Conflict of Interest
Luis Augusto Rohde has received grant or research support from National Council for Scientific and Technological Development (CNPq) and United States National Institutes of Health grant R01MH120482, authorship royalties from Oxford Press and ArtMed, consulting fees from Adium, Apsen, Medice, Novartis/Sandoz and Shire/Takeda, served on the speakers’ bureau of Abdi Ibrahim, Abbott, Aché, Adium, Apsen, Bial, Medice, Novartis/Sandoz, Pfizer/Upjohn/Viatris, and Shire/Takeda, participated on a advisory board in Adium, Apsen, Medice, Novartis/Sandoz, and Shire/Takeda, received supoort for attending meetings from Stavros Niarchos Foundation and had leadership role in International Association of Child and Adolescent Psychiatry and Allied Disciplines.
Ary Gadelha has received grant or research support from, served as a consultant to, and served on the speakers’ bureau of Aché, Daiichi-Sankyo, Teva, Lundbeck, Cristalia, and Janssen, and received consulting fees from Teva and Daiichi-Sankyo in the last three years.
Pedro Mario Pan received payment or honoraria for lectures and presentations in educational events for Sandoz, Daiichi Sankyo, Eurofarma, Abbot, Libbs, Instituto Israelita de Pesquisa e Ensino Albert Einstein, Instituto D’Or de Pesquisa e Ensino.
Funding
This work is supported by the National Institute of Developmental Psychiatry for Children and Adolescents, a science and technology institute funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; National Council for Scientific and Technological Development; grant numbers 573974/2008-0 and 465550/2014-2) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; Research Support Foundation of the State of São Paulo; grant number 2008/57896-8, 2014/50917-0 and 2021/05332-8) to the National Institute of Development Psychiatric for Children and Adolescent (INPD). This work was also funded by the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no 337673.
Ethical standards
This study was approved by the ethics committee of the University of São Paulo [IORG0004884/National Council of Health Registry number (CONEP): 15.457/Project IRB registration number: 1132/08] and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Participation in all phases of the study was voluntary and written consent and assent were obtained from the caregivers and youths, respectively.
Authors' contributions
IMP: Conceptualisation, study design, data curation, formal analysis, investigation, writing – original draft, and writing – review & editing.
JVA: Investigation, writing – original draft, and writing – review & editing.
JPGP: Investigation, writing – original draft, and writing – review & editing.
IT: Formal analysis and writing – review & editing.
ECM: Writing – review & editing, funding acquisition, data curation, study design and data collection.
PMP: Writing – review & editing, data curation, study design and data collection.
AG: Writing – review & editing, data curation, study design and data collection.
LAR: Conceptualization, writing – review & editing, funding acquisition, data curation, study design and data collection.
GAS: Conceptualisation, supervision, funding acquisition, data curation, study design, data collection, investigation, writing – original draft, and writing – review & editing.
MSH: Conceptualisation, study design, data curation, formal analysis, investigation, methodology, project administration, validation, visualisation, writing – original draft, and writing – review & editing.
IMP, MSH and GAS directly accessed and verified the underlying data reported in the manuscript.
All authors read and approved the final version of the manuscript and had full access to all the data in the study and had final responsibility for the decision to submit for publication. Everyone who meets the criteria is included as an author.
Data availability
Data dictionary is available at https://osf.io/ktz5h/wiki/Data%20Dictionaries/ and https://osf.io/w3jr4 to direct download. Individual-level data is available upon request to the Brazilian High-Risk Cohort Study research committee, by following the instructions and filling the research form available at https://osf.io/ktz5h/wiki/home/. Study design and ethical details can be found elsewhere [14].
Consent for publication
The manuscript final version and publication is approved by all authors.