Objective: To observe the effects of insulin injection technique (IT) on short- or long-run glycemic control in type 2 diabetic patients (T2D) with long-acting insulin analogue.
Methods: This was a single-center, cross-over, observational and open-labled study. Patients with T2D receiving long-acting insulin analogue insulin were enrolled as inpatients. The study period lasting for 5 days including a 1-day screen period and 4-day continuous glucose monitoring (CGM) period. During CGM period, patients injected insulin themselves from day 1 to day 2, and patient’s insulin IT was given by two independent specialist nurses, with insulin injected by nurses from day 3 to day 4. The primary endpoint was the correlation between the insulin IT and the mean amplitude of glycemic excursion (MAGE).
Results: A total of 60 diabetic inpatients were recruited and completed the study. The mean score of patients’ insulin IT of patients was lower than that of nurses (p<0.05). We observed that the MAGE value was significant different between the two injections period (P<0.05), and needle reuse and rotation of injection site were negatively correlated to MAGE and HbA1c values, respectively.
Conclusion: Insulin IT was negatively correlation to short- or long-run glycemic control in T2D patients with long-acting insulin analogue therapy.