Cancer is the most genuine motivation of death around the world, in 2016, 1.7 millon new malignancy (cancer) cases and 595690 disease passings are projected to occur in USA (Siegel et al., 2014). With 12.7 million cases in 2008, and it is normal that 27 million new cases will be analyzed in 2030. In addition, approximately 47% of disease cases and 55 % of its mortality occur in less created areas of the world (Jemal et al., 2011).
Breast disease is the second most incessant worldwide and the most well-known sort of malignancy among ladies, being liable for about 1.38 million new cases every year, and adding to around 458,000 passings, as per the World Health (DeSantis et al., 2014). Ehrlich tumor carcinoma is a transplantable, ineffectively separated dangerous tumor which showed up initially as an unconstrained bosom carcinoma in a mouse (El-Masry et al., 2019, 2020a; Abd Eldaim et al., 2021a). It fills in both solid and ascitic structures (Mutar et al., 2020; Alotaibi et al., 2021). At the point when the ascites liquids that is initially hyper diploid and it is 100% harm vaccinated intraperitoneal it created to EAC and whenever infused subcutaneously it created to EST (Abd Eldaim et al., 2019; Tousson et al., 2020).
Most methodologies treatments that utilized in disease therapy is chemotherapy that murder malignancy cells by instigating apoptosis and causes seriously influence the existence of patients and address an immediate reason for death (Tousson et al., 2014, 2016). Over 40% of remedial medications were delivered dependent on normal items and their subordinates in the previous many years (Alotaibi et al., 2020).
Spirulina is filamentous blue-green microalgae having a place with 2 distinct genera Spirulina and Arthrospira that comprises of around 15 species (Siva Kiran et al., 2015). In numerous nations of Africa, Spirulina used as food that full of protein and is accumulated from basic water, dried and eaten (Vedi et al., 2013). 70% of spirulina is protein in addition to carotenoid, omega 3 & 6, glycolipids, polysaccharides, sulfolipids, Gamma Linolenic Acid (GLA), provitamins; and many minerals as potassium, calcium, magnesium, iron, manganese, selenium and zinc (Khan et al., 2005). Pre-clinical and clinical assessments recommend that spirulina has certain helpful impacts as in decline in blood cholesterol, weight, radiation insurance, and nephrotoxicity (Deng and Chow, 2010; Siva Kiran et al., 2015).
Nanotechnology has an immense scope of utilization in conclusion, drug conveyance, food industry, ecological cleanup, paints, hardware, sportsbeauty care products, and sunscreens (Nel et al., 2006; El-Masry et al., 2020b). Nanoparticles (NPs) are materials with a size scope of roughly 1-100 nm (Altwaijry et al., 2020, 2021). The little size of these particles gives an expanded surface region and incites interesting and explicit physicochemical qualities like high conductivity, and compound reactivity contrasted with mass materials (Alotaibi et al., 2021). Along these lines; this exploration mean to portray the antineoplastic action of spirulina nanoparticles against Ehrlich tumor in the solid forms prompted adjustment in liver functions, oxidative stress, tumor markers, monooxygenase and DNA damage in female mice.