As COVID-19 run rampant in high-density housing sites, it is important to use real-time data tracking the virus mobility. Emerging cluster detection analysis is a precise way of blunting the spread of COVID-19 as quickly as possible and save lives. To track compliable mobility of COVID-19 on a spatial-temporal scale, this research is appropriately analyzed the disparities between spatial-temporal clusters, expectation Maximization clustering (EM) and hierarchical clustering (HC) analysis on Texas county-level. Then, based on the outcome of clustering analysis, the sensitive counties are Cottle, Stonewall, Bexar, Tarrant, Dallas, Harris, Jim hogg, and Real, corresponding to South-east Texas analysis in GWR modeling. The sensitive period took place in the last two quarters in 2020. We explored Postgre application to portray tracking Covid-19 trajectory. We captured 14 social, economic, and environmental 14 impact’s indices to perform Principal Component Analysis (PCA) to reduce dimensionality and minimize multicollinearity. By using the PCA, we extracted five factors related to mortality of COVID-19, involved population and hospitalization, age structure, natural supply, economic condition, air quality and medical care. We established the GWR model to seek the sensitive factors. The result shows that population, hospitalization, and economic condition are the sensitive factors. Those factors also triggered high increase of COVID-19 mortality. This research provides geographical understanding and solution of controlling COVID-19, reference of implementing geographically targeted ways to track virus mobility and satisfy for the need of Emergency Operations Plan (EOP).