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Research article
Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
Quan Liao
Peking Union Medical College Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1324-6213
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Surgery.
Background: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood.
Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups.
Results: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups.
Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.
Keywords
Distal pancreatectomy, Splenectomy, Spleen preservation, Leukocyte, Platelet
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
- Additionalfile1.jpg
Additional file 1. Flowchart showing patient enrolment in the present study. DP, distal pancreatectomy; DPS, distal pancreatectomy with splenectomy; SPDP, spleen-preserving distal pancreatectomy.
- Additionalfile2.tif
Additional file 2. Longitudinal changes in peripheral blood cell populations in the WT group vs. SVP group. (a) WBC, (b) neutrophil, (c) monocyte, (d) lymphocyte, (e) eosinophil, (f) basophil, (g) platelet, (h) RBC, (i) hemoglobin.
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Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 14 Oct, 2020
Published
On 31 Oct, 2020
No community comments so far
Editorial decision: Accept
On 23 Oct, 2020
Review #2 received
Received 13 Oct, 2020
Reviewer #2 agreed
On 12 Oct, 2020
Reviewer #1 agreed
On 30 Sep, 2020
Review #1 received
Received 30 Sep, 2020
Editor assigned
On 29 Sep, 2020
Reviewers invited
Invitations sent on 29 Sep, 2020
Submission checks complete
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Review #1 received
Received 17 Aug, 2020
Reviewer #1 agreed
On 16 Aug, 2020
Reviewer #2 agreed
On 16 Aug, 2020
Reviewers invited
Invitations sent on 10 Aug, 2020
First submitted
On 30 Jul, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Surgery
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This preprint is under consideration at BMC Surgery. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
Quan Liao
Peking Union Medical College Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1324-6213
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 14 Oct, 2020
Published
On 31 Oct, 2020
No community comments so far
Editorial decision: Accept
On 23 Oct, 2020
Review #2 received
Received 13 Oct, 2020
Reviewer #2 agreed
On 12 Oct, 2020
Reviewer #1 agreed
On 30 Sep, 2020
Review #1 received
Received 30 Sep, 2020
Editor assigned
On 29 Sep, 2020
Reviewers invited
Invitations sent on 29 Sep, 2020
Submission checks complete
On 28 Sep, 2020
Editor invited
On 28 Sep, 2020
No comments provided
Editorial decision: Minor revision
On 14 Sep, 2020
Review #2 received
Received 13 Sep, 2020
Review #1 received
Received 17 Aug, 2020
Reviewer #1 agreed
On 16 Aug, 2020
Reviewer #2 agreed
On 16 Aug, 2020
Reviewers invited
Invitations sent on 10 Aug, 2020
First submitted
On 30 Jul, 2020
Editor assigned
On 30 Jul, 2020
Submission checks complete
On 29 Jul, 2020
Editor invited
On 29 Jul, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
General Surgery
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Surgery.
Background: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood.
Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups.
Results: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups.
Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.
Figure 1
Figure 2