Comparison of Cytokine Levels in the Aqueous Humor of Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration Patients
Background
The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cytokine levels in the aqueous humor of eyes with PCV, nAMD and control.
Methods
The present case control study included 49 treatment-naïve eyes from 49 patients (PCV 24, nAMD 11, and cataract 14 eyes). Totally 34 angiogenic and inflammatory cytokines in the aqueous humor were measured by Luminex bead-based multiplex array.
Results
After adjusting for gender and age by multivariate logistic analysis, concentrations of IL-31, LIF, SDF1-α, VEGF-A, VEGF-D were significantly higher in eyes with nAMD or PCV compared with control eyes (all P<0.05, times in nAMD: 59.5, 6.0, 7.0, 4.5, 5.6, respectively, times in PCV: 51.9, 5.21, 6.6, 4.0, 5.1, respectively ), and concentrations of HGF, IP-10, MCP-1, IL-13 were significantly lower in eyes with nAMD or PCV than in control eyes (all P<0.05, times in nAMD: 2.6, 2.0, 4.5, 4.7, respectively, times in PCV: 1.9, 3.0, 3.0, 2.8, respectively), but none of the 34 cytokines, including VEGF and IL-8, showed significantly different between eyes with nAMD and PCV.
Conclusions
Various cytokines involved in inflammation and angiogenesis including elevated IL-31, LIF, SDF1-α, VEGF-A, VEGF-D might be involved in the pathogenesis of nAMD or PCV. None of the 34 cytokines may help to differentiate nAMD and PCV.
Posted 19 Dec, 2019
On 08 Jan, 2020
On 14 Dec, 2019
On 13 Dec, 2019
On 10 Dec, 2019
On 27 Nov, 2019
Received 27 Nov, 2019
On 25 Nov, 2019
Invitations sent on 24 Nov, 2019
On 21 Nov, 2019
On 20 Nov, 2019
On 20 Nov, 2019
Received 14 Nov, 2019
On 14 Nov, 2019
On 14 Nov, 2019
Received 14 Nov, 2019
On 12 Oct, 2019
Received 26 Aug, 2019
On 23 Aug, 2019
Invitations sent on 22 Aug, 2019
On 21 Aug, 2019
On 21 Aug, 2019
On 20 Aug, 2019
On 20 Aug, 2019
Comparison of Cytokine Levels in the Aqueous Humor of Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration Patients
Posted 19 Dec, 2019
On 08 Jan, 2020
On 14 Dec, 2019
On 13 Dec, 2019
On 10 Dec, 2019
On 27 Nov, 2019
Received 27 Nov, 2019
On 25 Nov, 2019
Invitations sent on 24 Nov, 2019
On 21 Nov, 2019
On 20 Nov, 2019
On 20 Nov, 2019
Received 14 Nov, 2019
On 14 Nov, 2019
On 14 Nov, 2019
Received 14 Nov, 2019
On 12 Oct, 2019
Received 26 Aug, 2019
On 23 Aug, 2019
Invitations sent on 22 Aug, 2019
On 21 Aug, 2019
On 21 Aug, 2019
On 20 Aug, 2019
On 20 Aug, 2019
Background
The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cytokine levels in the aqueous humor of eyes with PCV, nAMD and control.
Methods
The present case control study included 49 treatment-naïve eyes from 49 patients (PCV 24, nAMD 11, and cataract 14 eyes). Totally 34 angiogenic and inflammatory cytokines in the aqueous humor were measured by Luminex bead-based multiplex array.
Results
After adjusting for gender and age by multivariate logistic analysis, concentrations of IL-31, LIF, SDF1-α, VEGF-A, VEGF-D were significantly higher in eyes with nAMD or PCV compared with control eyes (all P<0.05, times in nAMD: 59.5, 6.0, 7.0, 4.5, 5.6, respectively, times in PCV: 51.9, 5.21, 6.6, 4.0, 5.1, respectively ), and concentrations of HGF, IP-10, MCP-1, IL-13 were significantly lower in eyes with nAMD or PCV than in control eyes (all P<0.05, times in nAMD: 2.6, 2.0, 4.5, 4.7, respectively, times in PCV: 1.9, 3.0, 3.0, 2.8, respectively), but none of the 34 cytokines, including VEGF and IL-8, showed significantly different between eyes with nAMD and PCV.
Conclusions
Various cytokines involved in inflammation and angiogenesis including elevated IL-31, LIF, SDF1-α, VEGF-A, VEGF-D might be involved in the pathogenesis of nAMD or PCV. None of the 34 cytokines may help to differentiate nAMD and PCV.