Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma
Background: The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC.
Methods: We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed.
Results: Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC ( P =0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR=2.1, P =0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery ( P =0.005, 0.001 and 0.244, respectively).
Conclusion: In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T 1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.
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Posted 21 Jan, 2021
On 05 Feb, 2021
Received 12 Jan, 2021
On 27 Dec, 2020
On 23 Dec, 2020
Invitations sent on 21 Dec, 2020
On 20 Dec, 2020
On 20 Dec, 2020
On 20 Dec, 2020
On 13 Dec, 2020
On 06 Dec, 2020
On 06 Dec, 2020
On 06 Dec, 2020
Posted 05 Nov, 2020
On 05 Nov, 2020
Received 03 Nov, 2020
Received 03 Nov, 2020
On 15 Oct, 2020
Invitations sent on 15 Oct, 2020
On 15 Oct, 2020
On 15 Oct, 2020
On 14 Oct, 2020
On 14 Oct, 2020
On 29 Aug, 2020
Received 28 Aug, 2020
On 04 Aug, 2020
Received 30 Jul, 2020
Received 28 Jul, 2020
On 11 Jul, 2020
On 08 Jul, 2020
Invitations sent on 07 Jul, 2020
On 06 Jul, 2020
On 02 Jul, 2020
On 02 Jul, 2020
On 30 Jun, 2020
Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma
Posted 21 Jan, 2021
On 05 Feb, 2021
Received 12 Jan, 2021
On 27 Dec, 2020
On 23 Dec, 2020
Invitations sent on 21 Dec, 2020
On 20 Dec, 2020
On 20 Dec, 2020
On 20 Dec, 2020
On 13 Dec, 2020
On 06 Dec, 2020
On 06 Dec, 2020
On 06 Dec, 2020
Posted 05 Nov, 2020
On 05 Nov, 2020
Received 03 Nov, 2020
Received 03 Nov, 2020
On 15 Oct, 2020
Invitations sent on 15 Oct, 2020
On 15 Oct, 2020
On 15 Oct, 2020
On 14 Oct, 2020
On 14 Oct, 2020
On 29 Aug, 2020
Received 28 Aug, 2020
On 04 Aug, 2020
Received 30 Jul, 2020
Received 28 Jul, 2020
On 11 Jul, 2020
On 08 Jul, 2020
Invitations sent on 07 Jul, 2020
On 06 Jul, 2020
On 02 Jul, 2020
On 02 Jul, 2020
On 30 Jun, 2020
Background: The relationship between cancer and coagulation has been intensively studied in recent years; however, the effects of coagulation factors on oral squamous cell carcinoma (OSCC) have rarely been reported. This study aimed to investigate the relationship between preoperative D-dimer (DD), fibrinogen (FIB), platelets (PLT) and OSCC, as well as the prognostic value of DD, FIB and PLT in OSCC.
Methods: We retrospectively investigated a total of 202 patients with OSCC treated at Guanghua Hospital of Stomatology, Sun Yat-sen University. Baseline demographic and clinicopathological information as well as both preoperative and postoperative DD, FIB and PLT results were collected from each patient, and patients with primary OSCC were followed up for disease progression, death or the end of the study. The correlations between preoperative DD, FIB, PLT and other clinical features, as well as the therapeutic effect and PFS were analysed statistically, and postoperative DD and surgical parameters were also analysed.
Results: Preoperative DD was significantly correlated with T stage, N stage, clinical stage and relapse of OSCC ( P =0.000, 0.001, 0.000 and 0.000, respectively). Univariate Cox regression analyses showed that high preoperative DD predicted poor prognosis in patients with OSCC (HR=2.1, P =0.033), while FIB and PLT showed no prognostic values. Postoperative DD was significantly correlated with preoperative DD and surgical type but not the duration of surgery ( P =0.005, 0.001 and 0.244, respectively).
Conclusion: In this study, we suggested that high preoperative DD level may serve as an indicator for synchronous neck dissection in patients with T 1, 2 OSCC, and the elevated DD level might be the marker of disease progression in patient follow up.
Figure 1
Figure 2