Brother-Sister (B-S) kinship analysis by autosomal STRs.
To examine the kinship analysis between brother and sister analysis using autosomal STR markers, sensitivity and 1-specificity values at different allele matching scores were calculated. Independent t-Test showing a statistically significant difference between B-S (related) and non-B-S (unrelated) group based on OAM and TAM score were calculated. The average TAM score for the B-S group is 3.92 ± 1.754 (SD), and for the non-B-S group average, TAM is 0.80 ± 0.764 (SD). Whereas the average OAM score for the B-S group is 8.64 ± 1.846 and for the non-B-S group is 7.48 ± 1.531 (Fig. 1). Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve were shown in Table 1. The smallest OAM cutoff score value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum perceived test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values (Table 1).
Table 1
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve)
Test Result Variable(s): One Allele Match Score
|
OAM scores
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
3.00
|
1.000
|
1.000
|
4.50
|
1.000
|
0.960
|
5.50
|
1.000
|
0.880
|
6.50
|
0.800
|
0.800
|
7.50
|
0.720
|
0.480
|
8.50
|
0.520
|
0.280
|
9.50
|
0.400
|
0.080
|
10.50
|
0.160
|
0.000
|
11.50
|
0.040
|
0.000
|
13.00
|
0.000
|
0.000
|
The sensitivity and specificity of the test with AMCOS of 9 were found to be 52% and 72 %, respectively. The predictive values for positive and negative predictions were found to be 65% and 60%, respectively, and the overall accuracy of the test was found to be 62% (Table 2).
Table 2
Evaluation of AMCOS (OAM) in AMCOS in brother-sister kinship analysis by autosomal STR analysis:
Statistic
|
Value
|
95% CI
|
Sensitivity
|
52.00%
|
31.31–72.20%
|
Specificity
|
72.00 %
|
50.61–87.93%
|
Positive Predictive Value
|
65.00%
|
47.16–79.44%
|
Negative Predictive Value
|
60.00 %
|
48.25–70.70%
|
Accuracy
|
62.00%
|
47.17–75.35%
|
Analysis of TAM scores in Brother - Sister (B-S) identification.
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve) were given in Table 3. The smallest TAM cutoff score value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum perceived test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values (Table 3).
Table 3
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve)
TAM scores
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
-1.00
|
1.000
|
1.000
|
0.50
|
0.960
|
0.600
|
1.50
|
0.960
|
0.200
|
2.50
|
0.920
|
0.000
|
3.50
|
0.520
|
0.000
|
4.50
|
0.320
|
0.000
|
5.50
|
0.120
|
0.000
|
7.00
|
0.080
|
0.000
|
9.00
|
0.000
|
0.000
|
The sensitivity and specificity of the test with AMCOS of 3 were found to be 92% and 100 %, respectively. The predictive values for positive and negative predictions were found to be 100% and 93%, respectively, and the overall accuracy of the test was found to be 96% (Table 4).
Table 4
Evaluation of AMCOS in AMCOS (TAM) in brother-sister kinship analysis by autosomal STR markers.
Statistic
|
Value
|
95% CI
|
Sensitivity
|
92.00%
|
73.97–99.02%
|
Specificity
|
100.00 %
|
86.28–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
92.59 %
|
76.79–97.93%
|
Accuracy
|
96.00%
|
86.29–99.51%
|
Brother-sister (B-S) kinship analysis by X-STRs.
Independent t-Test showing a statistically significant difference between B-S (related) and non-B-S (unrelated) groups based on the OAM score were analyzed. Average OAM score for B-S group is 7.88 ± 2.075 (SD), whereas for the non-B-S group is 4.24 ± 1.363 (SD). ROC curve to assess the accuracy of the test in discriminating the true cases (B-S) from the false (Non-B-S) cases are shown in Fig. 2. The smallest OAM cutoff value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values (Table 5)
Table 5
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve)
Test Result Variable(s): One allele (maternal) matching (OAM) score /12
|
OAM score
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
1.00
|
1.000
|
1.000
|
2.50
|
1.000
|
0.880
|
3.50
|
0.880
|
0.760
|
4.50
|
0.840
|
0.320
|
5.50
|
0.800
|
0.240
|
6.50
|
0.680
|
0.040
|
7.50
|
0.560
|
0.000
|
8.50
|
0.520
|
0.000
|
9.50
|
0.360
|
0.000
|
10.50
|
0.160
|
0.000
|
11.50
|
0.080
|
0.000
|
13.00
|
0.000
|
0.000
|
The sensitivity and specificity of the test with AMCOS of 6, when applied to the B-S sibling group, was found to be 80% and 76 %, respectively. The predictive values for positive and negative predictions were found to be 77% and 79%, respectively, and the overall accuracy of the test was found to be 78% (Table 6).
Table 6
Evaluation of AMCOS in brother-sister kinship identification by X-STR markers
Statistic
|
Value
|
95% CI
|
Sensitivity
|
80.00%
|
59.30–93.17%
|
Specificity
|
76.00 %
|
54.87–90.64%
|
Positive Predictive Value
|
76.92%
|
61.76–87.31%
|
Negative Predictive Value
|
79.17 %
|
62.73–89.56%
|
Accuracy
|
78.00%
|
64.04–88.47%
|
Brother-Brother (B-B) Kinship analysis by autosomal STRs:
Independent t-Test showing a statistically significant difference between B-B (related) and non-B-B (unrelated) group based on the TAM score were analyzed. The average TAM score for B-B is 4.85 ± 1.496 (SD), whereas, for the non-B-B group, the average TAM is 0.60 ± 0.681 (SD). Only two allele matching (TAM) scores showed a significant difference between the two (related and unrelated) groups (Fig. 3). So only the TAM score was evaluated for its efficiency as a biomarker for brother-brother kinship analysis by autosomal STR markers. Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve were calculated (Table 7). The smallest TAM score cutoff value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum perceived test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
Table 7
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve)
Test Result Variable(s): Two Allele Match Score
|
TAM scores
|
Sensitivity
Y-axis coordinates
|
1 – Specificity
X-axis coordinates
|
-1.00
|
1.000
|
1.000
|
0.50
|
1.000
|
0.500
|
1.50
|
1.000
|
0.100
|
2.50
|
0.950
|
0.000
|
3.50
|
0.800
|
0.000
|
4.50
|
0.600
|
0.000
|
5.50
|
0.350
|
0.000
|
6.50
|
0.100
|
0.000
|
7.50
|
0.050
|
0.000
|
9.00
|
0.000
|
0.000
|
The sensitivity and specificity of the test with AMCOS of 3 were found to be 95% and 100 %, respectively. The predictive values for positive and negative predictions were found to be 100% and 95%, respectively, and the overall accuracy of the test was found to be 97.5% (Table 8).
Table 8
Evaluation of AMCOS in Brother-Brother identification by autosomal STR analysis.
Statistic
|
Value
|
95% CI
|
Sensitivity
|
95.00%
|
75.13–99.87%
|
Specificity
|
100.00 %
|
83.16–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
95.24 %
|
74.75–99.27%
|
Accuracy
|
97.50%
|
86.84–99.94%
|
Brother-Brother (B-B) Kinship analysis by X STR analysis:
Independent t-Test showing a statistically significant difference between B-B and non-B-B group based on the OAM score were analyzed using X-STRs. The Average OAM score for the B-B group is 9.1 ± 2.075 (SD), whereas for the non-B-B group average OAM score is 1.85 ± 0.040 (SD). ROC curve to assess the accuracy of the test in discriminating against the true sibling (Brother-Brother) cases from false cases is shown in Fig. 4. Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve) were shown in Table 9.
Table 9
Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve)
Test Result Variable(s): One Allele Match Score
|
OAM score
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
-1.00
|
1.000
|
1.000
|
0.50
|
1.000
|
0.950
|
1.50
|
1.000
|
0.600
|
2.50
|
1.000
|
0.200
|
3.50
|
1.000
|
0.100
|
4.50
|
1.000
|
0.000
|
5.50
|
0.950
|
0.000
|
6.50
|
0.900
|
0.000
|
7.50
|
0.800
|
0.000
|
8.50
|
0.550
|
0.000
|
9.50
|
0.450
|
0.000
|
10.50
|
0.250
|
0.000
|
11.50
|
0.200
|
0.000
|
13.00
|
0.000
|
0.000
|
The smallest OAM cutoff score value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum perceived test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 5 were found to be 100 %. The predictive values for positive and negative predictions were also found to be 100%, and the overall accuracy of the test was 100% too (Table 10).
Table 10
Evaluation of AMCOS in AMCOS in Brother-bother identification by X-STR analysis
Statistic
|
Value
|
95% CI
|
Sensitivity
|
100.00%
|
83.16–100.00%
|
Specificity
|
100.00%
|
83.16–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
100.00 %
|
-
|
Accuracy
|
100.00%
|
91.19%to 100.00%
|
Sister- Sister (S-S) kinship analysis by autosomal STRs:
Independent t-Test showing a statistically significant difference between S-S (related) and non-S-S (unrelated) groups based on the TAM score were calculated. The Average TAM score for S-S is 5.45 ± 1.63 (SD), whereas, for the non-S-S group, the average TAM is 0.95 ± 0.326 (SD). Only two allele matching (TAM) scores showed a significant difference between the two (related and unrelated) groups. So only the TAM score was evaluated for its efficiency as a biomarker for sister-sister kinship analysis by autosomal STR markers (Fig. 5). Sensitivity and 1-specificity values at different allele matching scores were calculated on the basis of the ROC curve are shown in Table 11.
Table 11
Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve)
Test Result Variable(s): Two Allele Match Score
|
TAM score a
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
-1.00
|
1.000
|
1.000
|
0.50
|
1.000
|
0.650
|
1.50
|
1.000
|
0.300
|
2.50
|
0.950
|
0.000
|
3.50
|
0.850
|
0.000
|
4.50
|
0.750
|
0.000
|
5.50
|
0.550
|
0.000
|
6.50
|
0.250
|
0.000
|
7.50
|
0.100
|
0.000
|
9.00
|
0.000
|
0.000
|
The smallest cutoff value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 3 were found to be 95% and 100 %, respectively. The predictive values for positive and negative predictions were found to be 100% and 95%, respectively, and the overall accuracy of the test was found to be 97.5% (Table 12).
Table 12
Evaluation of AMCOS in Sister-Sister identification by autosomal STR markers.
Statistic
|
Value
|
95% CI
|
Sensitivity
|
95.00%
|
75.13–99.87%
|
Specificity
|
100.00 %
|
83.16–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
95.24 %
|
74.75–99.27%
|
Accuracy
|
97.50%
|
86.84–99.94%
|
Sister- Sister (S-S) kinship analysis by X-STR analysis:
Independent t-Test showing a statistically significant difference between S-S (related) and non-S-S (unrelated) groups based on the OAM score were analyzed. The Average OAM score for S-S is 11.85 ± 0.366 (SD), whereas, for the non-S-S group, the average OAM is 5.90 ± 2.049 (SD). ROC curve and AUC to assess the accuracy of the test in discriminating the true cases (S-S cases) from the false cases (non-S-S cases) (Fig. 6). Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve are shown in Table 13.
Table 13
Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve).
Test Result Variable(s): One Allele Match Score
|
OAM score a
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
1.00
|
1.000
|
1.000
|
3.00
|
1.000
|
0.900
|
4.50
|
1.000
|
0.800
|
5.50
|
1.000
|
0.550
|
6.50
|
1.000
|
0.450
|
7.50
|
1.000
|
0.150
|
8.50
|
1.000
|
0.100
|
9.50
|
1.000
|
0.050
|
10.50
|
1.000
|
0.000
|
11.50
|
0.850
|
0.000
|
13.00
|
0.000
|
0.000
|
The smallest OAM cutoff score value is the minimum observed test value minus 1, and the most considerable cutoff value is the maximum perceived test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 11 were found to be 100%. The predictive values for positive and negative predictions were also found to be 100%, and the overall accuracy of the test was also 100% (Table 14).
Table 14
Evaluation of AMCOS in Sister-Sister identification by X-STR analysis.
Statistics
|
Value
|
95% CI
|
Sensitivity
|
100.00%
|
83.16–100.00%
|
Specificity
|
100.00 %
|
83.16–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
100.00 %
|
-
|
Accuracy
|
100.00%
|
91.19–100.00%
|
Grandparents –Grandchildren (GP-GC) by autosomal STR analysis:
Independent t-Test showing a statistically significant difference (Statistically significant difference (p < 0.05) between GP-GC (related) and non-GP-GC (unrelated) group based on the OAM score were analyzed. The Average OAM score for GP-GC is 11.54 ± 2.64 (SD), whereas, for the non-GP-GC group, the average OAM is 8.27 ± 2.146 (SD). The ROC curve and AUC to assess the accuracy of the test in discriminating the true cases (Grand parentage cases) from the false cases (non-Grand parentage cases) (Fig. 7). Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve were shown in Table 15.
Table 15
Sensitivity and 1-specificity values at different allele matching scores calculated based on the ROC curve (Coordinates of the curve):
Test Result Variable(s): OAM
|
OAM scoresa
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
3.00
|
1.000
|
1.000
|
4.50
|
1.000
|
0.962
|
5.50
|
1.000
|
0.923
|
6.50
|
0.962
|
0.769
|
7.50
|
0.962
|
0.615
|
8.50
|
0.923
|
0.462
|
9.50
|
0.852
|
0.350
|
10.50
|
0.654
|
0.154
|
11.50
|
0.577
|
0.038
|
12.50
|
0.385
|
0.038
|
13.50
|
0.192
|
0.000
|
15.00
|
0.000
|
0.000
|
a. The smallest cutoff value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 10 were found to be 85% and 65 %, respectively. The predictive values for positive and negative predictions were found to be 74% and 85%, respectively, and the overall accuracy of the test was found to be approx 79 % (Table 16).
Table 16
Evaluation of AMCOS in Grand-parentage identification by autosomal STR markers.
Statistic
|
Value
|
95% CI
|
Sensitivity
|
85.20%
|
69.85–97.55%
|
Specificity
|
65.00 %
|
48.21–85.67%
|
Positive Predictive Value
|
74.19%
|
61.37–83.88%
|
Negative Predictive Value
|
85.71 %
|
66.75–94.72%
|
Accuracy
|
78.85%
|
65.30–88.94%
|
Grandparents –Grandchildren (GP-GC) by X-STR analysis:
Grandparents –Grandchildren relationship are found in paternal and maternal side. Therefore in this study kinship analysis of GP-GC paternal side and maternal side studied as follows.
Part 1: Paternal grandparents.
Independent t-Test showing a statistically significant difference between paternal GP-GC (related) and non-GP-GC (unrelated) group based on the OAM score were examined. The average OAM score for GP-GC is 12 ± 0.00 (SD), whereas, for the non-GP-GC group, the average OAM is 6.57 ± 0.976 (SD). ROC curve and AUC to assess the accuracy of the test in discriminating the true cases (Grand parentage cases) from the false cases (non-Grand parentage cases) (Fig. 8). Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve) were shown in Table 17.
Table 17
Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve)
Test Result Variable(s): one allele matching score from PGM to Grand DAUGHTER
|
OAM scoresa
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
4.00
|
1.000
|
1.000
|
5.50
|
1.000
|
0.857
|
6.50
|
1.000
|
0.571
|
7.50
|
1.000
|
0.143
|
10.00
|
1.000
|
0.000
|
13.00
|
0.000
|
0.000
|
a. The smallest OAM cutoff score value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 10 were found to be 100 %. The predictive values for positive and negative predictions were found to be 100%, and the overall accuracy of the test was also found to be 100% (Table 18).
Table 18
Evaluation of AMCOS in paternal Grand-parentage determination by X-STR analysis.
Statistic
|
Value
|
95% CI
|
Sensitivity
|
100.00%
|
59.04–100.00%
|
Specificity
|
100.00 %
|
59.04–100.00%
|
Positive Predictive Value
|
100.00%
|
-
|
Negative Predictive Value
|
100.00 %
|
-
|
Accuracy
|
100.00%
|
76.84–100.00%
|
Part2: Maternal Grandparents.
Independent t-Test showing a statistically significant difference between maternal GP-GC (related) and non-GP-GC (unrelated) group based on the OAM score were analyzed. The average OAM score for GP-GC is 8.85 ± 2.794 (SD), whereas, for the non-GP-GC group, the average OAM is 3.15 ± 1.625 (SD). ROC curve and AUC to assess the accuracy of the test in discriminating the true cases (Grand parentage cases) from the false cases (non-Grand parentage cases) were shown in Fig. 9. Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve) were shown in Table 19.
Table 19
Sensitivity and 1-specificity values at different allele matching scores calculated on the basis of the ROC curve (Coordinates of the curve).
Test Result Variable(s): ONE ALLELE MATCHING SCORE /12
|
OAM score a
|
Sensitivity
(Y-axis coordinates)
|
1 – Specificity
(X-axis coordinates)
|
-1.00
|
1.000
|
1.000
|
0.50
|
1.000
|
0.923
|
1.50
|
1.000
|
0.846
|
2.50
|
1.000
|
0.769
|
3.50
|
1.000
|
0.308
|
4.50
|
0.846
|
0.231
|
5.50
|
0.846
|
0.077
|
6.50
|
0.769
|
0.000
|
8.00
|
0.692
|
0.000
|
9.50
|
0.462
|
0.000
|
10.50
|
0.385
|
0.000
|
11.50
|
0.154
|
0.000
|
13.00
|
0.000
|
0.000
|
a. The smallest OAM cutoff score value is the minimum observed test value minus 1, and the largest cutoff value is the maximum observed test value plus 1. All the other cutoff values are the averages of two consecutive ordered observed test values.
The sensitivity and specificity of the test with AMCOS of 6 were found to be 85% and 92%, respectively. The predictive values for positive and negative predictions were found to be 92% and 86%, respectively, and the overall accuracy of the test was found to be 88% (Table 20).
Table 20
Evaluation of AMCOS in maternal Grandparent – Grandchildren identification by X-STR markers
Statistic
|
Value
|
95% CI
|
Sensitivity
|
84.62%
|
54.55–98.08%
|
Specificity
|
92.31%
|
63.97–99.81%
|
Positive Predictive Value
|
91.67%
|
62.26–98.65%
|
Negative Predictive Value
|
85.71%
|
62.42–95.59%
|
Accuracy
|
88.46%
|
69.55–97.55%
|
Over all, above mentioned results were presented in the Table 21 and Table 22.
Table 21
AMCOS for autosomal and X-STR markers in various sorts of kinship case
Type of kinship
|
Allele Match cut off score (AMCOS)
|
Autosomal STR
|
X-STR
|
TAM
|
OAM
|
OAM
|
TAM
|
B-S
|
3
|
9
|
6
|
NA
|
B-B
|
3
|
NS
|
5
|
NA
|
S-S
|
3
|
NS
|
11
|
NS
|
GP-GC
|
NA
|
10
|
6 for MGP &
10 for PGP
|
NA
|
NA: Not applicable, NS: Non- significant.
MGP: Maternal Grandparents.
PGP: Paternal Grandparents.
Table 22: Comparison table for autosomal and X-STR markers with respect to the statistical parameters calculated for various kinship analyses.
PARAMETER
|
B-S
|
B-B
|
S-S
|
GP-GC
|
X
|
AUTO
|
X
|
AUTO
|
X
|
AUTO
|
X
|
AUTO
|
Maternal- GP
|
Paternal-GP
|
Sensitivity
|
80%
59.30% to 93.17%
(95% CI)
|
92%
73.97%
to
99.02% (95% CI)
|
100%
83.16% to 100%
(95%CI)
|
95%
75.13% to 99.87% (95% CI)
|
100%
83.16% to 100% (95% CI)
|
95%
75.13 % to 99.87% (95%CI)
|
84.62%
54.55%
to 98.08%
(95%CI)
|
100%
59.04% to
100% (95%CI)
|
85.20%
69.85% to 97.55% (95%CI)
|
Specificity
|
76%
54.87% to 90.64%
(95% CI)
|
100%
86.28%
to
100% (95% CI)
|
100%
83.16%
to
100% (95%CI)
|
100%
83.16% to
100% (95% CI)
|
100%
83.16% to 100% (95% CI)
|
100%
83.16 %
to
100% (95%CI)
|
92.31 %
63.97%
to
99.81%
(95%CI)
|
100%
59.04%
to
100% (95%CI)
|
65%
48.21% to 85.67% (95%CI)
|
PPV
|
76.92%
61.76% to 87.81% (95% CI)
|
100%
|
100%
|
100%
|
100%
|
100%
|
91.67%
62.26%
To
98.65%
(95%CI)
|
100%
|
74.19%
61.37% to 83.88% (95%CI)
|
NPV
|
79.17%
62.73% to 89.56% (95% CI)
|
92.59%
76.79% to 97.93% (95% CI)
|
100%
|
95.24%
74.75% to
99.27% (95% CI)
|
100%
|
95.24%
74%
to 99.27% (95%CI)
|
85.71 %
62.42%
To
95.59%
(95%CI)
|
100%
|
85.71%
66.75% to 94.72% (95%CI)
|
ACCURACY
|
78%
64.04% to 88.47%
(95% CI)
|
96%
86.29% to 99.51% (95% CI)
|
100%
91.19% to
100%
(95%CI)
|
97.50%
86.84% to 99.94% (95% CI)
|
100%
91.19% to 100% (95% CI)
|
97.50%
86.84% to 99.94% (95%CI)
|
88.46%
69.55%
To
97.55%
(95%CI)
|
100%
76.84%
to
100% (95%CI)
|
78.85%
65.30% to 88.94% (95%CI)
|