Dr Kalfon has received consulting fees from Philips Healthcare and General Electric Healthcare. On behalf of all remaining authors, the corresponding author states that the remaining authors have non conflict of interest.
Acknowledgments: We thank the nursing staff and doctors whose enthusiasm and work made this clinical trial possible. We especially thank Anderson Loundou (Unité de recherche EA3279, Aix-Marseille Université) for participating in the statistical analysis. We particularly thank Anderson Loundou (Unité de recherche EA3279, Aix-Marseille Université) for participating in the statistical analysis, Bénédicte Mauchien (CH de Chartres) for her major and invaluable role in providing technical and educational support to all the investigators under the supervision of the lead investigator, and Claude Martin† (CHU Hôpital Nord, AP-HM) for participating in the steering committee of the IPREA3 study.
Members of the IPREA study group:
Co-investigators and collaborators (listed alphabetically by institution, all in France) from Centre Hospitalier (CH) d’Auxerre: Karine Vie; Centre Hospitalier (CHU) de Brest: Gwenaëlle Lannuzel; CHU Beaujon, Assistance Publique-Hôpitaux de Paris (AP-HP): Hélène Bout; CHU Dijon Bourgogne: Jean-Philippe Parthiot, Isabelle Chazal, Philippe Charve, Caroline Prum, Jean-Pierre Quenot, Nora Perrot, Francis Augier, Niloufar Behechti, Claudine Cocusse, Céline Foulon, Laurence Goncalves, Abdesselem Hanchi, Etienne Legros, Ana Isabel Mercier, Nicolas Meunier-Beillard, Nathalie Nuzillat, and Alicia Richard; CH de Douai: Claire Boulle, Benjamin Kowalski, and Elisa Klusek; CHU Raymond Poincaré, AP-HP: Tarek Sharshar, Andrea Polito, Caroline Duvallet, and Sonia Krim; Groupe Hospitalier de La Rochelle-Ré-Aunis: Nicolas Girard; CH de Chartres: Juliette Audibert-Souhaid, Cécile Jourdain, and Stéphane Techer; CH Emile Roux, Le Puy-en-Velay: Corinne Chauvel, and Corinne Bruchet; CH de Lens: Johanna Temime, Stéphanie Beaussart, and Fabienne Jarosz; CHU Edouard Herriot, Hospices Civils de Lyon: Julien Crozon-Clauzel, Serge Olousouzian, Sylvie Pereira, Loïc Argentin, and Valérie Cerro; Hôpital Européen de Marseille: Déborah Levy; CHU Hôpital Nord, Assistance Publique Hôpitaux de Marseille: Sébastien Andre, Christophe Guervilly, Laurent Papazian, and Myriam Moussa; Clinique Ambroise Paré, Neuilly/Seine: Stéphanie Renoult, Delphine Biet, and Steve Novak; CHU Nice: Jean-Christophe Orban, Aminata Diop, and Carole Ichai; CHU Cochin, AP-HP: Antoine Tesniere, Jean-Pascal Goupil, and Frédérique Laville; CHU Hôpital Européen Georges Pompidou, AP-HP: Nadège Rutter; Groupe Hospitalier Paris Saint-Joseph: Sandie Brochon, and Kelly Tiercelet; CHU Pitié-Salpêtrière, AP-HP: Julien Amour, Nora Ait-Hamou, and Marjorie Leger; CHU Saint-Louis, AP-HP: Virginie Souppart; CHU La Milétrie, Poitiers: Emilie Griffault, Marie-Line Debarre, Céline Deletage, Anne-Laure Guerin, Carole Guignon, and Sabrina Seguin; CH Victor Provo, Roubaix: Christophe Hart, and Kathy Dernivoix; CHU Strasbourg: Caroline Wuiot, Karine Sanches, and Stéphane Hecketsweiler; Centre Hospitalier Intercommunal Toulon/La Seyne sur mer: Catherine Sylvestre-Marconville and Vincent Gardan; and CH de Troyes: Stéphanie Deparis-Dusautois and Yana Chaban.
Authors’contributions: PK was principal investigator and obtained funding. PK, KB, M-AG, EA, OM, and PA conceptualized and designed the IPREA3 study. PK, PE, M-AG, AB, GS, BF, TS, MF, MN, JA, ABS, AS, MV, RR, AF, AR, MG-O, OC, QL, IV, DT, TP, R-GP, NR, CR, and OM collected the data. PK, and BM coordinated the study and supervised data collection. MB, KB, and PA performed statistical analysis. PK, KB, MB, and PA analyzed and interpreted the data. PK and KB drafted the manuscript. PK, KB, and PA revised the manuscript for important intellectual content. All authors approved the final manuscript. PK had full access to all data of the study and had final responsibility for the decision to submit the manuscript.
Funding: This research was financially supported by a grant from the Programme Hospitalier de Recherche Clinique National, 2012, 12-010-0554, funded by the French Ministry of Health.
Availability of data and materials: The datasets used and analyzed during the current study are available fromthe corresponding author in response to reasonable requests.
Ethics approval and consent to participate: Regulatory monitoring was performed in accordance with the French law requiring the approval of the French ethics committee (Comité de Protection des Personnes Tours region Centre-Ouest 1, 28/08//2013, reference number 2013-S10). All records and patient identities remained confidential in accordance with the regulations of the French National Committee of Informatics and Liberties (Commission nationale de l’informatique et des libertés, 20/03/2014, reference number DR-2014-097) and the French Consultative Committee for data processing in health research (Comité consultative sur le traitement de l’information en matière de recherche dans le domaine de la santé, 12/12/2013, reference number 13.642bis). Consent was obtained from all participants.
Consent for publication: Not applicable.
Conflicts of interest Dr Kalfon received consulting fees from Philips Healthcare and General Electric Healthcare. On behalf of all remaining authors, the corresponding author states that the remaining authors have no conflict of interest.