Patient characteristics
Finally, a total of 2288 meropenem-treated patients qualified for analysis. Among them, 1,234 cases were in the generic group and 1,054 cases were in the brand-name group. After PSM, 600 patients were successfully matched (generic: brand-name = 1:1), with a success rate of 52.4%. All variables were checked and matched well (p > 0.05) (Figure 1). Before PSM, admission, underlying diseases and types of Infection were statistically different between the generic and brand-name groups. After 1:1 PSM, no significant differences were apparent between two groups (Table 1). Among 600 propensity score–matched patients (mean age, 65 years; gender [proportion of males, 60.5% vs. 61.0%, p = 0.859], admission [emergency, 50.2% vs. 54.3%, p = 0.149], underlying disease [positive, 58.2% vs. 58.7%, p = 0.861], combined fungal infection [positive, 45.3% vs. 41.0%, p = 0.145], dose [<3 g/d, 34.8% vs. 34.8%, p = 0.923], number of other antimicrobial agents [0, 47.8% vs. 49.2%, 1, 30.0% vs. 31.5%, ≥2, 22.2% vs. 19.3%, p = 0.475]).
Table 1. Baseline Characteristics between generic group and brand-name group.
![](data:image/png;base64,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)
Abbreviations: IQR, interquartile range.
Efficacy
The effective rate was 74.5% in the generic group and 77.0% in the brand-name group. No statistical differences exist between the two groups (Table 2). 13.8% for the generic group and 20.0% for the brand-name group, respectively. The results of the bacterial clearance rate showed notable variations between the two groups, with the brand-name group exhibiting a greater bacterial clearance rate than the generic group (Table 3). A stratified analysis was performed on the type of infection strains (Table 4). There is a statistically significant difference in the clearance rates of Escherichia coli between generic and brand-name groups (P=0.002).
The results of the infection-related laboratory test markers are displayed in Table 5. The degree of inflammatory factor reduction achieved by generic and brand-name meropenem was equivalent. The differences between the generic and brand-name groups' pre- and post-treatment CRP, PCT, WBC, and NEUT% levels were statistically significant (P<0.001). Additionally, following treatment, inflammatory factor levels were significantly lower than pre-treatment levels, suggesting that the generic and brand-name groups might help lower inflammatory factor levels by preventing infections. The degree of CRP, PCT, WBC, and NEUT% reduction between the generic and brand-name groups did not differ significantly.
Table 2. Comparison of clinical outcomes between generic group and brand-name group.
Variables, n (%)
|
Generic
(n=600)
|
Brand-name
(n=600)
|
P
|
Recovery
|
2
|
0
|
|
improvement
|
445
|
462
|
|
ineffectiveness
|
150
|
136
|
|
death
|
3
|
2
|
|
Effective
|
447 (74.5)
|
462 (77.0)
|
0.360
|
Table 3. Comparison of bacterial clearance between generic group and brand-name group.
Variables, n (%)
|
Generic
(n=600)
|
Brand-name
(n=600)
|
P
|
Clearing
|
83
|
120
|
|
Not clearing
|
45
|
28
|
|
Replacement
|
236
|
290
|
|
Unknown
|
236
|
162
|
|
Bacterial clearance
|
83 (13.8)
|
120 (20.0)
|
<0.001
|
Table 4. Comparison of infection strain type stratification between generic group and brand-name group.
Variables, n (%)
|
Generic
(n=600)
|
Brand-name
(n=600)
|
P
|
Clearing
|
Not clearing
|
Clearing
|
Not clearing
|
Acinetobacter baumannii
|
1
|
27
|
1
|
17
|
0.747
|
Klebsiella pneumoniae
|
10
|
31
|
14
|
39
|
0.823
|
Pseudomonas aeruginosa
|
4
|
24
|
4
|
19
|
0.762
|
Escherichia coli
|
6
|
24
|
25
|
20
|
0.002
|
Enterobacter cloacae
|
0
|
7
|
7
|
12
|
0.077*
|
Carbapenem-resistant organism
|
2
|
18
|
3
|
53
|
0.472
|
Gram-negative bacteria but no specific strain name
|
34
|
80
|
47
|
118
|
0.809
|
gram-positive bacterium
|
41
|
118
|
59
|
235
|
0.161
|
Note: *Since n<40, use Fisher's exact probability test instead of χ2 test.
Table 5. Comparison of laboratory test indicators related to infection.
Variables, n (%)
|
Generic
(n=600)
|
|
Brand-name
(n=600)
|
|
P*
|
Pre-treatment
|
Post-treatment
|
P#
|
Pre-treatment
|
Post-treatment
|
p#
|
CRP
(mg/L)
|
92.5±75.2
|
65.0±2.8
|
<0.001
|
92.5±75.9
|
58.8±62.3
|
<0.001
|
0.188
|
PCT
(ng/ml)
|
1.9(0.3-11.3)
|
0.6(0.1-3.3)
|
<0.001
|
2.5(0.4-16.3)
|
0.7(0.2-3.5)
|
<0.001
|
0.260
|
WBC
(×10^9/L)
|
9.7(5.6-14.8)
|
7.5(5.0-11.2)
|
<0.001
|
10.5(6.3-16.0)
|
7.9(5.2-12.2)
|
<0.001
|
0.933
|
NEUT
(%)
|
76.4±23.2
|
71.8±21.0
|
<0.001
|
79.7±19.1
|
75.9±16.3
|
<0.001
|
0.264
|
Note: * To compare the difference in the degree of reduction of infection-related laboratory test indicators between the two groups, use t test or Wilcoxon non-parametric rank sum test; # To compare within the group, use t test or Wilcoxon non-parametric rank sum test
Safety
The incidence of adverse events was 4.2% for the brand-name group and 3.3% for the generic group (p = 0.447). The main types of adverse reactions are liver injury, kidney injury, and gastrointestinal symptoms (Table 6).
Table 6. Comparison of adverse reactions.
Variables, n (%)
|
Generic
(n=600)
|
Brand-name
(n=600)
|
P
|
Elevated total bilirubin
|
0
|
0
|
|
Liver injury
|
17
|
13
|
|
Renal injury
|
0
|
3
|
|
rash
|
0
|
1
|
|
Drug fever
|
0
|
1
|
|
Central nervous system symptoms
|
1
|
1
|
|
Gastrointestinal symptoms
|
2
|
6
|
|
total
|
20(3.3)
|
25(4.2)
|
0.447
|