The Municipality of Štrpce (Southern Serbia) is an area located within the Šar Mountain National Park, and due to its great ecological importance, it was necessary to analyze the terrain susceptibility to the occurrence of natural hazards. The main goal of this research is to determine the locations that are most susceptible to natural hazards (earthquakes, erosion, torrential flooding, snow avalanches and forest fires) on the territory of the municipality of Štrpce. By utilizing the geographic information systems (GIS), the first step was to analyze seismic hazard for a 475-year return period (VII-VIII MCS for the observed area). The second step was to determine the intensity of erosion and total sediment production using erosion potential model (EPM). The mean erosion coefficient is quantified to 0.34, and the total sediment production is 131.795 m3/year. The third step was the analysis potential of torrential floods using the Flash Flood Potential Index (FFPI). This method indicated that 43.33% of the municipality is highly susceptible, and 18.86% is very highly susceptible to torrential floods. The Avalanches Potential Index (AVAPI) method was used for the fourth step which involved determining the area prone to the occurrence and movement of avalanches. It was determined that 9.1 km2 of the municipality area is susceptible to this type of hazard. The fifth step included the analysis of the terrain susceptibility to the occurrence of forest fires. More than half of the municipal area (52.4%) is highly susceptible, and 8.5% is very highly susceptible to forest fires. Following the five criteria analysis, weight coefficients were assigned for each of the analyzed parameters using the analytical hierarchy process (AHP), giving the result of the total susceptibility of the territory of Štrpce to natural hazards. Results indicated that over 45% of the municipality is highly or very highly prone to various natural hazards. This paper presents a significant step towards better understanding and more adequate management and mitigation of natural hazards not only in the investigated area, but on regional and national levels as well.