorial decision: Major revision
On 29 Aug, 2020
Review #3 received
Received 28 Aug, 2020
Reviewer #3 agreed
On 04 Aug, 2020
Review #2 received
Received 30 Jul, 2020
Review #1 received
Received 28 Jul, 2020
Reviewer #2 agreed
On 11 Jul, 2020
Reviewer #1 agreed
On 08 Jul, 2020
Reviewers invited
Invitations sent on 07 Jul, 2020
Editor assigned
On 06 Jul, 2020
Submission checks complete
On 02 Jul, 2020
Editor invited
On 02 Jul, 2020
First submitted
On 30 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cancer.
Background: The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC.
Methods: We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed.
Results: Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC ( P =0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR=2.1, P =0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery ( P =0.005, 0.001 and 0.244, respectively).
Conclusion: In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T 1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.
Figure 1
Figure 2