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Young-Onset Colorectal Cancer in the North East of Scotland: Survival, Clinico-Pathological Features and Genetics
Sarah Perrott
University of Aberdeen
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1415-7271
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cancer.
Background Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. Methods A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005-2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes then crosschecked with the NHS Grampian genetics electronic case records. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral. Results Data from 345 patients (age range 22-54 years) were identified. The one year, five year and overall survival rates were found to be 89%, 63% and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetics services. Microsatellites instability (MSI) was identified in 14% of those referred. Conclusions Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.
Keywords
Young-onset colorectal cancer; Survival; Clinicopathological characteristics; Genetic referral; Microsatellite instability
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CURRENT STATUS: Published
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On 10 Feb, 2020
No community comments so far
Editorial decision: Accept
On 04 Feb, 2020
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Invitations sent on 10 Jan, 2020
Editor assigned
On 06 Jan, 2020
Editor invited
On 05 Jan, 2020
Submission checks complete
On 29 Dec, 2019
No comments provided
Review #2 received
Received 10 Dec, 2019
Editorial decision: Major revision
On 10 Dec, 2019
Reviewer #2 agreed
On 22 Nov, 2019
Reviewer #1 agreed
On 22 Sep, 2019
Review #1 received
Received 22 Sep, 2019
Reviewers invited
Invitations sent on 20 Sep, 2019
Submission checks complete
On 17 Sep, 2019
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On 15 Sep, 2019
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On 14 Sep, 2019
First submitted
On 13 Sep, 2019
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This preprint is under consideration at BMC Cancer. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Young-Onset Colorectal Cancer in the North East of Scotland: Survival, Clinico-Pathological Features and Genetics
Sarah Perrott
University of Aberdeen
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1415-7271
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 2
Posted 02 Jan, 2020
Published
On 10 Feb, 2020
No community comments so far
Editorial decision: Accept
On 04 Feb, 2020
Reviewers invited
Invitations sent on 10 Jan, 2020
Editor assigned
On 06 Jan, 2020
Editor invited
On 05 Jan, 2020
Submission checks complete
On 29 Dec, 2019
No comments provided
Review #2 received
Received 10 Dec, 2019
Editorial decision: Major revision
On 10 Dec, 2019
Reviewer #2 agreed
On 22 Nov, 2019
Reviewer #1 agreed
On 22 Sep, 2019
Review #1 received
Received 22 Sep, 2019
Reviewers invited
Invitations sent on 20 Sep, 2019
Submission checks complete
On 17 Sep, 2019
Editor assigned
On 15 Sep, 2019
Editor invited
On 14 Sep, 2019
First submitted
On 13 Sep, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Cancer.
Background Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC), as well as audit the referral rate to genetic services and thus establish the incidence of inherited cancer syndromes. Methods A retrospective case note review was conducted for patients aged under 55 years who were diagnosed with CRC between 2005-2015 in the North East of Scotland. Cases were identified by pathology records and data was obtained from patient notes then crosschecked with the NHS Grampian genetics electronic case records. Analysis was performed using SPSS version 25 (IBM, New York, USA) to produce Kaplan-Meier survival estimates, descriptive statistics and markers predictive for genetic referral. Results Data from 345 patients (age range 22-54 years) were identified. The one year, five year and overall survival rates were found to be 89%, 63% and 55%, respectively. Most patients (61%) presented with advanced disease. Of 201 patients that met criteria for genetic referral, only 93 (46%) were referred to genetics services. Microsatellites instability (MSI) was identified in 14% of those referred. Conclusions Survival in yCRC was found to be better than that in later onset disease, despite higher rates of advanced disease. Patients were under-referred to genetic services, where a significant proportion were found to be MSI positive and investigated for Lynch syndrome.
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