Author Contributions: Dr. Zhao had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Drs Yang, Liu and Zheng are co-first authors, contributed equally to the work.
Concept and design: Drs.Yang, Liu, Zheng and Zhao.
Acquisition, analysis, or interpretation of data: Wang and Zhang.
Drafting of the manuscript: Yang, Liu, Zheng and Zhao.
Critical revision of the manuscript for important intellectual content: Wang, Liu and Zhao.
Statistical analysis: Yang, Liu, Zheng and Zhao.
Supervision: Dr. Dongchi Zhao
Conflict of Interest Disclosures: None reported.
Funding/Support: This work was supported by the Science and Technology Department of Hubei Province (grant number: 2019-nCoV. No.2020FCA011).
Disclaimer: The opinions expressed herein reflect the collective views of the coauthors.
Acknowledgment: All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
The present study was registered as a clinical study in the Chinese Clinical Trial Registry(ChiCTR-ORC-16008872) and the Institutional Review Board of Zhongnan Hospital of Wuhan University approved the study(approval no. 2015019), and all guardians signed informed consents that the participates consented to participate and/or publish.