Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
Background: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood.
Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups.
Results: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups.
Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.
Figure 1
Figure 2
This is a list of supplementary files associated with this preprint. Click to download.
Additional file 1. Flowchart showing patient enrolment in the present study. DP, distal pancreatectomy; DPS, distal pancreatectomy with splenectomy; SPDP, spleen-preserving distal pancreatectomy.
Additional file 2. Longitudinal changes in peripheral blood cell populations in the WT group vs. SVP group. (a) WBC, (b) neutrophil, (c) monocyte, (d) lymphocyte, (e) eosinophil, (f) basophil, (g) platelet, (h) RBC, (i) hemoglobin.
Posted 14 Oct, 2020
On 31 Oct, 2020
On 23 Oct, 2020
Received 13 Oct, 2020
On 12 Oct, 2020
On 30 Sep, 2020
Received 30 Sep, 2020
On 29 Sep, 2020
Invitations sent on 29 Sep, 2020
On 28 Sep, 2020
On 28 Sep, 2020
On 14 Sep, 2020
Received 13 Sep, 2020
Received 17 Aug, 2020
On 16 Aug, 2020
On 16 Aug, 2020
Invitations sent on 10 Aug, 2020
On 30 Jul, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 29 Jul, 2020
Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study
Posted 14 Oct, 2020
On 31 Oct, 2020
On 23 Oct, 2020
Received 13 Oct, 2020
On 12 Oct, 2020
On 30 Sep, 2020
Received 30 Sep, 2020
On 29 Sep, 2020
Invitations sent on 29 Sep, 2020
On 28 Sep, 2020
On 28 Sep, 2020
On 14 Sep, 2020
Received 13 Sep, 2020
Received 17 Aug, 2020
On 16 Aug, 2020
On 16 Aug, 2020
Invitations sent on 10 Aug, 2020
On 30 Jul, 2020
On 30 Jul, 2020
On 29 Jul, 2020
On 29 Jul, 2020
Background: The clinical outcomes of patients who received distal pancreatectomy with splenectomy (DPS) and spleen-preserving distal pancreatectomy (SPDP) have been generally investigated. However, postoperative hematological changes after distal pancreatectomy with or without splenectomy are poorly understood.
Methods: Information from patients undergoing distal pancreatectomy (DP) between January 2014 and June 2019 at a single institution was reviewed. A linear mixed-effects model was used to compare dynamic hematological changes between different groups.
Results: A total of 302 patients who underwent DP were enrolled. In the long term, most postoperative hematological parameters remained significantly higher than preoperative levels in the DPS group, while postoperative lymphocyte, monocyte, basophil, and platelet levels returned to preoperative levels in the SPDP group. All postoperative hematological parameters except for red blood cell count and serum hemoglobulin level were significantly higher in the DPS group than in the SPDP group. There were no significant differences in hematological changes between the splenic vessel preservation (SVP) and Warshaw technique (WT) groups.
Conclusions: Postoperative hematological changes were significantly different between the DPS and SPDP groups. Compared to DPS, SPDP reduced abnormal hematological changes caused by splenectomy. SVP and WT were comparable in terms of postoperative hematological changes.
Figure 1
Figure 2