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Risk Factors for Brain Metastases in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis of 43 Studies
Xiaoli Zhu
Southeast University
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Lung cancer is a leading cause of cancer-related mortality worldwide. The purpose of our meta-analysis was to assess the risk factors for brain metastases in patients with non-small cell lung cancer.
Methods: Multiple databases, including PubMed, EMBASE, Cochrane Library, CNKI and Wanfang were systematically searched, then the meta-analysis was performed with RevMan 5.3 software and carried out evidence quality evaluation according to the GRADE standard. The estimated odds ratio and 95% confidence intervals were set as effect measures. Moreover, funnel plots and sensitivity analysis were used to assess the publication bias and reliability of the articles, respectively.
Results: A total of 43 studies with 11415 participants were eligible. The results indicated that female, adenocarcinoma or non-squamous cell carcinoma, advanced tumor stage, node stage, 1ymphatic metastasis, epidermal growth factor receptor gene mutation, kirsten rat sarcoma viral oncogene gene mutation, and higher levels of carcinoembryonic antigen, carbohydrate antigen 199, cytokeratin-19 fragment, neuron-specific enolase and carbohydrate antigen 125 were significantly associated with an increased risk of brain metastases (P<0.05) in non-small cell lung cancer patients. Moreover, the non-small cell lung cancer with brain metastases group had a significantly lower survival rate than the non-small cell lung cancer group (P<0.05).
Conclusions: The meta-analysis demonstrated that non-small cell lung cancer patients with brain metastases have more aggressive clinical features and poor survival prognosis.
Keywords
Non-small cell lung cancer, brain metastases, risk factors, meta-analysis, prognosis
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This is a preprint. It has not completed peer review.
Research
Risk Factors for Brain Metastases in Patients with Non-Small Cell Lung Cancer: A Meta-Analysis of 43 Studies
Xiaoli Zhu
Southeast University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Oncology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Lung cancer is a leading cause of cancer-related mortality worldwide. The purpose of our meta-analysis was to assess the risk factors for brain metastases in patients with non-small cell lung cancer.
Methods: Multiple databases, including PubMed, EMBASE, Cochrane Library, CNKI and Wanfang were systematically searched, then the meta-analysis was performed with RevMan 5.3 software and carried out evidence quality evaluation according to the GRADE standard. The estimated odds ratio and 95% confidence intervals were set as effect measures. Moreover, funnel plots and sensitivity analysis were used to assess the publication bias and reliability of the articles, respectively.
Results: A total of 43 studies with 11415 participants were eligible. The results indicated that female, adenocarcinoma or non-squamous cell carcinoma, advanced tumor stage, node stage, 1ymphatic metastasis, epidermal growth factor receptor gene mutation, kirsten rat sarcoma viral oncogene gene mutation, and higher levels of carcinoembryonic antigen, carbohydrate antigen 199, cytokeratin-19 fragment, neuron-specific enolase and carbohydrate antigen 125 were significantly associated with an increased risk of brain metastases (P<0.05) in non-small cell lung cancer patients. Moreover, the non-small cell lung cancer with brain metastases group had a significantly lower survival rate than the non-small cell lung cancer group (P<0.05).
Conclusions: The meta-analysis demonstrated that non-small cell lung cancer patients with brain metastases have more aggressive clinical features and poor survival prognosis.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9