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Research article
Chih-Ken Chen
Chang Gung Memorial Hospital
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
Background Depression presents with emotional and somatic symptoms, and sometimes cognitive complaints. On the other hand, depression is one of the important psychiatric symptoms of mild cognitive impairment and dementia.
Methods Residents who were older than 50 years reported their depressive tendency using the Taiwanese Depression Questionnaire (TDQ) and cognitive complaints using the AD8 questionnaire and were assessed using the Mini-International Neuropsychiatric Interview (MINI) and for objective cognitive evaluation using the Mini-Mental State Examination (MMSE).
Results TDQ score (OR 1.154, p = 0.003) and AD8 score (OR 1.769, p = 0.018) were statistically significant in predicting current major depressive disorder (MDD) when adjustment were made for age, sex, sleep quality and cognitive performance. However, in elderly people with age ≥ 65, TDQ score failed to distinguish a diagnosis of current MDD from no such diagnosis (AUC 0.780, p = 0.063). A linear combination of TDQ and AD8 scores provided a new predictive score that successfully separated elderly people with MDD from those without it (AUC 0.875, p = 0.013). Finally, decision-tree learning was used to generate a classification tree for classifying people with and without current MDD. At the first decision level, value less than 29 from the sum of TDQ score and 4 folds of AD8 score 100% excluded people without current MDD.
Conclusions The self-reported response to the TDQ is a feasible way to identify MDD in community-dwelling people. Combining TDQ and AD8 scores further improved detecting depression in older people in communities.
Keywords
Geriatric depression; Major depressive disorder; Taiwanese Depression Questionnaires; Subjective cognitive complaint; AD8.
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Chih-Ken Chen
Chang Gung Memorial Hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background Depression presents with emotional and somatic symptoms, and sometimes cognitive complaints. On the other hand, depression is one of the important psychiatric symptoms of mild cognitive impairment and dementia.
Methods Residents who were older than 50 years reported their depressive tendency using the Taiwanese Depression Questionnaire (TDQ) and cognitive complaints using the AD8 questionnaire and were assessed using the Mini-International Neuropsychiatric Interview (MINI) and for objective cognitive evaluation using the Mini-Mental State Examination (MMSE).
Results TDQ score (OR 1.154, p = 0.003) and AD8 score (OR 1.769, p = 0.018) were statistically significant in predicting current major depressive disorder (MDD) when adjustment were made for age, sex, sleep quality and cognitive performance. However, in elderly people with age ≥ 65, TDQ score failed to distinguish a diagnosis of current MDD from no such diagnosis (AUC 0.780, p = 0.063). A linear combination of TDQ and AD8 scores provided a new predictive score that successfully separated elderly people with MDD from those without it (AUC 0.875, p = 0.013). Finally, decision-tree learning was used to generate a classification tree for classifying people with and without current MDD. At the first decision level, value less than 29 from the sum of TDQ score and 4 folds of AD8 score 100% excluded people without current MDD.
Conclusions The self-reported response to the TDQ is a feasible way to identify MDD in community-dwelling people. Combining TDQ and AD8 scores further improved detecting depression in older people in communities.
Figure 1
Figure 2
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