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Research article
Wenyi Guo
Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1737-1217
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Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).
Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.
Results: Forty-six non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma（SG）patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients, 2 exhibit bilateral PWS and unilateral glaucoma. Thus the two eyes of each person were divided into NGPWS group and SG group respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and contralateral eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and contralateral eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 12 eyes (50%) with choroidal hemangiomas exhibited post-operative posterior segment complications.
Conclusions: Non-glaucoma PWS and SWS secondary glaucoma patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SWS secondary glaucoma patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.
Keywords
Sturge-Weber Syndrome, Port-wine Stain, Glaucoma, Choroidal Hemangiomas, Optical Coherence Tomography, Complications
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CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
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Editorial decision: Accept
On 24 Nov, 2020
Editor assigned
On 23 Nov, 2020
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On 23 Nov, 2020
Editor invited
On 23 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 19 Nov, 2020
Editor assigned
On 16 Nov, 2020
Submission checks complete
On 16 Nov, 2020
Editor invited
On 16 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 12 Nov, 2020
Reviewer #2 agreed
On 28 Sep, 2020
Reviewers invited
Invitations sent on 08 Sep, 2020
Reviewer #1 agreed
On 08 Sep, 2020
Review #1 received
Received 08 Sep, 2020
Editor assigned
On 07 Sep, 2020
Submission checks complete
On 06 Sep, 2020
Editor invited
On 06 Sep, 2020
Version 1
Posted 28 Jul, 2020
No comments provided
Review #2 received
Received 28 Aug, 2020
Editorial decision: Minor revision
On 28 Aug, 2020
Review #1 received
Received 18 Aug, 2020
Reviewer #2 agreed
On 07 Aug, 2020
Reviewers invited
Invitations sent on 04 Aug, 2020
Reviewer #1 agreed
On 04 Aug, 2020
Editor assigned
On 21 Jul, 2020
Submission checks complete
On 20 Jul, 2020
Editor invited
On 20 Jul, 2020
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See the published version of this preprint at BMC Ophthalmology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Wenyi Guo
Shanghai 9th Peoples Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Corresponding Author
ORCiD: https://orcid.org/0000-0002-1737-1217
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Ophthalmology.
No community comments so far
Editorial decision: Accept
On 24 Nov, 2020
Editor assigned
On 23 Nov, 2020
Submission checks complete
On 23 Nov, 2020
Editor invited
On 23 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 19 Nov, 2020
Editor assigned
On 16 Nov, 2020
Submission checks complete
On 16 Nov, 2020
Editor invited
On 16 Nov, 2020
No comments provided
Editorial decision: Minor revision
On 12 Nov, 2020
Reviewer #2 agreed
On 28 Sep, 2020
Reviewers invited
Invitations sent on 08 Sep, 2020
Reviewer #1 agreed
On 08 Sep, 2020
Review #1 received
Received 08 Sep, 2020
Editor assigned
On 07 Sep, 2020
Submission checks complete
On 06 Sep, 2020
Editor invited
On 06 Sep, 2020
Version 1
Posted 28 Jul, 2020
No comments provided
Review #2 received
Received 28 Aug, 2020
Editorial decision: Minor revision
On 28 Aug, 2020
Review #1 received
Received 18 Aug, 2020
Reviewer #2 agreed
On 07 Aug, 2020
Reviewers invited
Invitations sent on 04 Aug, 2020
Reviewer #1 agreed
On 04 Aug, 2020
Editor assigned
On 21 Jul, 2020
Submission checks complete
On 20 Jul, 2020
Editor invited
On 20 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Ophthalmology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Ophthalmology.
Background: To evaluate the choroidal changes in Sturge-Weber syndrome (SWS) secondary glaucoma and non-glaucoma port-wine stain (PWS) patients by enhanced depth imaging optical coherence tomography (EDI-OCT).
Methods: SWS and PWS patients who were over 3 years old and treated or screened at our ophthalmology department were included in the study. Baseline demographics, EDI-OCT and fundus photography data were collected from all patients.
Results: Forty-six non-glaucoma PWS (NGPWS) patients and 35 SWS secondary glaucoma（SG）patients were included, with mean ages of 16.52±13.63 and 13.94±8.27 years, respectively (p>0.05). Among these patients, 2 exhibit bilateral PWS and unilateral glaucoma. Thus the two eyes of each person were divided into NGPWS group and SG group respectively. Twenty-one eyes had choroidal hemangiomas and 7 eyes had excessive thickening of the choroid without choroidal hemangiomas. Choroidal hemangiomas were only observed in ipsilateral eyes of SG patients. The choroidal thicknesses of the ipsilateral and contralateral eyes of NGPWS patients were 358.10±117.40 μm (45 eyes) and 288.20±79.04 μm (41 eyes), respectively (p<0.05). The choroidal thicknesses of the ipsilateral and contralateral eyes of SG patients were 511.40±242.10 μm (15 eyes) and 283.90±92.27 μm (29 eyes), respectively (p<0.05). Significant differences were found between the ipsilateral eyes of SWS and PWS patients (p<0.05). Six of 12 eyes (50%) with choroidal hemangiomas exhibited post-operative posterior segment complications.
Conclusions: Non-glaucoma PWS and SWS secondary glaucoma patients had a thicker choroid in the ipsilateral eye. The trend was even more pronounced in SWS secondary glaucoma patients. Choroidal hemangiomas were only found in the ipsilateral eyes of SG. In addition, choroidal hemangioma was a risk factor for post-operative posterior segment complications in SWS patients.
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