1. SIEGEL R L, MILLER K D, JEMAL A. Cancer statistics, 2019[J]. CA Cancer J Clin, 2019, 69(1): 7-34.
2.FENG R M, ZONG Y N, CAO S M, et al. Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?[J]. Cancer Commun (Lond), 2019, 39(1):22.
3.Qian Yaner. Combined detection of tumor markers in the diagnosis of pancreatic cancer [J]; and Journal of Medical Research ,2011,40(6):147149.
4.Kuja-Panula J, Kiiltomäki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol. 2003 Mar 17;160(6):963-73. doi: 10.1083/jcb.200209074. Epub 2003 Mar 10. PMID: 12629050; PMCID: PMC2173769.
5.Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG. AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. J Cell Biol. 2015 Nov 9;211(3):619-37. doi: 10.1083/jcb.201503113. PMID: 26553931; PMCID: PMC4639856.
6.Kajander T., Kuja-Panula J., Rauvala H. & Goldman A. Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1. J Mol Biol 413, 1001–1015, doi: 10.1016/j.jmb.2011.09.032 (2011).
7.Richardson, A.L., Wang, Z.C., De Nicolo, A., et al. (2006) X Chromosomal Abnormalities in Basal-Like Human Breast Cancer. Cancer Cell, 9, 121-132. https://doi.org/10.1016/j.ccr.2006.01.013
8.Sun, L., Hui, A.M., Su, Q., et al. (2006) Neuronal and Glioma-Derived Stem Cell Factor Induces Angiogenesis within the Brain. Cancer Cell, 9, 287-300. https://doi.org/10.1016/j.ccr.2006.03.003
9.Lapointe, J., Li, C., Higgins, J.P., et al. (2004) Gene Expression Profiling Identifies Clinically Relevant Subtypes of Prostate Cancer. Proceedings of the National Academy of Sciences of the United States of America, 101, 811-816. https://doi.org/10.1073/pnas.0304146101
10. Kan Liang, Zhang Meng, He Ping. The down-regulation of LRRC3B expression in non-small cell lung cancer and its correlation with high TNM stage and lymph node metastasis [J].].1 Chinese Journal of Medical Frontier (Electronic Edition),2016,8(5):131-135.
11.Fukuma, M., Tanese, K., Effendi, K., Yamazaki, K., Masugi, Y., Suda, M., et al. (2013) Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 Regulates Epithelial Cell Phenotype and Survival of Hepatocellular Carcinoma Cells. Experimental Cell Research, 319, 113-121.
12.Yamanoi, K., Fukuma, M., Uchida, H., Kushima, R., Yamazaki, K., Katai, H., et al. (2013) Overexpression of Leu-cine-Rich Repeat-Containing G Protein-Coupled Receptor 5 in Gastric Cancer. Pathology International, 63, 13-19
13.Tanese, K., Fukuma, M., Yamada, T., Mori, T., Yoshikawa, T., Watanabe, W., et al. (2008) G-Protein-Coupled Receptor GPR49 Is Up-Regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation. The American Journal of Pathology, 173, 835-843.
14.McClanahan, T., Koseoglu, S., Smith, K., Grein, J., Gustafson, E., Black, S., et al. (2006) Identification of Over expression of Orphan G Protein-Coupled Receptor GPR49 in Human Colon and Ovarian Primary Tumors. Cancer Biology & Therapy, 5, 419-426.
15.Rabenau K. E. et al.. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity.Oncogene 23,5056–5067, doi: 10.1038/sj.onc.1207681 (2004).
16.Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019 Jul 2;47(W1):W556-W560. doi: 10.1093/nar/gkz430. PMID: 31114875; PMCID: PMC6602440.
17.Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Rodriguez IP, Chakravarthi BVSK and Varambally S. UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017 Aug;19(8):649-658. doi: 10.1016/j.neo.2017.05.002 [PMID:28732212]
18.Asplund A, Edqvist PH, Schwenk JM, Pontén F. Antibodies for profiling the human proteome-The Human Protein Atlas as a resource for cancer research. Proteomics. 2012; 12:2067–77. https://doi.org/10.1002/pmic.201100504
19.Li T, Fu J, Zeng Z, Cohen D, Li J, Chen Q, Li B, Liu XS. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 2020 Jul 2;48(W1):W509-W514. doi: 10.1093/nar/gkaa407. PMID: 32442275; PMCID: PMC7319575.
20.Nagy A, Lánczky A, Menyhárt O, Győrffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets, Scientific Reports, 2018;8:9227
21.Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44-57. doi: 10.1038/nprot.2008.211. PMID: 19131956.
22.Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019 Apr 3;10(1):1523. doi: 10.1038/s41467-019-09234-6. PMID: 30944313; PMCID: PMC6447622.
23.Rouillard AD, Gundersen GW, Fernandez NF, Wang Z, Monteiro CD, McDermott MG, Ma'ayan A. The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford). 2016 Jul 3;2016. pii: baw100.
24.Fornes O, Castro-Mondragon JA, Khan A, van der Lee R, Zhang X, Richmond PA, Modi BP, Correard S, Gheorghe M, Baranašić D, Santana-Garcia W, Tan G, Chèneby J, Ballester B, Parcy F, Sandelin A, Lenhard B, Wasserman WW, Mathelier A. JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2020 Jan 8;48(D1):D87-D92. doi: 10.1093/nar/gkz1001. PMID: 31701148; PMCID: PMC7145627.
25.Li L, Zhang JW, Jenkins G, Xie F, Carlson EE, Fridley BL, Bamlet WR, Petersen GM, McWilliams RR, Wang L. Genetic variations associated with gemcitabine treatment outcome in pancreatic cancer. Pharmacogenet Genomics. 2016 Dec;26(12):527-537. doi: 10.1097/FPC.0000000000000241. PMID: 27749787; PMCID: PMC5083195.
26.Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S. Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma. Oncotarget. 2017 May 29;8(32):53180-53193. doi: 10.18632/oncotarget.18261. PMID: 28881803; PMCID: PMC5581102.
27.Fornes O, Castro-Mondragon JA, Khan A, van der Lee R, Zhang X, Richmond PA, Modi BP, Correard S, Gheorghe M, Baranašić D, Santana-Garcia W, Tan G, Chèneby J, Ballester B, Parcy F, Sandelin A, Lenhard B, Wasserman WW, Mathelier A. JASPAR 2020: update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2020 Jan 8;48(D1):D87-D92. doi: 10.1093/nar/gkz1001. PMID: 31701148; PMCID: PMC7145627.
28.Kuja-Panula J, Kiiltomäki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol. 2003 Mar 17;160(6):963-73. doi: 10.1083/jcb.200209074. Epub 2003 Mar 10. PMID: 12629050; PMCID: PMC2173769.
29.Watts AD, Hunt NH, Wanigasekara Y, Bloomfield G, Wallach D, Roufogalis BD, Chaudhri G. A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'. EMBO J. 1999 Apr 15;18(8):2119-26. doi: 10.1093/emboj/18.8.2119. PMID: 10205166; PMCID: PMC1171296.
30.Tekin C, Aberson HL, Bijlsma MF, Spek CA. Early macrophage infiltrates impair pancreatic cancer cell growth by TNF-α secretion. BMC Cancer. 2020 Dec 2;20(1):1183. doi: 10.1186/s12885-020-07697-1. PMID: 33267818; PMCID: PMC7709323.
31.Malsy M, Graf B, Almstedt K. The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer. BMC Biochem. 2019 Jan 29;20(1):2. doi: 10.1186/s12858-019-0105-4. PMID: 30696421; PMCID: PMC6352339.
32.Kanda Y, Osaki M, Onuma K, Sonoda A, Kobayashi M, Hamada J, Nicolson GL, Ochiya T, Okada F. Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases. Sci Rep. 2017 Mar 8;7:43567. doi: 10.1038/srep43567. PMID: 28272394; PMCID: PMC5341090.
33.Nakamura T, Kuwai T, Kitadai Y, Sasaki T, Fan D, Coombes KR, Kim SJ, Fidler IJ. Zonal heterogeneity for gene expression in human pancreatic carcinoma. Cancer Res. 2007 Aug 15;67(16):7597-604. doi: 10.1158/0008-5472.CAN-07-0874. PMID: 17699763.
34.Hwang RF, Gordon EM, Anderson WF, Parekh D. Gene therapy for primary and metastatic pancreatic cancer with intraperitoneal retroviral vector bearing the wild-type p53 gene. Surgery. 1998 Aug;124(2):143-50; discussion 150-1. PMID: 9706132.
35.Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK. Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol. 2018 Jun 20;16(6):e2004049. doi: 10.1371/journal.pbio.2004049. PMID: 29924804; PMCID: PMC6042798.
36.Park H, Lee S, Shrestha P, Kim J, Park JA, Ko Y, Ban YH, Park DY, Ha SJ, Koh GY, Hong VS, Mochizuki N, Kim YM, Lee W, Kwon YG. AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. J Cell Biol. 2015 Nov 9;211(3):619-37. doi: 10.1083/jcb.201503113. PMID: 26553931; PMCID: PMC4639856.
37.Sharmin Hossain, Minhaz Uddin Ahmed, Shamiul Alam, Akuo Watanabe, Ai Harashima, Hideto Yonekura and Hiroshi Yamamoto, 2011. Expression and Roles of AMIGO Gene Family in Vascular Endothelial Cells. International Journal of Molecular Medicine and Advance Sciences, 7: 5-11.
38.Fontanals-Cirera B, Hasson D, Vardabasso C, Di Micco R, Agrawal P, Chowdhury A, Gantz M, de Pablos-Aragoneses A, Morgenstern A, Wu P, Filipescu D, Valle-Garcia D, Darvishian F, Roe JS, Davies MA, Vakoc CR, Hernando E, Bernstein E. Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene. Mol Cell. 2017 Nov 16;68(4):731-744.e9. doi: 10.1016/j.molcel.2017.11.004. PMID: 29149598; PMCID: PMC5993436.
39.Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene. 2004 Jun 24;23(29):5056-67. doi: 10.1038/sj.onc.1207681. PMID: 15107827.
40.Yang J, Siqueira MF, Behl Y, Alikhani M, Graves DT. The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. FASEB J. 2008 Nov;22(11):3956-67. doi: 10.1096/fj.08-111013. Epub 2008 Aug 1. PMID: 18676404; PMCID: PMC2574028.
41.Yang J, Siqueira MF, Behl Y, Alikhani M, Graves DT. The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. FASEB J. 2008 Nov;22(11):3956-67. doi: 10.1096/fj.08-111013. Epub 2008 Aug 1. PMID: 18676404; PMCID: PMC2574028.
42.Wallrapp C, Müller-Pillasch F, Solinas-Toldo S, Lichter P, Friess H, Büchler M, Fink T, Adler G, Gress TM. Characterization of a high copy number amplification at 6q24 in pancreatic cancer identifies c-myb as a candidate oncogene. Cancer Res. 1997 Aug 1;57(15):3135-9. PMID: 9242439.
43.Yang K, He M, Cai Z, Ni C, Deng J, Ta N, Xu J, Zheng J. A decrease in miR-150 regulates the malignancy of pancreatic cancer by targeting c-Myb and MUC4. Pancreas. 2015 Apr;44(3):370-9. doi: 10.1097/MPA.0000000000000283. PMID: 25522282.
44.Taniguchi Y, London R, Schinkmann K, Jiang S, Avraham H. The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and Is associated with the c-Kit receptor. Blood. 1999 Jul 15;94(2):539-49. PMID: 10397721.
45.Yan HX, He YQ, Dong H, Zhang P, Zeng JZ, Cao HF, Wu MC, Wang HY. Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. Biochemistry. 2002 Dec 31;41(52):15854-60. doi: 10.1021/bi026095u. PMID: 12501215.
46.Lillehoj EP, Lu W, Kiser T, Goldblum SE, Kim KC. MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism. Biochim Biophys Acta. 2007 Jul;1773(7):1028-38. doi: 10.1016/j.bbamcr.2007.04.009. Epub 2007 Apr 22. PMID: 17524503; PMCID: PMC2349984.