As a new material, polyurethane polymer has been widely used in engineering in recent years due to the excellent engineering mechanical properties. Based on the characteristics of this material, a multi pipe grouting micro anti-slide pile is proposed, which is formed by using polymer slurry as grouting material. Compared with traditional anti-slide pile, the polymer micro pile has the advantages of strong applicability, no water reaction, small disturbance, fast construction, economy and durability. As a flexible retaining structure, polymer micro-piles can strengthen the slope by cooperating with the forces. However, there is no report on the reinforcement of slope by polymer micro piles at present. In this paper, a three-dimensional multi row polymer micro piles model for slope reinforcement considering different embedded depth and pile location is established. Safety factor, thrust force of landslide behind pile, length of pile and mises stress are taken as four factors to evaluate reinforcement effect, the optimal reliability of polymer micro anti-slide pile for slope reinforcement is evaluated by giving different weight values to each factor through multi factor comprehensive evaluation method. The safety factor of slope (Fs), landslide thrust behind pile and mises stress of pile are analyzed under different embedded depth (le) and pile position (px). The results show that the best embedded depth is about1/8 − 1/12 of the horizontal length of the landslide behind the pile when multi row polymer micro piles are used to reinforce the slope; the optimum position of pile arrangement is 0.55–0.65 times the slope length from the top of the slope.