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Research article
A Post-market, Multi-vessel Evaluation of the Imaging of Peripheral Arteries for Diagnostic PurposeS Comparing Optical Coherence TomogrAphy and INtravascular Ultrasound Imaging (SCAN)
Edward Pavillard
Pennsylvania Vascular Institute
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7149-3269
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Intravascular imaging plays an important part in diagnosis of vascular conditions and providing insight for treatment strategy. Two main imaging modalities are intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The objective of this study was to prove non-inferiority of OCT imaging to IVUS images in matched segments of peripheral vessels in patients with suspected peripheral vascular disease. Methods: The SCAN study was a prospective, non-inferiority clinical study of matched IVUS and OCT images collected along defined segments of peripheral vessels from twelve subjects (mean age 68 10.3 years; 10 men) displaying symptoms of vascular disease. Luminal diameters were measured by both imaging systems at the distal, middle, and proximal points of the defined segments. Three blinded interventional radiologists evaluated the quality of both imaging modalities in identifying lMann-Whitney-Wilcoxon testing. Intrareader reproducibility was calculated by intraclass correlation (ICC) analysis. Results: The mean scoringof plaque, calcification, and vascular stent struts by the three readers was significant better in terms of image quality for OCT than IVUS (p<0.001, p=0.001, p=0.004, respectively). The mean scores of vessel wall component visibility and artifacts generated by the two imaging systems were not significantly different (p=0.19, p=0.07, respectively). Mean vessel luminal diameter and area at three specific locations within the vessels were not significantly different between the two imaging modalities. No patient injury, adverse effect or device malfunction were noted during thestudy. Conclusions: Imaging byOCT provides the physician with better visualization of some vessel and plaque chacteristics, but both IVUS and OCT imaging are safe and effective methods of examining peripheral vessels in order to perform diagnostic assessment of peripheral vessels and provide information necessary for the treatment strategy of peripheral artery disease.
Keywords
intravascular imaging, IVUS, OCT, plaque, diagnosis, treatment strategy
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CURRENT STATUS: Under Review
Version 2
Posted 09 Jan, 2020
No community comments so far
Review #1 received
Received 29 Jan, 2020
Reviewer #1 agreed
On 08 Jan, 2020
Reviewers invited
Invitations sent on 08 Jan, 2020
Editor assigned
On 06 Jan, 2020
Submission checks complete
On 05 Jan, 2020
Editor invited
On 05 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 18 Dec, 2019
Reviewer #3 agreed
On 02 Dec, 2019
Review #1 received
Received 27 Oct, 2019
Review #2 received
Received 27 Oct, 2019
Reviewer #2 agreed
On 14 Oct, 2019
Reviewer #1 agreed
On 10 Oct, 2019
Reviewers invited
Invitations sent on 09 Oct, 2019
Editor assigned
On 30 Aug, 2019
Submission checks complete
On 29 Aug, 2019
Editor invited
On 29 Aug, 2019
First submitted
On 26 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
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This preprint is under consideration at BMC Medical Imaging. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
A Post-market, Multi-vessel Evaluation of the Imaging of Peripheral Arteries for Diagnostic PurposeS Comparing Optical Coherence TomogrAphy and INtravascular Ultrasound Imaging (SCAN)
Edward Pavillard
Pennsylvania Vascular Institute
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7149-3269
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 2
Posted 09 Jan, 2020
No community comments so far
Review #1 received
Received 29 Jan, 2020
Reviewer #1 agreed
On 08 Jan, 2020
Reviewers invited
Invitations sent on 08 Jan, 2020
Editor assigned
On 06 Jan, 2020
Submission checks complete
On 05 Jan, 2020
Editor invited
On 05 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 18 Dec, 2019
Reviewer #3 agreed
On 02 Dec, 2019
Review #1 received
Received 27 Oct, 2019
Review #2 received
Received 27 Oct, 2019
Reviewer #2 agreed
On 14 Oct, 2019
Reviewer #1 agreed
On 10 Oct, 2019
Reviewers invited
Invitations sent on 09 Oct, 2019
Editor assigned
On 30 Aug, 2019
Submission checks complete
On 29 Aug, 2019
Editor invited
On 29 Aug, 2019
First submitted
On 26 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Nuclear Medicine & Medical Imaging
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Intravascular imaging plays an important part in diagnosis of vascular conditions and providing insight for treatment strategy. Two main imaging modalities are intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The objective of this study was to prove non-inferiority of OCT imaging to IVUS images in matched segments of peripheral vessels in patients with suspected peripheral vascular disease. Methods: The SCAN study was a prospective, non-inferiority clinical study of matched IVUS and OCT images collected along defined segments of peripheral vessels from twelve subjects (mean age 68 10.3 years; 10 men) displaying symptoms of vascular disease. Luminal diameters were measured by both imaging systems at the distal, middle, and proximal points of the defined segments. Three blinded interventional radiologists evaluated the quality of both imaging modalities in identifying lMann-Whitney-Wilcoxon testing. Intrareader reproducibility was calculated by intraclass correlation (ICC) analysis. Results: The mean scoringof plaque, calcification, and vascular stent struts by the three readers was significant better in terms of image quality for OCT than IVUS (p<0.001, p=0.001, p=0.004, respectively). The mean scores of vessel wall component visibility and artifacts generated by the two imaging systems were not significantly different (p=0.19, p=0.07, respectively). Mean vessel luminal diameter and area at three specific locations within the vessels were not significantly different between the two imaging modalities. No patient injury, adverse effect or device malfunction were noted during thestudy. Conclusions: Imaging byOCT provides the physician with better visualization of some vessel and plaque chacteristics, but both IVUS and OCT imaging are safe and effective methods of examining peripheral vessels in order to perform diagnostic assessment of peripheral vessels and provide information necessary for the treatment strategy of peripheral artery disease.
Figure 1
Figure 2
Figure 3