Investigating effects of preoperative inflammatory biomarkers on predicting survival outcomes of intrahepatic cholangiocarcinoma after curative resection.
Introduction: Intrahepatic cholangiocarcinoma (ICC) stands as the second most common malignant tumor in liver with poor patient prognosis. Increasing evidences have shown that inflammation plays a significant role in tumor progression, angiogenesis and metastasis. However, the prognosis significance of inflammatory biomarkers on recurrence-free survival (RFS) and overall survival (OS) in ICC patients is poorly recognized.
Methods: ICC patients who underwent curative hepatectomy and diagnosed pathologically were retrospectively analyzed. Inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), were investigated.
Results: Receiver operating characteristic (ROC) curves showed no significance in NLR, PLR and LMR in RFS and OS, while significant results were shown on SII in both RFS (P=0.035) and OS (P=0.034) with areas under ROC curve as 0.63 (95%CI: 0.52-0.74) and 0.62 (95%CI: 0.51-0.72), respectively. Kaplan-Meier curves revealed statistically significant better survival data in SII-low groups on both RFS (P<0.001) and OS (P<0.001). The univariate and multivariate analyses revealed that higher level of SII was independently associated with both poorer RFS time and OS time. However, no significant result was shown on NLR, PLR or LMR.
Conclusion: SII is an effective prognostic factor for predicting the prognosis of ICC patient undergone curative hepatectomy, while NLR, PLR and LMR are not associated with clinical outcomes of these patients.
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Posted 21 Oct, 2020
On 23 Oct, 2020
On 13 Oct, 2020
On 12 Oct, 2020
On 11 Oct, 2020
On 11 Oct, 2020
On 28 Sep, 2020
Received 22 Sep, 2020
Received 19 Sep, 2020
On 14 Sep, 2020
Invitations sent on 14 Sep, 2020
On 14 Sep, 2020
On 14 Sep, 2020
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On 04 Aug, 2020
On 04 Aug, 2020
On 03 Aug, 2020
On 03 Aug, 2020
Investigating effects of preoperative inflammatory biomarkers on predicting survival outcomes of intrahepatic cholangiocarcinoma after curative resection.
Posted 21 Oct, 2020
On 23 Oct, 2020
On 13 Oct, 2020
On 12 Oct, 2020
On 11 Oct, 2020
On 11 Oct, 2020
On 28 Sep, 2020
Received 22 Sep, 2020
Received 19 Sep, 2020
On 14 Sep, 2020
Invitations sent on 14 Sep, 2020
On 14 Sep, 2020
On 14 Sep, 2020
On 13 Sep, 2020
On 13 Sep, 2020
On 10 Sep, 2020
Received 05 Sep, 2020
Received 25 Aug, 2020
On 15 Aug, 2020
On 14 Aug, 2020
Invitations sent on 05 Aug, 2020
On 04 Aug, 2020
On 04 Aug, 2020
On 03 Aug, 2020
On 03 Aug, 2020
Introduction: Intrahepatic cholangiocarcinoma (ICC) stands as the second most common malignant tumor in liver with poor patient prognosis. Increasing evidences have shown that inflammation plays a significant role in tumor progression, angiogenesis and metastasis. However, the prognosis significance of inflammatory biomarkers on recurrence-free survival (RFS) and overall survival (OS) in ICC patients is poorly recognized.
Methods: ICC patients who underwent curative hepatectomy and diagnosed pathologically were retrospectively analyzed. Inflammatory biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune-inflammation index (SII), were investigated.
Results: Receiver operating characteristic (ROC) curves showed no significance in NLR, PLR and LMR in RFS and OS, while significant results were shown on SII in both RFS (P=0.035) and OS (P=0.034) with areas under ROC curve as 0.63 (95%CI: 0.52-0.74) and 0.62 (95%CI: 0.51-0.72), respectively. Kaplan-Meier curves revealed statistically significant better survival data in SII-low groups on both RFS (P<0.001) and OS (P<0.001). The univariate and multivariate analyses revealed that higher level of SII was independently associated with both poorer RFS time and OS time. However, no significant result was shown on NLR, PLR or LMR.
Conclusion: SII is an effective prognostic factor for predicting the prognosis of ICC patient undergone curative hepatectomy, while NLR, PLR and LMR are not associated with clinical outcomes of these patients.
Figure 1
Figure 2