A 12-year-old boy with history of chronic renal failure and recurrent hemodialysis, admitted with fever and chills from 7 days and rashes from 3 days prior to admission which disappeared before admission. Also, the patient complained of diarrhea, weakness, and fatigue without respiratory complaints. He had a history of COVID-19 in family members. He was toxic at admission and physical examination revealed the following: body temperature, 39.5 °C; pulse, 120 beats/min; blood pressure, 70/50 mmHg; and oxygen saturation, 92% in the ambient room. Although he didn’t have tachypnea or abnormal lung sounds, respiratory distress developed hours later. Vasoactive drugs, oseltamivir, meropenem, vancomycin, hydroxychloroquine, and Kaletra were prescribed. In the chest computed tomography (CT) scan, patchy ground-glass opacity and interlobar septal thickening were found compatible with COVID-19. In the complete blood count (CBC), lymphopenia, anemia, and thrombocytopenia were observed. Raised blood urea and creatinine, increased liver transaminases, proteinuria, hematuria, and marked acidosis in the arterial blood gas (ABG) were also noted, but creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and electrolytes were in normal values. The patient’s general condition deteriorated and he underwent tracheal intubation. Echocardiography showed mild mitral and tricuspid regurgitation, mild diastolic dysfunction, decreased left ventricular ejection fraction on the first day which deteriorated on the second day (Table 1). Packed red blood cell (packed cell), intravenous immunoglobulin (IVIG), and hydrocortisone prescribed. Before completion of the IVIG infusion, the patient’s condition deteriorated and he died on the third day after hospitalization. The result of COVID-19 RT-PCR was positive for him.
A 5-year-old girl presented with a history of 3 days high-grade fever (39-40 oc), vomiting of one episode and skin rash during fever, loss of appetite, intermittent cough, otalgia, and diarrhea. On admission, she was ill and irritable without respiratory distress and SPO2 was 99% in room air. She had bilateral otitis media and bilateral non-purulent conjunctivitis. Her parents had a suspicious history of COVID infection, so the chest CT-scan was performed and was normal. Treatment with ceftriaxone and zinc gluconate was started. Gradually, presentation of the disease changed and periorbital edema (day 3), headache, limb pain, pharyngeal congestion with punctuated exudate and purulent conjunctivitis appeared. Due to abdominal pain and tenderness, abdomino-pelvic ultrasonography was performed which was normal, except for mild to moderate free fluid was seen and also, mild to moderate bilateral pleural effusion was detected. Liver transaminases, serum amylase and lipase were in a normal range. Because of a family history of COVID-19 infection and new changes in the second chest CT-scan compatible with COVID-19 infection, hydroxychloroquine and azithromycin were started on the 3rd day and the patient was isolated. On day 5, COVID-19 RT-PCR result was positive, she was still febrile and her condition deteriorated. She became drowsy, tachypneic (respiratory rate: 38 /min) without retraction and dry cough and generalized edema developed. She became hypoxemic in room air with SpO2 of 88% and was subsequently transferred to the pediatric intensive care unit (PICU). On CBC, severe anemia and thrombocytopenia in addition to hypoalbuminemia were noted (table 1). So, packed red blood cells (packed cell), 1 g/kg IVIG and albumin were transfused and antibiotics changed to meropenem. Blood urea, Cr, LDH, peripheral blood smear, prothrombin time (PT), partial thromboplastin time (PTT), bilirubin, triglyceride, and fibrinogen level were in the normal range and urine analysis was normal. Blood and urine cultures did not yield any organism. Echocardiography showed mild tricuspid regurgitation, trivial mitral regurgitation with normal coronary arteries. During the first 8 days, fever subsided, but the patient was still tachypneic. Finally, the patient was discharged after 13 days with a good general condition
He was a 13-month-old boy presented with 4 days history of fever and 3 days of rash prior to admission. Skin rash started from the palms of the hands and the soles of the feet and then, erythematous patches, papule, and some target shape lesions on the edematous base on the trunk, limbs and face developed without itching sensation. He also defecated loose stool 2 to 3 times and had a loss of appetite and irritability without any respiratory signs except left tympanic membrane erythema. His parents worked in a COVID-19 referral ward. On admission day, chest CT-scan was normal and he was treated with hydroxychloroquine and ceftriaxone. On day 3, the patient’s condition deteriorated and generalized edema in addition to purulent conjunctivitis, intercostal and subcostal retraction, and respiratory distress with tachypnea appeared. While SPO2 was 84% in the ambient room, the second chest CT-scan changed to typical COVID-19 findings (bilateral pleural effusion, basilar patchy infiltration, and reverse halo sign). Anemia and hypoalbuminemia occurred while both of them were in the normal range on the admission day (Table 1). So, the patient was transferred to the PICU, and oxygen was administered with a hood and packed cell, albumin and IVIG (1 gr/kg) were transfused. Antibiotic was changed to meropenem and vancomycin. Abdominopelvic ultrasonography was normal except mild fluid observed in sub-hepatic, peri-splenic, and interloop space. Echocardiography showed mild tricuspid and mitral regurgitation and normal coronary arteries on two occasions. The patient gradually improved, skin rashes got better, he became afebrile and without any distress. He has discharged after 8 days and COVID-19 RT-PCR result was positive for him.
A 10-year-old girl presented with fever and itching skin rash from 5 days prior to admission. One day before admission, her general condition worsened; she got toxic and cough, abdominal pain, generalized edema and oliguria developed. The maculopapular and target shape skin rashes appeared with more accumulation around the neck, trunk, and axillary. Mucous membranes were intact except for bilateral conjunctivitis and cracked lips. She had a history of COVID-19 in family members. Physical examination at admission revealed the following: body temperature, 39.4 °C; pulse, 120 beats/min; respiration, 36 breaths/min; blood pressure, 66/40 mmHg; and oxygen saturation, 90%. Laboratory evaluation revealed anemia, hypoalbuminemia, and impaired renal function tests (Table 1). According to hypotension and shock, vasoactive drugs in addition to meropenem, clindamycin, vancomycin, IVIG, packed cell, and albumin prescribed (Table 1). The hemodynamic status of the patient stabilized after 3 days. Liver transaminases, PT, PTT, CPK, troponin, LDH, fibrin degradation products (FDP), C3, C4, and total hemolytic complement (CH50) were in a normal range. Antistreptolysin O, antiphospholipid antibody, and antinuclear antibody (ANA) were negative too. Blood and urine culture were also negative. Chest roentgenogram (CXR) and CT-scan were normal on the first admission day. COVID-19 RT-PCR test result was negative but COVID-19 immunoglobulin G (IgG) test was positive 7 days following admission. On day 3, edema, severe pain of right lower extremity, and venous stasis appeared due to central venous catheter insertion in the right femoral vein. Color Doppler ultrasonography of lower limb veins was normal. Enoxaparin was started as prophylaxis of deep vein thrombosis (DVT). Chest CT-scan on the fourth day showed COVID-19 compatible changes with mild bilateral pleural effusion. The urinary system was normal in ultrasonography. Echocardiography was performed for three times and showed mild tricuspid regurgitation, mild mitral regurgitation, mild pulmonary insufficiency, with normal ejection fraction and coronary arteries. Fever eased 4 days after admission, vitamin D, and zinc gluconate were added to the patient’s drugs. The general condition improved and vasoactive drugs tapered gradually. After 11 days, the patient was discharged with complete improvement.
He was a 14-month-old boy with a history of COVID-19 in family members, presented with fever and irritability from 5 days and skin rash from 3 days prior to admission. Maculopapular erythematous rashes presented from the trunk and upper limb. Then, generalized and hands and feet edema developed. Cracked lips, erythematous lips and tongue, and bilateral non-purulent conjunctivitis also appeared. During the first admission day, the patient became toxic and was transferred to the PICU. The CBC showed leukocytosis with a significant neutrophil count. Elevated ESR, CRP, and liver transaminases and were also found in addition to hypoalbuminemia. Urine analysis and CXR were normal. COVID-19 RT-PCR test was negative and chest CT-scan showed non-significant changes. So, cefotaxime, hydroxychloroquine, 2 gr/kg IVIG and 60 mg/kg aspirin, zinc, vitamin D, and albumin started. Echocardiography showed normal coronary arteries, mild right pleural effusion (5 mm), mild mitral regurgitation with a normal coronary artery on the first admission day. Because of prolonged Prothrombin Time (PT) and the partial thromboplastin time (PTT), fresh frozen plasma (FFP) and vitamin K were prescribed. Fever continued for 2 days after IVIG infusion and he was still toxic. So, the second dose of IVIG was infused on the fourth day of admission. Echocardiography showed diastolic dysfunction, mild right and left coronary artery dilatation in the left anterior descending artery (LAD) and the left circumflex artery without aneurysm. Liver transaminases, PT and PTT decreased to the normal value but leukocytosis continued and packed cell was transfused for severe anemia. Also, ceftriaxone changed to vancomycin and meropenem. The second chest CT-scan showed non-significant changes. While fever subsided on day 7, hydroxychloroquine discontinued but echocardiography showed progression in coronary arteries dilatation, moderate mitral and tricuspid regurgitation, decreased ejection fraction, and mild diastolic dysfunction. So, 2 mg/kg/day prednisolone, vasoactive drugs and furosemide started. On day 10, the patient became hemodynamically stable, so vasoactive drugs tapered but abdominal distension occurred with non-significant findings in the physical examination. Ultrasonography showed mild hepatosplenomegaly, intra-abdominal fluid, and bilateral pleural effusion. In CBC test result, leukocytosis and thrombocytosis (platelet count: 420.000/µL) were reported. Echocardiography showed progressive coronary artery aneurysm and beading and clopidogrel started. Abdominal distension improved during the last 5 days, and the skin rash disappeared with pilling on day 14. Still afebrile, he was toxic. COVID-19 RT-PCR result was negative but COVID-19 IgM was positive. After that, marked thrombocytosis appeared in the CBC (platelet count: 1.168.000/µL), ESR and CRP normalized but coronary artery dilatation progressed to a giant aneurysm in day 17 as follows: right coronary artery (RCA): 8.3 mm, left main coronary artery (LMCA) and LAD: 6.7-7.2 mm with good left ventricular ejection fraction. So, warfarin and infliximab were prescribed. The patient was discharged from the hospital with aspirin and warfarin. Results of other evaluations during admission like serum vitamin D, LDH, CPK, and antiphospholipid antibodies were unremarkable. Two weeks later, the coronary diameters decreased to 6 mm in RCA and near to 5 mm in LMCA and LAD in the follow-up echocardiography.
A 6.5-year-old boy with a history of COVID-19 in family members referred with fever from 3 days prior to admission, anorexia, and abdominal pain in the periumbilical and hypogastric area with occasional vomiting (3 times), one episode of loose defecation, and skin erythematous rash around ankles spreading to the trunk. He had no respiratory complaints and received a diclofenac and acetaminophen suppositories for fever and pain relief. He had a history of repaired duodenal atresia at birth. On physical exam, the patient was ill and febrile, had macular erythematous rashes around feet, hands, trunk and perioral, periorbital edema, erythema of oropharynx, right eardrum erythema and hypogastric tenderness. He had elevated ESR and CRP in addition to abnormal urine sediment. Ceftriaxone started and chest CT-scan were performed with non-significant changes for COVID-19. the urine culture of the first day yielded no organism. On the second day of admission, he got toxic and irritable with respiratory distress, low SPO2: 87%, mild abdominal distension, and anasarca edema. The patient was transferred to the PICU. Serum albumin was 2.6 g/dL, while other indexes like amylase and lipase were in normal values. So, albumin started. During the last 2 days, general condition of the patient got worst, he became anemic and more toxic, so albumin, 1 gr/kg IVIG, packed cell, hydroxychloroquine, and vitamin D were administered and ceftriaxone changed to vancomycin and meropenem. A second chest CT-scan showed bilateral opacity compatible with COVID-19. COVID-19 RT-PCR was negative but COVID-19 IgG was positive which was measured a week later. Abdominal ultrasonography showed mild splenomegaly, free interloop fluid, and several reactive lymph nodes. Echocardiography was performed two times and reported normal coronary arteries. Other investigations like Wright, Widal, blood, urine, and stool culture were negative. Transaminases, PT, PTT, LDH, FDP, and D-dimer were in normal values. The patient’s abdominal pain improved on day 6, and he was discharged after 11 days.
A 7.5-year-old girl presented with a history of fever, irritability, myalgia, vomiting, diarrhea, abdominal pain, generalized erythematous maculopapular and patches from 4 days prior to admission without respiratory complaints. Her parents were infected with COVID-19 nearly 2 weeks before admission. She received diclofenac and azithromycin before admission. On physical exam, she was ill with no distress. Erythema of the throat and generalized erythematous maculopapular and patches were observed. On the admission day, lymphopenia and vitamin D deficiency were noted (Table 1). Chest CT-scan, abdominal ultrasonography and stool exam were normal and cultures of the urine, blood, and stool were negative. So, ceftriaxone, hydroxychloroquine, zinc, and vitamin D prescribed. Evaluation for infection with COVID-19 with RT-PCR COVID-19 was negative. On the third admission day, facial edema, tachypnea and tachycardia developed and the patient got toxic with a gallop in heart auscultation. Due to marked hypoalbuminemia and anemia, packed cell and albumin were transfused. Blood urea and Cr raised, with normal values for serum electrolytes, PT, PTT, CPK, LDH, troponin, and liver transaminases. Anti-phospholipid antibodies were negative. Echocardiography showed low ejection fraction with dilated right and left ventricle, so, the diagnosis of myocarditis was raised; vasoactive drugs and 1 g/kg IVIG started and ceftriaxone changed to meropenem and vancomycin with magnesium sulphate for hypomagnesemia. CXR showed bilateral mild ground-glass opacity. Gradually, during last days, facial edema improved a little, but tachycardia and tachypnea were persistent on the 5th day. The second echocardiography report included mild pleural effusion, valve insufficiency, low ejection fraction, lack of tapering and brightness in RCA and LAD. So, another dose of IVIG (1 g/kg) with 60 mg/kg/day aspirin was prescribed. With the improvement in the hemodynamic status, vasoactive drugs gradually tapered. On the 7th day, the patient became afebrile and was discharged after 12 days with normal echocardiography and laboratory tests.
A 20-month-old boy with a history of COVID-19 in the family presented with intermittent fever from 7 days prior to admission. Gradually, coryza, vomiting, severe diarrhea, abdominal pain, irritability during urination, and loss of appetite appeared. He also had an erythematous papule with 2-centimeter diameter in the forehead and erythema of oropharynx. Before admission, he received metronidazole, cefixime, nalidixic acid, diclofenac, and acetaminophen without improvement. CBC at admission showed marked leukocytosis, thrombocytosis, anemia, and increased levels of ESR and CRP (Table 1). The stool exam had 4-5 white blood cells and 2-3 red blood cells. PT , PTT and blood levels of creatinine, urea, LDH, and CPK were in normal values. Urine analysis was unremarkable and cultures of blood, urine, and stool were negative. Abdominal ultrasonography was normal but Chest CT-scan showed bilateral ground-glass opacity compatible with COVID-19. So, the patient isolated and ceftriaxone, hydroxychloroquine, vitamin D, and zinc gluconate started. Hours after admission, he got tachypnea and SPO2 was 90% without supplementary oxygen. Unilateral tongue swelling and drooling with discrete ulcers under the tongue were seen. So, he was transferred to the PICU and ceftriaxone changed to clindamycin and meropenem. Echocardiography found a lack of tapering in RCA and LAD, mild dilatation of left atrium, and diastolic dysfunction. Before starting 2 g/kg IVIG and 80 mg/kg/day aspirin, fever subsided but he was still toxic. Seven days after admission, the patient’s condition improved and the second echocardiography after one week was normal. Results of COVID-19 RT-PCR, IgM, and IgG in the first week of admission were negative.
He was a 7-year-old boy with a fever from 3 days prior to admission. He also suffered from epigastric pain which was shifted to the right lower quadrant (RLQ) after 2 days and was not associated with eating. He had nausea, vomiting, and a normal defecation pattern. He was admitted 10 days ago for acute intravascular hemolysis due to glucose 6 phosphate dehydrogenase deficiency (G6PDd) and fava bean exposure and was treated with packed cell and hydration. During the recent admission, he was still ill and febrile without respiratory symptoms. On physical examination, tenderness in RLQ and rebound tenderness were noted. Ultrasonography showed reactive lymph nodes and free interloop fluid. In the CBC, leukocytosis with a shift to left was found. ESR and CRP were markedly elevated but urine and stool were unremarkable. So, the patient received ceftriaxone plus metronidazole and underwent appendectomy, but normal appendix with some exudative secretion in the peritoneal cavity was seen during the operation. After surgery, the patient's condition worsened and became toxic, developed abdominal distension and recurrent vomiting occurred. Abdominal X-ray was normal and repeated ultrasonography reported mild interloop fluid only. Chest CT-scan showed findings compatible with COVID-19 infection. Ceftriaxone changed to meropenem and vitamin D, hydroxychloroquine, and zinc gluconate started. Three days following admission, his fever subsided and abdominal complaints improved. Other investigations like liver transaminases, serum LDH and echocardiography were normal. After 4 days, the patient was discharged. Results of COVID-19 IgM, IgG and RT-PCR during hospitalization were negative.
An 18-month-old girl referred for a prolonged febrile seizure. The fever started from 4 days prior to admission and seizure was generalized tonic colonic accompanied with loss of consciousness, upward gaze, and foaming, which lasted for 40 minutes and was controlled with diazepam and phenobarbital in another hospital. The family was passenger from another province of Iran. She had an epileptic sister. On physical exam, she was lethargic and febrile without abnormal findings. She had lymphopenia and decreased serum albumin. Cerebrospinal fluid (CSF) analysis and electrolytes were normal and CSF, blood, and urine culture yielded no organism. Meropenem, clindamycin, phenobarbital, hydroxychloroquine, and vitamin D were prescribed. Brain CT-scan and CXR had no pathologic finding and chest CT-scan showed bilateral nonspecific opacity in inferior lobes. She was ill and lethargic during the first two days. So, albumin, 1 g/kg/day IVIG, and zinc gluconate were prescribed. On the third admission day, fever continued and maculopapular rashes appeared in the trunk. So, phenobarbital discontinued and echocardiography was performed which was normal. On this day, tachypnea developed, ABG was normal and second chest CT-scan on the 4th day had the same features of the first. COVID-19 RT-PCR result was positive. On the 5th admission day, fever subsided. Tachypnea improved within 4 days. After 3 days, the patient was discharged with good general condition.