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Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds
Jennifer Weidhaas
University of Utah
Corresponding Author
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease (COVID-19), is shed in feces and the virus RNA is detectable in wastewater. A nine-week wastewater epidemiology study of ten wastewater facilities, serving 39% of the state of Utah or 1.26M individuals was conducted in April and May of 2020. COVID-19 cases were tabulated from within each sewershed boundary by public health partners. The virus was detectable in 61% of 126 unique wastewater samples. Urban sewersheds serving >100,000 individuals and tourist communities had higher detection frequencies of the virus RNA. An outbreak of COVID-19 across two communities correlated with an increase in SARS-CoV-2 RNA in wastewater, while a decline in COVID-19 case counts preceded a decline in SARS-CoV-2 RNA. These results demonstrate the utility of wastewater epidemiology to assist in public health responses to COVID-19.
Keywords
SARS-CoV-2, COVID-19, wastewater epidemiology, disease burden, sewershed, interceptor
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This preprint is under consideration at a Nature Research journal. Preprints are preliminary reports that have not undergone peer review. They should not be considered conclusive, used to inform clinical practice, or referenced by the media as validated information.
Nature journals have partnered with Research Square to offer In Review, a journal-integrated preprint deposition service.
Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds
Jennifer Weidhaas
University of Utah
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 15 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease (COVID-19), is shed in feces and the virus RNA is detectable in wastewater. A nine-week wastewater epidemiology study of ten wastewater facilities, serving 39% of the state of Utah or 1.26M individuals was conducted in April and May of 2020. COVID-19 cases were tabulated from within each sewershed boundary by public health partners. The virus was detectable in 61% of 126 unique wastewater samples. Urban sewersheds serving >100,000 individuals and tourist communities had higher detection frequencies of the virus RNA. An outbreak of COVID-19 across two communities correlated with an increase in SARS-CoV-2 RNA in wastewater, while a decline in COVID-19 case counts preceded a decline in SARS-CoV-2 RNA. These results demonstrate the utility of wastewater epidemiology to assist in public health responses to COVID-19.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Due to technical limitations, full-text HTML conversion of this manuscript could not be completed. However, the manuscript can be downloaded and accessed as a PDF.