Absorbable suture can be effectively and safely used to close the mesenteric defect in a gastric bypass Sprague-Dawley Rat Model
Background: To observe if absorbable suture can effectively and safely be used to close the mesenteric defect after Roux-en-Y reconstruction. Methods: Rats were randomly assigned to 5 experimental groups according to different suture materials used in closing the mesenteric defects (Peterson’s space) after Roux-en-Y gastric bypass. Group A (control group), Group B (non-absorbable suture, Prolene suture), Group C (biological glue), Group D (non-absorbable suture, polyester suture) and Group E (absorbable suture). All rats were followed up for 8 weeks postoperatively and underwent laparotomy to observe the degree of adhesion and closure of the mesenteric defect. Results: No significant difference was found in the decrease in food intake and body weight among all groups. No internal hernia (IH) occurred in any group. The mesenteric defects of Group A remained completely visible without any closure or adhesion. Multiple gaps were found between Prolene suture and the mesentery along the suture line in Group B. The mesenteric defects of Group C were complete closed with multiple adhesions of the small intestine and the greater omentum. The mesenteric defects had closed completely in both Group D and Group E. Average adhesion score of Group A and Group B was 0 and 0.33±0.52 respectively. Average adhesion score was higher in group C (3.83±0.41) than the other groups (p<0.05). Group D and E had similar average adhesion score, 3.17±0.41 and 3.00±0.00 respectively. Conclusion: Absorbable sutures can be effectively and safely used to close the mesenteric defect in a rat model.
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On 10 Jan, 2020
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Posted 04 Sep, 2019
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Received 15 Sep, 2019
On 07 Sep, 2019
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On 05 Sep, 2019
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On 05 Sep, 2019
On 29 Aug, 2019
On 29 Aug, 2019
On 23 Aug, 2019
Absorbable suture can be effectively and safely used to close the mesenteric defect in a gastric bypass Sprague-Dawley Rat Model
On 10 Jan, 2020
On 24 Dec, 2019
On 23 Dec, 2019
On 22 Dec, 2019
On 22 Dec, 2019
On 17 Dec, 2019
On 17 Dec, 2019
On 12 Dec, 2019
Received 24 Nov, 2019
Invitations sent on 15 Nov, 2019
On 15 Nov, 2019
On 22 Oct, 2019
On 21 Oct, 2019
On 21 Oct, 2019
On 20 Oct, 2019
On 11 Oct, 2019
On 11 Oct, 2019
Received 11 Oct, 2019
Invitations sent on 10 Oct, 2019
On 30 Sep, 2019
On 29 Sep, 2019
On 29 Sep, 2019
Posted 04 Sep, 2019
On 18 Sep, 2019
Received 17 Sep, 2019
Received 15 Sep, 2019
Received 15 Sep, 2019
On 07 Sep, 2019
Invitations sent on 05 Sep, 2019
On 05 Sep, 2019
On 05 Sep, 2019
On 05 Sep, 2019
On 29 Aug, 2019
On 29 Aug, 2019
On 23 Aug, 2019
Background: To observe if absorbable suture can effectively and safely be used to close the mesenteric defect after Roux-en-Y reconstruction. Methods: Rats were randomly assigned to 5 experimental groups according to different suture materials used in closing the mesenteric defects (Peterson’s space) after Roux-en-Y gastric bypass. Group A (control group), Group B (non-absorbable suture, Prolene suture), Group C (biological glue), Group D (non-absorbable suture, polyester suture) and Group E (absorbable suture). All rats were followed up for 8 weeks postoperatively and underwent laparotomy to observe the degree of adhesion and closure of the mesenteric defect. Results: No significant difference was found in the decrease in food intake and body weight among all groups. No internal hernia (IH) occurred in any group. The mesenteric defects of Group A remained completely visible without any closure or adhesion. Multiple gaps were found between Prolene suture and the mesentery along the suture line in Group B. The mesenteric defects of Group C were complete closed with multiple adhesions of the small intestine and the greater omentum. The mesenteric defects had closed completely in both Group D and Group E. Average adhesion score of Group A and Group B was 0 and 0.33±0.52 respectively. Average adhesion score was higher in group C (3.83±0.41) than the other groups (p<0.05). Group D and E had similar average adhesion score, 3.17±0.41 and 3.00±0.00 respectively. Conclusion: Absorbable sutures can be effectively and safely used to close the mesenteric defect in a rat model.
Figure 1
Figure 2
Figure 3
Figure 4