General characteristics
This study included 8063 patients with an average age of (50.88±11.92) years old, body mass index (25.02±3.39) kg/m2, systolic blood pressure (130.54±18.85) mmHg, diastolic blood pressure (78.66±11.96) mmHg, pulse ( 77.54±11.31) times/min. Among them, 5478 cases were male, accounting for 67.94%, aged 20-79 years old, and 2585 cases were female, accounting for 32.06%, aged 20-79 years old. The body mass index, systolic blood pressure, diastolic blood pressure, and glucose of men were higher than women, the difference was statistically significant (P<0.0001), while the pulse rate of men was lower than that of women, the difference was statistically significant (P<0.0001). Among men, the proportion of smoking is 23.95% and the proportion of drinking is 64.8%, which is much higher than that of women. Male ALT, γ-GT, TBIL, TG, LDL-c, Urea, Cr, UA are all higher than females, the difference is statistically significant (P<0.0001), TC, HDL-C are lower than females (P<0.001 ), there was no statistical difference in ALP between the
Comparison of various indicators grouped by Hcy high and low
The age, body mass index, systolic blood pressure, and diastolic blood pressure of the high-Hcy group were higher than those of the low-Hcy group, the difference was statistically significant (P<0.05), and the proportion of men, smoking and drinking was higher than that of the low-Hcy group, and the difference was statistically significant Academic significance (P<0.05).
The results of blood lipids showed that the TG of the high-Hcy group was significantly higher than that of the low-Hcy group, and the difference was statistically significant (P<0.05). The HDL-c of the high-Hcy group was significantly lower than that of the low-Hcy group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in TC and LDL-c between the high and low Hcy groups (P>0.05); the liver function results showed that the ALT, ALP, γ-GT and TBIL in the high-Hcy group were higher than those in the low-Hcy group, and the difference was statistically significant (P<0.05); Renal function results showed that Urea, Cr and UA in the high-Hcy group were significantly higher than those in the low-Hcy group, and the difference was statistically significant (P<0.05). See Table 2 for details.
Comparison of high and low Hcy indicators by gender
Among men, the age, systolic blood pressure, and diastolic blood pressure of the high-Hcy group were higher than those of the low-Hcy group, and the difference was statistically significant (P<0.05). The GLU between the high-Hcy group was lower than that of the low-Hcy group, and the difference was statistically significant (P<0.05); the γ-GT and TBIL of the high-Hcy group were higher than those of the low-Hcy group, and the difference was statistically significant (P<0.05); the TG of the high-Hcy group was significantly higher than that of the low-Hcy group, and the difference was statistically significant (P<0.05). The Cr and UA of the high-Hcy group were higher than those of the low-Hcy group, and the difference was statistically significant (P<0.05).
Among women, the age, BMI, systolic blood pressure and diastolic blood pressure of the high-Hcy group were significantly higher than those of the low-Hcy group, and the difference was statistically significant (P<0.05). The ALP of the high-Hcy group was higher than that of the low-Hcy group, and the difference was statistically significant (P<0.05). The TG of the high-Hcy group was significantly higher than that of the low-Hcy group, and the difference was statistically significant (P<0.05), while the HDL-C was lower than the low-Hcy group, and the difference was statistically significant (P<0.05); Both Cr and UA were significantly higher than the low-Hcy group, and the difference was statistically significant (P<0.05). See Table 3 for details.
Linear regression model analysis of the effect of serum Hcy level on blood lipid level
As shown in Table 3, the single factor linear regression model analysis results show that lnHcy is negatively correlated with lnHDL-c, and lnHcy is positively correlated with lnTG, lnALT, lnALP, lnγ-GT, lnTBIL, lnUrea, lnCr, and lnUA. The adjusted multivariate linear regression model analysis of gender, age, BMI, smoking and drinking showed that lnTG was positively correlated with lnHcy (β=0.080, SE=0.021, P<0.05), and lnHDL-c was negatively correlated with lnHcy (β= -0.021, SE=0.008, P<0.05), lnALT was negatively correlated with lnHcy (β=-0.053, SE=0.018, P<0.05), and lnTBIL was positively correlated with lnHcy (β=0.054, SE=0.014, P<0.05) ), lnCr was positively correlated with lnHcy (β=0.065, SE=0.006, P<0.05), and lnUA was positively correlated with lnHcy (β=0.069, SE=0.009, P<0.05). For the abnormal Hcy group (Hcy>15μmol/L), in univariate analysis, lnTC was negatively correlated with lnHcy (β=-0.032, SE=0.016, P<0.05), and lnHDL-c was negatively correlated with lnHcy (β=- 0.060, SE=0.017, P<0.05), lnALP is positively correlated with lnHcy (β=0.062, SE=0.022, P<0.05), and lnUrea is negatively correlated with lnHcy (β=-0.045, SE=0.021, P<0.05) , LnCr was positively correlated with lnHcy (β=0.065, SE=0.016, P<0.05), and lnUA was positively correlated with lnHcy (β=0.062, SE=0.020, P<0.05). In multivariate analysis, lnTC was negatively correlated with lnHcy (β=-0.036, SE=0.016, P<0.05), lnHDL-C was negatively correlated with lnHcy (β=-0.038, SE=0.016, P<0.05), lnALP It is positively correlated with lnHcy (β=0.068, SE=0.022, P<0.05), lnUrea is negatively correlated with lnHcy (β=-0.054, SE=0.027, P<0.05), and lnCr is positively correlated with lnHcy (β=0.055, SE =0.016, P<0.05), lnUA and lnHcy were positively correlated (β=0.043, SE=0.019, P<0.05). See Table 4 for details.
Logistic regression model analysis of serum Hcy on each index
The single factor logistic regression model showed that high lnHcy is the occurrence of high TG (OR: 1.870, 95% CI: 1.581-2.212, P<0.05), low HDL-C (OR: 1.803, 95% CI: 1.404-2.316, P< 0.05), abnormal γ-GT (OR: 1.270, 95%CI: 1.028-1.569, P<0.05), high TBIL (OR: 2.456, 95%CI: 1.741-3.464, P<0.05), high UA (OR: 3.106, 95%CI: 2.439-3.956, P<0.05) risk factors. High lnHcy is a protective factor for abnormal ALP (OR: 0.692, 95%CI: 0.531-0.900, P<0.05) and abnormal Cr (OR: 0.737, 95%CI: 0.565-0.960, P<0.05); multivariate logistic regression Model analysis results show that high lnHcy is high TG (OR: 1.281, 95%CI: 1.078-1.523, P<0.05), high UA (OR: 2.008, 95%CI: 1.565-2.575, P<0.05), abnormal TBIL (OR: 1.707, 95% CI: 1.205-2.418, P<0.05) risk factors. High lnHcy is a protective factor for abnormal Cr (OR: 0.663, 95% CI: 0.508-0.866, P<0.05) and high LDL-c (OR: 0.820, 95% CI: 0.699-0.962, P<0.05). For the abnormal Hcy group (Hcy>15μmol/L), single-factor logistic regression showed that high lnHcy is low HDL-C (OR: 1.772, 95% CI: 1.184-2.653, P<0.05), abnormal ALP (OR: 1.940, 95%CI: 1.093-3.444, P<0.05), high UA (OR: 1.485, 95%CI: 1.052-2.096, P<0.05), abnormal Cr (OR: 2.086, 95%CI: 1.271-3.366, P< 0.05) risk factors; multivariate logistic regression analysis results show that high lnHcy is low HDL-C (OR: 1.558, 95% CI: 1.017-2.386, P<0.05), abnormal ALP (OR: 1.992, 95% CI : 1.111-3.571, P<0.05), high UA (OR: 1.487, 95%CI: 1.037-2.131, P<0.05), abnormal Cr (OR: 2.241, 95%CI: 1.364-3.681, P<0.05) Risk factors. See Table 5 for details.