This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Thanyalak Amornpojnimman
Prince of Songkla University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8673-7040
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Despite less common, cerebellar stroke frequently results in unfavorable outcomes, especially after deterioration. Therefore, this study was aimed to identify the significant predictors of neurological deterioration during admission (NDDA) in ischemic and hemorrhagic cerebellar strokes.
Materials and methods: We retrospectively reviewed all medical records of the patients diagnosed with ischemic and hemorrhagic cerebellar strokes during 2002-2018 in Songklanagarind hospital. Comparison of patients’ demographic data, initial clinical presentations, neuroradiological results, timing and signs of NDDA, and outcomes between cerebellar strokes were descriptively analyzed. Logistic regression model was applied for determining the significant predictors of NDDA from initial clinical presentations.
Results: 74 of 100 patients were eligible. They comprised of 42 (57%) cerebellar ischemia (CI) and 32 (43%) cerebellar hemorrhage (CH). Elevated diastolic blood pressure (DBP) and the neuro-radiological evidences suggesting increased posterior cranial fossa pressure were significantly prevalent in neurological deterioration patients. NDDA was found in 31 patients (42%) without significant difference between CI and CH. 42 (56.8%) patients had poor neurological outcomes. The independent predictors for NDDA were DBP B 120 mmHg (adjusted odds ratio [adj. OR] 15.39, 95% CI 1.58-149.59; p = 0.004), time from onset to arrival (adj. OR 0.98, 95% CI 0.97-1.00; p = 0.044), and hemispheric cerebellar signs (adj. OR 0.22, 95% CI 0.06-0.75; p = 0.012).
Conclusions: CH was not an independent predictor of NDDA in overall cerebellar strokes. Only high DBP predicted NDDA, whereas time to arrival and hemispheric signs showed protective impact.
Keywords
Predictors, Cerebellar strokes, Neurological deterioration, During admission
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Thanyalak Amornpojnimman
Prince of Songkla University
Corresponding Author
ORCiD: https://orcid.org/0000-0002-8673-7040
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
View the published article at Journal of Health Science and Medical Research.
Version 1
Posted 14 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Neurology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at Journal of Health Science and Medical Research.
Background: Despite less common, cerebellar stroke frequently results in unfavorable outcomes, especially after deterioration. Therefore, this study was aimed to identify the significant predictors of neurological deterioration during admission (NDDA) in ischemic and hemorrhagic cerebellar strokes.
Materials and methods: We retrospectively reviewed all medical records of the patients diagnosed with ischemic and hemorrhagic cerebellar strokes during 2002-2018 in Songklanagarind hospital. Comparison of patients’ demographic data, initial clinical presentations, neuroradiological results, timing and signs of NDDA, and outcomes between cerebellar strokes were descriptively analyzed. Logistic regression model was applied for determining the significant predictors of NDDA from initial clinical presentations.
Results: 74 of 100 patients were eligible. They comprised of 42 (57%) cerebellar ischemia (CI) and 32 (43%) cerebellar hemorrhage (CH). Elevated diastolic blood pressure (DBP) and the neuro-radiological evidences suggesting increased posterior cranial fossa pressure were significantly prevalent in neurological deterioration patients. NDDA was found in 31 patients (42%) without significant difference between CI and CH. 42 (56.8%) patients had poor neurological outcomes. The independent predictors for NDDA were DBP B 120 mmHg (adjusted odds ratio [adj. OR] 15.39, 95% CI 1.58-149.59; p = 0.004), time from onset to arrival (adj. OR 0.98, 95% CI 0.97-1.00; p = 0.044), and hemispheric cerebellar signs (adj. OR 0.22, 95% CI 0.06-0.75; p = 0.012).
Conclusions: CH was not an independent predictor of NDDA in overall cerebellar strokes. Only high DBP predicted NDDA, whereas time to arrival and hemispheric signs showed protective impact.
Figure 1
Figure 2
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