[1] Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL et al: The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. ANN RHEUM DIS 2014, 73(7):1323-1330.
[2] Kim JR, Yoo JJ, Kim HA: Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis. INT J MOL SCI 2018, 19(3).
[3] Tang X, Wang S, Zhan S, Niu J, Tao K, Zhang Y, Lin J: The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study. ARTHRITIS RHEUMATOL 2016, 68(3):648-653.
[4] Latourte A, Kloppenburg M, Richette P: Emerging pharmaceutical therapies for osteoarthritis. NAT REV RHEUMATOL 2020, 16(12):673-688.
[5] UK NCGC: Osteoarthritis: Care and Management in Adults. London: National Institute for Health and Care Excellence (UK); 2014.
[6] Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H, Carr AJ: Osteoarthritis. LANCET 2015, 386(9991):376-387.
[7] Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P: American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 2012, 64(4):465-474.
[8] Yang M, Jiang L, Wang Q, Chen H, Xu G: Traditional Chinese medicine for knee osteoarthritis: An overview of systematic review. PLOS ONE 2017, 12(12):e189884.
[9] Wang L, Zhang XF, Zhang X, Guo DY, Duan YW, Wang ZC, Pei LS, Ru H, Cheng JX, Shi YJ et al: Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis. PAIN RES MANAG 2020, 2020:5712187.
[10] The State Pharmacopoeia Committee of People’s Republic of China. Pharmacopoeia of People’s Republic of China. Vol. 1. In., vol. pp. 40–41, 58,127,193,233,247–248.: Chemical Industry Press; Beijing, China: 2020.
[11] Zhou Y, Cui Y, Liu Y, Shen G: [Bioavailability study on xiaohuoluo pills]. Zhongguo Zhong Yao Za Zhi 1995, 20(3):159-161, 191.
[12] Pan J XLZD: Immunosuppresive, antioxidative, anti-inflammatory and analgesic effect of Xiahuoluo pills. Chinese Journal of Clinical Rehabilitation 2006(2006(47):183-188.).
[13] Cui P, Han H, Wang R, Yang L: Identification and determination of Aconitum alkaloids in Aconitum herbs and Xiaohuoluo pill using UPLC-ESI-MS. MOLECULES 2012, 17(9):10242-10257.
[14] Kiss T, Orvos P, Bánsághi S, Forgo P, Jedlinszki N, Tálosi L, Hohmann J, Csupor D: Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. FITOTERAPIA 2013, 90:85-93.
[15] Seo M, Lee JH, Baek M, Kim MA, Ahn MY, Kim SH, Yun EY, Hwang JS: A novel role for earthworm peptide Lumbricusin as a regulator of neuroinflammation. Biochem Biophys Res Commun 2017, 490(3):1004-1010.
[16] Li C, Chen M, Li X, Yang M, Wang Y, Yang X: Purification and function of two analgesic and anti-inflammatory peptides from coelomic fluid of the earthworm, Eisenia foetida. PEPTIDES 2017, 89:71-81.
[17] Ge CY, Zhang JL: Bioactive sesquiterpenoids and steroids from the resinous exudates of Commiphora myrrha. NAT PROD RES 2019, 33(3):309-315.
[18] Liang Y LPHQ: Acetyl-11-keto-beta-boswellic acid regulates the activities of matrix metalloproteinases-1,-2,-9. Chinese Journal of Pathophysiolog 2009(2009, 25(10):2004-2011.).
[19] Ammon HP: Modulation of the immune system by Boswellia serrata extracts and boswellic acids. PHYTOMEDICINE 2010, 17(11):862-867.
[20] Li S, Zhang B: Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med 2013, 11(2):110-120.
[21] Lee WY, Lee CY, Kim YS, Kim CE: The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology. Biomolecules 2019, 9(8).
[22] Santolini M, Barabási AL: Predicting perturbation patterns from the topology of biological networks. Proc Natl Acad Sci U S A 2018, 115(27):E6375-E6383.
[23] Chen S, Kang J, Xing Y, Zhao Y, Milton DK: Estimating large covariance matrix with network topology for high-dimensional biomedical data. Computational Statistics and Data Analysis 2018, 127.
[24] Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y et al: TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 2014, 6:13.
[25] Wan Y, Xu L, Liu Z, Yang M, Jiang X, Zhang Q, Huang J: Utilising network pharmacology to explore the underlying mechanism of Wumei Pill in treating pancreatic neoplasms. BMC Complement Altern Med 2019, 19(1):158.
[26] Xu X, Zhang W, Huang C, Li Y, Yu H, Wang Y, Duan J, Ling Y: A novel chemometric method for the prediction of human oral bioavailability. INT J MOL SCI 2012, 13(6):6964-6982.
[27] Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T: Cytoscape: a software environment for integrated models of biomolecular interaction networks. GENOME RES 2003, 13(11):2498-2504.
[28] Assenov Y, Ramírez F, Schelhorn SE, Lengauer T, Albrecht M: Computing topological parameters of biological networks. BIOINFORMATICS 2008, 24(2):282-284.
[29] Metsalu T, Vilo J: ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap. NUCLEIC ACIDS RES 2015, 43(W1):W566-W570.
[30] Heberle H, Meirelles GV, Da SF, Telles GP, Minghim R: InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams. BMC BIOINFORMATICS 2015, 16(1):169.
[31] Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P et al: STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. NUCLEIC ACIDS RES 2019, 47(D1):D607-D613.
[32] Martin A, Ochagavia ME, Rabasa LC, Miranda J, Fernandez-de-Cossio J, Bringas R: BisoGenet: a new tool for gene network building, visualization and analysis. BMC BIOINFORMATICS 2010, 11:91.
[33] Yu G, Wang LG, Han Y, He QY: clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 2012, 16(5):284-287.
[34] Trott O, Olson AJ: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J COMPUT CHEM 2010, 31(2):455-461.
[35] Nguyen NT, Nguyen TH, Pham T, Huy NT, Bay MV, Pham MQ, Nam PC, Vu VV, Ngo ST: Autodock Vina Adopts More Accurate Binding Poses but Autodock4 Forms Better Binding Affinity. J CHEM INF MODEL 2020, 60(1):204-211.
[36] Cao H, Sun Y, Wang L, Zhao C, Fu J, Zhang A: Understanding the microscopic binding mechanism of hydroxylated and sulfated polybrominated diphenyl ethers with transthyretin by molecular docking, molecular dynamics simulations and binding free energy calculations. MOL BIOSYST 2017, 13(4):736-749.
[37] Zhang L, Shi X, Huang Z, Mao J, Mei W, Ding L, Zhang L, Xing R, Wang P: Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Radix Achyranthis Bidentatae on Osteoarthritis. BMC Complement Med Ther 2020, 20(1):121.
[38] Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y: Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology. Evid Based Complement Alternat Med 2018, 2018:6503126.
[39] Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD: Molecular properties that influence the oral bioavailability of drug candidates. J MED CHEM 2002, 45(12):2615-2623.
[40] Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY: cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC SYST BIOL 2014, 8 Suppl 4(Suppl 4):S11.
[41] Huang C, Zheng C, Li Y, Wang Y, Lu A, Yang L: Systems pharmacology in drug discovery and therapeutic insight for herbal medicines. BRIEF BIOINFORM 2014, 15(5):710-733.
[42] Hu Y, Gui Z, Zhou Y, Xia L, Lin K, Xu Y: Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages. Free Radic Biol Med 2019, 145:146-160.
[43] Gabay O, Sanchez C, Salvat C, Chevy F, Breton M, Nourissat G, Wolf C, Jacques C, Berenbaum F: Stigmasterol: a phytosterol with potential anti-osteoarthritic properties. Osteoarthritis Cartilage 2010, 18(1):106-116.
[44] Kim KA, Lee IA, Gu W, Hyam SR, Kim DH: β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway. MOL NUTR FOOD RES 2014, 58(5):963-972.
[45] Lin Z, Lin C, Fu C, Lu H, Jin H, Chen Q, Pan J: The protective effect of Ellagic acid (EA) in osteoarthritis: An in vitro and in vivo study. BIOMED PHARMACOTHER 2020, 125:109845.
[46] Zupan J, Vrtačnik P, Cör A, Haring G, Weryha G, Visvikis-Siest S, Marc J: VEGF-A is associated with early degenerative changes in cartilage and subchondral bone. GROWTH FACTORS 2018, 36(5-6):263-273.
[47] Hamilton JL, Nagao M, Levine BR, Chen D, Olsen BR, Im HJ: Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain. J BONE MINER RES 2016, 31(5):911-924.
[48] Vadalà G, Russo F, Musumeci M, Giacalone A, Papalia R, Denaro V: Targeting VEGF-A in cartilage repair and regeneration: state of the art and perspectives. J Biol Regul Homeost Agents 2018, 32(6 Suppl. 1):217-224.
[49] Zan PF, Yao J, Wu Z, Yang Y, Hu S, Li GD: Cyclin D1 Gene Silencing Promotes IL-1β-Induced Apoptosis in Rat Chondrocytes. J CELL BIOCHEM 2018, 119(1):290-299.
[50] Zou J, Li XL, Shi ZM, Xue JF: Effects of C-myc gene silencing on interleukin-1β-induced rat chondrocyte cell proliferation, apoptosis and cytokine expression. J BONE MINER METAB 2018, 36(3):286-296.
[51] Rhee J, Park SH, Kim SK, Kim JH, Ha CW, Chun CH, Chun JS: Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction. ANN RHEUM DIS 2017, 76(2):427-434.
[52] Teng P, Liu Y, Dai Y, Zhang H, Liu WT, Hu J: Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the α7 Nicotinic Acetylcholine Receptor. J IMMUNOL 2019, 203(2):485-492.
[53] Jackson MT, Moradi B, Smith MM, Jackson CJ, Little CB: Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes. ARTHRITIS RHEUMATOL 2014, 66(6):1525-1536.
[54] Xue M, McKelvey K, Shen K, Minhas N, March L, Park SY, Jackson CJ: Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford) 2014, 53(12):2270-2279.
[55] Eskelinen A, Tanska P, Florea C, Orozco GA, Julkunen P, Grodzinsky AJ, Korhonen RK: Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus. PLOS COMPUT BIOL 2020, 16(6):e1007998.
[56] Zevenbergen L, Gsell W, Chan DD, Vander SJ, Himmelreich U, Neu CP, Jonkers I: Functional assessment of strains around a full-thickness and critical sized articular cartilage defect under compressive loading using MRI. Osteoarthritis Cartilage 2018, 26(12):1710-1721.
[57] Myller K, Korhonen RK, Töyräs J, Salo J, Jurvelin JS, Venäläinen MS: Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo. J ORTHOP RES 2019, 37(5):1042-1051.
[58] Wang T, He C: Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev 2018, 44:38-50.
[59] Liao CR, Wang SN, Zhu SY, Wang YQ, Li ZZ, Liu ZY, Jiang WS, Chen JT, Wu Q: Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression. REDOX BIOL 2020, 28:101306.
[60] Sun K, Luo J, Guo J, Yao X, Jing X, Guo F: The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review. Osteoarthritis Cartilage 2020, 28(4):400-409.
[61] Ke H, Mou X, Xia Q: Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation. Ann Transl Med 2020, 8(22):1487.