See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Sang Sik Choi
Korea University Guro Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0260-9886
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Continuous epidural block is commonly used in clinical settings and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacies of conventional continuous epidural block and continuous epidural block involving electric stimulation-guided localization of the catheter to areas with neurological damage, in the treatment of herpes zoster pain and prevention of postherpetic neuralgia.
Methods We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: esopocan (conventional continuous epidural block) and epistim (continuous epidural block with epidural electric stimulation). In the esopocan group, the position of the epidural catheter was confirmed using contrast medium alone, whereas in the epistim group, the site of herpes zoster infection was identified through electric stimulation using the guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6 month follow-up period after each procedure.
Results After adjusting for confounding variables, the pain score was significantly lower in the epistim group than in the esopocan group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the epistim group than the esopocan group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the esopocan group than the epistim group (95% confidence interval: 1.17-11.19, P = 0.03).
Conclusion Epidural drug administration to specific spinal segments using electrical stimulation catheters may be more helpful than conventional continuous epidural block in improving pain and preventing postherpetic neuralgia in acute herpes zoster.
Keywords
herpes zoster, postherpetic neuralgia, epidural analgesia, continuous epidural block, electric stimulation
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
No community comments so far
Reviewer #1 agreed
On 16 Jan, 2020
Review #1 received
Received 16 Jan, 2020
Editor assigned
On 15 Jan, 2020
Reviewers invited
Invitations sent on 15 Jan, 2020
Submission checks complete
On 14 Jan, 2020
Editor invited
On 14 Jan, 2020
No comments provided
Reviewer #3 agreed
On 05 Jan, 2020
Review #3 received
Received 05 Jan, 2020
Editorial decision: Major revision
On 05 Jan, 2020
Review #2 received
Received 28 Nov, 2019
Reviewer #2 agreed
On 10 Nov, 2019
Review #1 received
Received 05 Nov, 2019
Editor assigned
On 21 Oct, 2019
Reviewers invited
Invitations sent on 21 Oct, 2019
Reviewer #1 agreed
On 21 Oct, 2019
Submission checks complete
On 20 Oct, 2019
Editor invited
On 20 Oct, 2019
Version 1
Posted 19 Sep, 2019
No comments provided
Editorial decision: Major revision
On 30 Sep, 2019
Reviewer #1 agreed
On 17 Sep, 2019
Review #1 received
Received 17 Sep, 2019
Review #2 received
Received 17 Sep, 2019
Reviewer #2 agreed
On 17 Sep, 2019
Reviewers invited
Invitations sent on 16 Sep, 2019
Submission checks complete
On 13 Sep, 2019
Editor assigned
On 03 Sep, 2019
Editor invited
On 02 Sep, 2019
First submitted
On 30 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
Learn more about our company.
See the published version of this preprint at BMC Anesthesiology.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Sang Sik Choi
Korea University Guro Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0260-9886
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Anesthesiology.
No community comments so far
Reviewer #1 agreed
On 16 Jan, 2020
Review #1 received
Received 16 Jan, 2020
Editor assigned
On 15 Jan, 2020
Reviewers invited
Invitations sent on 15 Jan, 2020
Submission checks complete
On 14 Jan, 2020
Editor invited
On 14 Jan, 2020
No comments provided
Reviewer #3 agreed
On 05 Jan, 2020
Review #3 received
Received 05 Jan, 2020
Editorial decision: Major revision
On 05 Jan, 2020
Review #2 received
Received 28 Nov, 2019
Reviewer #2 agreed
On 10 Nov, 2019
Review #1 received
Received 05 Nov, 2019
Editor assigned
On 21 Oct, 2019
Reviewers invited
Invitations sent on 21 Oct, 2019
Reviewer #1 agreed
On 21 Oct, 2019
Submission checks complete
On 20 Oct, 2019
Editor invited
On 20 Oct, 2019
Version 1
Posted 19 Sep, 2019
No comments provided
Editorial decision: Major revision
On 30 Sep, 2019
Reviewer #1 agreed
On 17 Sep, 2019
Review #1 received
Received 17 Sep, 2019
Review #2 received
Received 17 Sep, 2019
Reviewer #2 agreed
On 17 Sep, 2019
Reviewers invited
Invitations sent on 16 Sep, 2019
Submission checks complete
On 13 Sep, 2019
Editor assigned
On 03 Sep, 2019
Editor invited
On 02 Sep, 2019
First submitted
On 30 Aug, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Anesthesiology.
Background Continuous epidural block is commonly used in clinical settings and reduces the likelihood of transition to postherpetic neuralgia via pain control. The purpose of the present study was to compare the efficacies of conventional continuous epidural block and continuous epidural block involving electric stimulation-guided localization of the catheter to areas with neurological damage, in the treatment of herpes zoster pain and prevention of postherpetic neuralgia.
Methods We analyzed the medical records of 114 patients in the present study. The patients were divided into two groups: esopocan (conventional continuous epidural block) and epistim (continuous epidural block with epidural electric stimulation). In the esopocan group, the position of the epidural catheter was confirmed using contrast medium alone, whereas in the epistim group, the site of herpes zoster infection was identified through electric stimulation using the guidewire in the catheter. Clinical efficacy was assessed using a numerical rating scale (pain score) up to 6 months after the procedures. We compared the percentage of patients who showed complete remission (pain score less than 2 and no further medication) in each group. We also investigated whether the patients required additional interventional treatment due to insufficient pain control during the 6 month follow-up period after each procedure.
Results After adjusting for confounding variables, the pain score was significantly lower in the epistim group than in the esopocan group for 6 months after the procedure. The adjusted odds ratio of patients included in the complete remission category was 1.9 times higher in the epistim group than the esopocan group (95% confidence interval: 0.81-4.44, P = 0.14). The adjusted odds ratio for other interventions within 6 months after the procedure was 3.62 times higher in the esopocan group than the epistim group (95% confidence interval: 1.17-11.19, P = 0.03).
Conclusion Epidural drug administration to specific spinal segments using electrical stimulation catheters may be more helpful than conventional continuous epidural block in improving pain and preventing postherpetic neuralgia in acute herpes zoster.
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
Loading...