We herein elucidate the function of SARS-CoV-2 derived 5'UTR in the human cells. 5'UTR bound cellular RNA was immunoprecipitated by gRNA-dCas13 targeting luciferase RNA fused to SARS-CoV-2 5'UTR in HEK293T and A549 cells. The 5'UTR bound RNA extractions were predominantly enriched for regulating lipid metabolism. Overexpression of SARS-CoV-2 5'UTR RNA altered the expression of factors known to be involved in the process of the human Mevalonate pathway. Besides, HMMG-CoA reductase inhibitors suppressed 5'UTR-mediated translation activity, which is derived from the SARS-CoV-2 model. In conclusion, we deduce the array of host RNAs interacting with SARS-CoV-2 5'UTR that drives SARS-CoV-2 translational initiation and influences metabolic pathways.