We study the major Mw 7.0, 30 October 2020, Samos earthquake and its aftershocks, by calculating improved locations using differential travel times and waveform cross-correlations.We image the rupture of the mainshock using local strong motion data, and we examine the Coulomb stress evolution prior to the mainshock, as well as the coseismic stress changes. Lastly, we estimate the produced shaking using all the available information from strong motion data and testimonies. Earthquake relocations reveal the activation of the E-W oriented, Kaystrios fault, in the North basin of Samos with a possible extension to the West. The kinematic rupture inversion suggests non-uniform bilateral rupture on a ~60 km × ~20 km fault area, with the main rupture propagating towards the West and maximum slip up to approximately 2.5 m. Improved locations of the aftershock sequence are anti-correlated with areas of maximum slip on the fault surface. Similarly, the Coulomb stress change calculations show that only off-fault earthquake clusters are located within lobes of increasing positive static stress changes. This observation is consistent with assuming a fault area of either uniform slip, or variable slip according to the obtained slip model. Both scenarios indicate typical stress patterns for a normal fault with E-W orientation, with stress lobes of positive ΔCFF increments expanding in E-W orientation. In the case of the variable slip model, both negative and positive stress changes show slightly larger values compared to the uniform slip model. Finally, Modified Mercalli Intensities based on the fault model obtained in this study indicate maximum intensity (VII+) in the North Samos island. Spectral acceleration values at 0.3 s period also demonstrate the damaging situation at Izmir.