Acknowledgments: We acknowledge the collaboration of the patients who participated in this study and the collaboration of Marie Helène Fabre and Dr Clémence Leung for patients’ selection.
Author Roles:
CAA conceptualized, organized, executed the study, and wrote the first draft of the manuscript.
CL organized and executed the study and wrote the first draft of the manuscript.
SG organized and executed the study and wrote the first draft of the manuscript.
DR organized and executed the study and wrote the first draft of the manuscript.
CC ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript.
VR designed, ran and reviewed the statistical analyses, and reviewed the draft of the manuscript.
CT conceptualized the study, ran the formal analysis and reviewed the draft of the manuscript.
RB conceptualized and executed the study, and reviewed the draft of the manuscript.
FO-M conceptualized and executed the study, and reviewed the draft of the manuscript.
CB-C conceptualized and executed the study, and reviewed the draft of the manuscript.
OR conceptualized and executed the study and reviewed the draft of the manuscript.
AB ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript.
EH ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
MZ ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
MGR ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
AR ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
GI ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
LL ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
JLH ran the formal analysis and did the review and critique of the statistical analysis and reviewed the draft of the manuscript
MF conceptualized, organized, executed the study, and reviewed the first draft of the manuscript.
All authors read and approved the final manuscript.
Funding Sources and Conflict of Interest
This work was partly supported by the ARI-CHU Project (Toulouse University Hospital).
Financial Disclosures for the previous 12 months
Carlo Alberto Artusi received speaker honoraria from Zambon, Bial, Lusofarmaco.
Domiziana Rinaldi received travel grants from AbbVie.
Mario Giorgio Rizzone received grant support and speaker honoraria from UCB.
Maurizio Zibetti received speaker honoraria from Medtronic, Zambon Pharma and AbbVie.
Leonardo Lopiano received honoraria for lecturing and travel grants from Medtronic, UCB Pharma, and AbbVie.
Alberto Romagnolo has received speaker honoraria from Zambon.
Claudia Ledda, Corrado Campisi, Raquel Barbosa, Amaury De Barros, Silvia Gallo, Estelle Harroch, Vanessa Rousseau, Clarie Thalamas, Gabriele Imbalzano, Jean Luc Houeto report no disclosures.
Christine Brefel-Courbon has received research grant from Association France Parkinson, and fees for lectures and consultancies from Aguettant, Orkyn, NHC, Zambon and AbbVie.
Olivier Rascol has acted as a scientific advisor for drug companies developing antiparkinsonian medications (Abbott, Abbvie, Acorda, Adamas, BIAL, Biogen, Boehringer-Ingelheim, Cynapsus, GSK, Impax, Merck, Osmotica, Oxford-Biomedica, Lundbeck, Novartis, Prexton, Servier, Sunovion, TEVA, UCB, Zambon).
Fabienne Ory-Magne has received honoraria for serving as an advisory board member from Abbvie, Medtronic, Orphalan, Aguettant and Orkyn, and for consultancy activities from Aguettant, Abbvie, Orphalan, Ellivie, Homeperf and Orkyn.
Margherita Fabbri received Honoraria to speak from AbbVie, ORKYN, and BIAL, consultancies from BIAL and LVL Medical; Grant from France Parkinson, HORIZON 2022 and MSA Coalition.
Data availability statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.