Table 1 presents the demographic characteristics of both groups. There were no significant differences in the baseline characteristics, including age; BMI; Years of infertility; and basal FSH and LH between the two groups
Groups
|
Group1 (n = 149)
|
Group2 (n = 167)
|
P
|
Age (years)
|
32.56±3.54
|
33.22±3.55
|
0.104
|
Years of infertility
|
3.31±2.46
|
3.54±3.53
|
0.498
|
Body mass index
|
24.16±4.38
|
23.94±4.37
|
0.658
|
bFSH/bLH
|
1.80±1.14
|
2.03±1.76
|
0.195
|
*Data expressed as mean ± SD, or number (percentage).
Table 2 presents the demographic characteristics of four subgroups. There were no significant differences in the baseline characteristics, including age; BMI; Years of infertility; and basal FSH and LH between the four subgroups.
Subgroup
|
Subgroup A1(n = 107)
|
Subgroup A2(n = 73)
|
Subgroup B1(n = 42)
|
Subgroup B2(n = 94)
|
P
|
Years of infertility
|
2.96±1.82
|
3.29±1.97
|
4.14±3.48
|
3.79±4.39
|
>0.05
|
Body mass index
|
23.77±4.79
|
22.75±5.48
|
24.10±3.24
|
23.85±5.81
|
>0.05
|
bFSH/bLH
|
1.83±1.14
|
2.06±2.01
|
1.80±1.14
|
1.93±1.53
|
>0.05
|
*Subgroup A1、Subgroup A2 basic data p values were:0.257、0.187、0.319
*Subgroup B1、Subgroup B2 basic data p values were:0.644、0.793、0.618
*Data expressed as mean ± SD, or number (percentage).
Table 3 presents the demographic characteristics of four subgroups. There were no significant differences in the baseline characteristics, including age; BMI; Years of infertility; and basal FSH and LH between the four subgroups.
Subgroup
|
Subgroup C1(n = 94)
|
Subgroup C2(n = 114)
|
Subgroup D1(n = 55)
|
Subgroup D2(n = 53)
|
P
|
Years of infertility
|
3.44±2.58
|
3.12±2.19
|
3.05±2.22
|
4.53±5.32
|
>0.05
|
Age (years)
|
33.62±4.44
|
34.32±4.05
|
32.95±5.37
|
34.64±4.35
|
>0.05
|
bFSH/bLH
|
1.77±1.05
|
2.09±1.90
|
1.91±1.27
|
1.80±1.38
|
>0.05
|
*Subgroup C1、Subgroup C2 basic data p values were:0.344、0.237、0.140
*Subgroup D1、Subgroup D2 basic data p values were:0.066、0.075、0.683
*Data expressed as mean ± SD, or number (percentage).
Table 4 Gonadotropin consumption was significantly lower (2200.34±915.54 IU vs. 2571.68±905.58 IU, p < 0.001) and the stimulation duration, the number of retrieved oocytes and available embryos were significantly larger(9.59±2.12 vs. 9.01±2.67, p = 0.036;8.17±4.10 vs. 7.07±4.05, p = 0.017;2.96±2.03 vs. 2.52±1.62, p = 0.036) in Group 1 than in Group 2, while the usage days of Cetrorelix did not significantly differ between the groups. Meanwhile, fertilized oocytes and the number of superior-quality embryos did not significantly differ between the two groups.
Groups
|
Group1 (n = 149)
|
Group2 (n = 167)
|
P
|
Cetrorelix usage days
|
3.44±1.52
|
3.72±1.71
|
0.115
|
Gn usage days
|
9.59±2.12
|
9.01±2.67
|
0.036
|
Gn total
|
2200.34±915.54
|
2571.68±905.58
|
0.000
|
retrieved oocytes
|
8.17±4.10
|
7.07±4.05
|
0.017
|
fertilized oocytes
|
4.89±3.06
|
4.47±3.00
|
0.220
|
available embryos
|
2.96±2.03
|
2.52±1.62
|
0.036
|
superior-quality embryos
|
0.80±1.15
|
0.73±0.97
|
0.568
|
*Data expressed as mean ± SD, or number (percentage).
Table 5 Gonadotropin consumption was significantly lower (2201.40±896.53 IU vs. 2498.29±811.80 IU,2197.62±973.51 IU vs. 2628.67±972.67 IU, p < 0.05) in subgroup A1/B1 than in subgroup A2/B2.Furthermore,the number of retrieved oocytes, fertilized oocytes, available embryos and the number of uperior-quality embryos did not significantly differ between the two same subgroups.
Subgroup
|
Subgroup A1(n = 107)
|
Subgroup A2(n = 73)
|
Subgroup B1(n = 42)
|
Subgroup B2(n = 94)
|
P
|
Cetrorelix usage days
|
3.52±1.57
|
3.68±1.68
|
3.21±1.39
|
3.76±1.73
|
>0.05
|
Gn usage days
|
9.71±1.81
|
9.52±2.83
|
9.29±2.76
|
8.62±2.51
|
>0.05
|
Gn total
|
2201.40±896.53
|
2498.29±811.80
|
2197.62±973.51
|
2628.67±972.67
|
<0.05
|
retrieved oocytes
|
8.37±4.21
|
9.07±3.95
|
5.88±3.57
|
6.06±3.63
|
>0.05
|
fertilized oocytes
|
5.38±3.12
|
5.16±3.31
|
3.64±2.51
|
3.94±2.64
|
>0.05
|
available embryos
|
2.85±1.81
|
3.21±2.24
|
2.33±1.20
|
2.27±1.42
|
>0.05
|
superior-quality embryos
|
0.86±1.27
|
0.73±0.93
|
0.64±0.76
|
0.73±1.00
|
>0.05
|
*Subgroup A1、Subgroup A2 experimental data P values were:0.510、0.584、0.022、0.253、0.653、0.259、0.443
*Subgroup B1、Subgroup B2 experimental data P values were:0.077、0.166、0.018、0.786、0.544、0.790、0.598
*Data expressed as mean ± SD, or number (percentage).
Table 6 Gonadotropin consumption was significantly lower (2073.14±934.23 IU vs. 2452.26±896.32 IU,2417.73±847.28 IU vs. 2828.54±879.56 IU, p < 0.05) in subgroup C1/D1 than in subgroup C2/D2.However, the number of retrieved oocytes was significantly larger(8.24±4.04 vs. 6.83±3.92, p = 0.012) in subgroup C1 than in subgroup C2.
Subgroup
|
Subgroup C1(n = 94)
|
Subgroup C2(n = 114)
|
Subgroup D1(n = 55)
|
Subgroup D2(n = 53)
|
P
|
Cetrorelix usage days
|
3.35±1.50
|
3.63±1.60
|
3.58±1.55
|
3.92±1.91
|
>0.05
|
Gn usage days
|
9.28±1.79
|
8.86±2.93
|
10.13±2.52
|
9.34±2.06
|
>0.05
|
Gn total
|
2073.14±934.23
|
2452.26±896.32
|
2417.73±847.28
|
2828.54±879.56
|
<0.05
|
retrieved oocytes
|
8.24±4.04
|
6.83±3.92
|
8.05±4.22
|
7.58±4.31
|
C<0.05
D>0.05
|
fertilized oocytes
|
5.00±2.94
|
4.35±2.83
|
4.71±3.26
|
4.74±3.36
|
>0.05
|
available embryos
|
3.02±2.04
|
2.61±1.65
|
2.85±2.03
|
2.34±1.56
|
>0.05
|
superior-quality embryos
|
0.79±0.98
|
0.70±0.94
|
0.82±1.40
|
0.79±1.03
|
>0.05
|
*Subgroup C1、Subgroup C2 experimental data P values were:0.198、0.229、0.003、0.012、0.107、0.106、0.523
*Subgroup D1、Subgroup D2 experimental data P values were:0.307、0.788、0.015、0.568、0.967、0.143、0.914
*Data expressed as mean ± SD, or number (percentage).
Table 7 there was a total of 316 fresh embryo transfer cycles: 149 in Group 1 and 167 in Group 2. The clinical pregnancy rate (36.2 vs. 37.1%) and live production rate(30.20 vs. 31.74%)were slightly higher in Group 2 than in Group 1, but the differences were not significant. The incidence of OHSS was not analyzed because some of the patients did not received fresh embryos in order to avoid OHSS.
Groups
|
Group1 (n = 149)
|
Group2 (n = 167)
|
P
|
clinical pregnancy rate
|
36.20%
|
37.10%
|
0.871
|
live production rate
|
30.20%
|
31.74%
|
0.768
|
*Data expressed as mean ± SD, or number (percentage).
Table 8 in four subgroups grouped by age, the clinical pregnancy rate (44.86 vs. 38.36%) was slightly higher in subgroup A1 than in subgroup A2, but the difference was not significant.
Subgroup
|
Subgroup A1(n = 107)
|
Subgroup A2(n = 73)
|
Subgroup B1(n = 42)
|
Subgroup B2(n = 94)
|
P
|
clinical pregnancy rate
|
44.86%
|
38.36%
|
21.43%
|
37.23%
|
>0.05
|
live production rate
|
35.51%
|
35.62%
|
16.67%
|
28.72%
|
>0.05
|
*Subgroup A1、Subgroup A2 pregnancy outcome P values were:0.386、0.989
*Subgroup B1、Subgroup B2 pregnancy outcome P values were:0.069、0.134
*Data expressed as mean ± SD, or number (percentage).
Table 9 there was a total of 208 fresh embryo transfer cycles in the BMI below 25 group: 94 in subgroup C1 and 114 in subgroup C2.
Subgroup
|
Subgroup C1(n = 94)
|
Subgroup C2(n = 114)
|
Subgroup D1(n = 55)
|
Subgroup D2(n = 53)
|
P
|
clinical pregnancy rate
|
34.04%
|
43.86%
|
45.45%
|
24.53%
|
C>0.05
D<0.05
|
live production rate
|
27.66%
|
35.96%
|
34.55%
|
22.64%
|
>0.05
|
*Subgroup C1、Subgroup C2 pregnancy outcome P values were:0.149、0.202
*Subgroup D1、Subgroup D2 pregnancy outcome P values were:0.023、0.172
*Data expressed as mean ± SD, or number (percentage).