Background
Whether hyperglycemia affects the prognosis of patients with acute large vessel occlusion (ALVO) is still controversial. In addition, hyperglycemia is increasingly common, so we analyzed the impact of fasting plasma glucose level on functional outcome after reperfusion in patients with ALVO.
Methods
The data of 2056 patients were retrospectively analyzed. The relationship between the average fasting blood glucose 24 hours after recanalization and prognosis was analyzed.
Results
(1) 892 patients were finally enrolled by nearest neighbor matching method. After matching, there were no significant differences in gender, age, preoperative modified Rankin Scale (preoperative-mRS), and diabetes history between the two groups. (2) With 90-day modified Rankin Scale (90-day mRS) as the outcome variable, comparing the factors of good prognosis group and poor prognosis group showed that the older the age, the higher the proportion of poor prognosis (P = 0.014); Patients with diabetes had a higher proportion of poor prognosis (30.8% vs 14.5%, P < 0.001). The MFBG in the poor prognosis group was higher than that in the good prognosis group (P < 0.001). (3) Cox regression analysis showed that: MFBG is an independent risk factor for poor prognosis; When MFBG was > 7 mmol/L, the rate of poor prognosis was 1.139 times higher than MFBG was ≤ 7 mmol/L [OR (95% CI) = 1.139 (1.055,1.229), P < 0.001].
Conclusion
Fasting blood glucose levels 24 hours after reperfusion in patients with ALVO can serve as a predictive marker for prognosis. Controlling blood glucose levels below 7 mmol/L may reduce the rate of adverse outcomes in these patients.
Trial registration
This study is a multicenter retrospective study, there is no registration were retrospectively.