BP | positive regulation of inflammatory response | 14 | CCL24, IL33, PLA2G2A, SERPINE1, IL18, LPL, IL17RB, FABP4, TRPV4, CCL4, S100A12, JAK2, CCL18, S100A9 | 1.46E-08 |
BP | signal transduction | 41 | GRIA2, CLIC3, CHRNA5, CABP2, CXCL1, TNFRSF11B, NTS, C3, CRHBP, GRB14, RGS1, CCL4, CXCR2, TNFSF10, TNFRSF17, PDE6A, ANXA9, JAK2, CCL18, CLIC2, FGB, LINGO1, CCL24, NMB, HLA-DRB4, KLRC3, ARRDC3, FGG, IGFBP2, IL19, C1ORF168, CXCL11, P2RX4, P2RX1, IL1B, NMU, ZNF536, IAPP, ZNF831, S100A9, PDE9A | 0.011286403 |
BP | inflammatory response | 25 | PTGER2, IL23R, CD5L, ALOX15, CXCR4, CXCL1, TNFRSF11B, C3, CRHBP, CYP26B1, CCL4, CXCR2, S100A12, BDKRB1, CCL18, GGT5, NGFR, CCL24, IL18, IL19, PPBP, CXCL11, IL1B, S100A9, IL17C | 1.32E-05 |
BP | immune response | 24 | SBSPON, CCL24, NGFR, HLA-DRB4, LIF, IL18, IL19, CXCL1, PRG4, TNFRSF11B, PPBP, C3, CXCL11, IFNG, SLPI, RGS1, IL1B, CCL4, TNFSF10, ENPP2, HLA-DRA, PKHD1L1, CCL18, FCGR1B | 1.90E-04 |
BP | oxidation-reduction process | 21 | EGLN3, STEAP4, ALOX15, AKR1B1, DHCR24, ADH7, TM7SF2, TPO, CYP26B1, TP53I3, CYP24A1, AKR1B10, AIFM1, DHRS9, MARC1, ALDH1A1, HHIPL2, TXNDC2, CYP2F1, CRYM, IDO1 | 0.071403488 |
BP | extracellular matrix organization | 16 | FGB, ITGA3, ELN, FGG, SPINK5, SERPINE1, LAMB1, TNFRSF11B, CYR61, COL19A1, COL4A2, COL5A1, COL5A2, BSG, COL9A3, MATN3 | 6.97E-05 |
CC | extracellular region | 87 | EPHB6, SERPINE2, ELN, SERPINE1, HP, CXCL1, SPINT2, HTN1, CYR61, NPPB, TNFSF10, PRSS8, TIMP1, FAM150B, PRSS2, CHGB, FGB, CPA3, CFC1B, EDN2, GIF, IGFBP3, IGFBP2, FGG, SPINK5, IL18, VSTM2L, IL19, VWDE, RNASE3, CEL, PRAP1, TUBA4A, IL17RB, UTS2B, PROCR, CLPS, IFNG, COL4A2, CRISPLD1, IL1B, SCG5, HHIPL2, IAPP, S100A9, MATN3, DSC3, COLEC11, CD5L, DEFB126, LPL, LCAT, TNFRSF11B, ADH7, NTS, STATH, COL19A1, C3, APELA, C6, NPVF, CCL4, APOF, S100A12, BRINP3, NGFR, BCHE, IL33, NMB, PSPN, PLA2G2A, LIF, IGFL2, LAMB1, PRG4, PPBP, NELL2, CXCL11, RAET1E, COL5A1, SST, COL5A2, NMU, COL9A3, LINC00305, NOTUM, IL17C | 7.76E-13 |
CC | extracellular space | 72 | SPON1, SERPINE2, POP1, SERPINE1, HP, WFDC1, AKR1B1, HSPB1, CXCL1, MSLN, NPPB, CRHBP, TNFSF10, ENPP2, CPXM1, PRSS8, TIMP1, PRSS2, RBBP8NL, FGB, CPA3, SERPINB4, EDN2, GIF, IGFBP3, IGFBP2, FGG, IL18, IL19, PCOLCE, RNASE3, CEL, ACTA1, IFNG, SLPI, IL1B, IAPP, PKHD1L1, S100A9, SERPINB12, CDNF, CD5L, DPT, LPL, LCAT, TNFRSF11B, CST6, C3, TPO, APELA, RELN, FLRT3, CCL4, SERPINH1, IL36RN, CCL18, CPA4, CCL24, IL33, PLA2G2A, LIF, LAMB1, PPBP, KLK11, IFNW1, COLQ, CXCL11, SST, IL17C, CBLN2, BPIFC, UMODL1 | 2.06E-10 |
CC | plasma membrane | 123 | EPHB6, STEAP4, IL23R, TRAC, SERPINE1, PCDH11X, OR2M4, AQP4, SLCO6A1, SPINT2, RGS4, CDH3, GRB14, RGS1, BSG, MAGEA1, ENPP2, PRSS8, SLC16A9, CA14, RGS6, RGS7, GPR78, ACSL1, ARRDC3, TAAR2, SLC51A, SYTL5, PROCR, GPR160, RHCG, S100A9, DGKI, DSC3, GPM6A, GRIA2, CALCRL, CHRNA5, NPR3, SDC3, ALOX15, CABP2, LPL, TNFRSF11B, CD1C, PPL, CPLX3, C3, TPO, FLRT3, TNFRSF17, S100A12, KCNN2, STXBP6, SCN3A, RAP1GAP2, GGT5, NGFR, SYT4, ATP8B4, HLA-DRB4, RAB4B, CNTN6, HTR1A, SLC6A6, MARCO, RAET1E, TRPV4, HLA-DRA, GAPT, RYR1, PSCA, SH3KBP1, GPR21, GPR22, FHL1, HSPB1, MSLN, UCHL1, DNER, CA4, BDKRB1, CLEC1B, FGB, GPR37, FCER1G, TNFRSF12A, MME, ITGA3, FGG, PTH2R, HTR3B, IL17RB, VN1R1, RGS18, PTGER2, CXCR4, LRP2, GNAI1, RELN, ACVR1C, DNAJB4, HAS1, CXCR2, SCN7A, FLNC, PDE6A, FCGR1B, SLC17A3, KCNJ4, OR1D5, LINGO1, KCNJ10, PLA2G2A, COLQ, VMP1, SLC8A3, KRT19, CYP24A1, P2RX4, GPAM, P2RX1, SLC28A3 | 0.004657944 |
CC | extracellular exosome | 100 | STEAP4, SERPINE1, PCDH11X, HP, MYLK4, CYSRT1, PEBP4, BSG, TNFSF10, PRSS8, RPS11, EYS, IGFBP3, IGFBP2, SPINK5, PCOLCE, CEL, RNASE3, TUBA4A, PROCR, CLPS, COL4A2, SLPI, CRISPLD1, RHCG, S100A9, GPM6A, SMIM1, NPR3, DPT, ANKRD19P, LPL, SDSL, PPL, ACMSD, C3, C6, SERPINH1, PCK1, SPHKAP, LRRN4, TP53I3, AKR1B10, COL5A1, HLA-DRA, ACO1, BEX5, RYR1, CLIC3, HSP90AB1, PSCA, AKR1B1, HSPB1, RND3, KHK, UCHL1, UPK1B, CRTAC1, CA4, MAN1A1, TIMP1, ANXA9, CTSE, FGB, SERPINB4, MME, ITGA3, PLLP, MUM1L1, FGG, IL18, ACTA1, ANGPTL6, IL1B, ALDH1A1, ASPA, SERPINB12, FH, CD5L, ITLN1, LCAT, CXCR4, SLC5A12, LRP2, CST6, GNAI1, DNAJB4, MAL2, CRYM, PLA2G2A, LAMB1, PDZK1IP1, KLK11, KRT19, KRT18, FABP4, P2RX4, GSTA3, QPCT, MNDA | 3.28E-05 |
CC | integral component of plasma membrane | 55 | EPHB6, RYR1, STEAP4, PCDH11X, AQP4, SLCO6A1, CLDN1, TM7SF2, MILR1, UPK1B, BSG, TNFSF10, ENPP2, BDKRB1, CNGA4, CLEC1B, TMEM150B, FCER1G, GPR37, GPR34, MME, INSRR, ATP1B4, PTH2R, CEL, HTR3B, IL17RB, PROCR, RHCG, GRIA2, CALCRL, PTGER2, NPR3, SLC5A12, TNFRSF11B, CD1C, TPO, FLRT3, HAS1, CXCR2, SLC17A3, NGFR, HLA-DRB4, KCNJ10, LRRN4, HTR1A, SLC8A3, SLC6A6, MARCO, P2RX4, P2RX1, TRPV4, HLA-DRA, EVI2B, SLC28A3 | 4.32E-04 |
CC | cell surface | 24 | EPHB6, FGB, NGFR, HSP90AB1, FCER1G, TNFRSF12A, ITGA3, SDC3, DEFB126, FGG, CXCR4, LPL, CEL, HTR3B, MSLN, IL17RB, PROCR, TPO, TRPV4, CA4, CXCR2, HLA-DRA, KCNN2, ANXA9 | 0.005981684 |
MF | calcium ion binding | 34 | RYR1, FBN3, PCDH11X, CABP2, LRP2, CALB2, CAPN8, TPO, PPP3R1, CDH3, CRTAC1, DNER, ENPP2, S100A12, MAN1A1, ANXA9, PRSS2, EYS, SYT4, S100A2, PLA2G2A, EDEM2, VWDE, SYTL5, NELL2, MEX3B, CAPN12, MYL2, MYL3, CASQ1, S100A9, MATN3, DSC3, UMODL1 | 1.74E-04 |
MF | receptor binding | 18 | FGB, SERPINE2, PSPN, FGG, IGFBP2, SERPINE1, LIF, LPL, CXCL1, PTK6, C3, NPPB, P2RX4, NMU, TNFSF10, APOF, IAPP, JAK2 | 0.00412687 |
MF | cytokine activity | 13 | IL33, LIF, IL18, IL19, TNFRSF11B, IFNW1, IFNG, IL1B, CCL4, TNFSF10, IL36RN, TIMP1, IL17C | 9.15E-04 |
MF | catalytic activity | 10 | BCHE, FH, PFKFB3, RSAD2, AADAC, ACSL1, MARC1, ODC1, ACSBG1, CEL | 0.033310636 |
MF | serine-type endopeptidase inhibitor activity | 9 | SERPINB4, SERPINB12, SERPINE2, SLPI, SPINK5, SERPINE1, SERPINH1, WFDC1, SPINT2 | 0.001974472 |
MF | extracellular matrix structural constituent | 8 | FBN3, COL4A2, COL5A1, ELN, COL5A2, LAMB1, MATN3, COL19A1 | 9.47E-04 |