Temperature-responsive polymers are smart materials due to responding to change in surrounding temperature and are applicable for different applications. Here, we prepared the smart rubber from epoxidized natural rubber (ENR) latex, N-vinylcaprolactam (NVCL) as monomer, poly(vinyl alcohol) (PVA) as a surfactant and potassium persulfate (KPS) as free radical initiator. The temperature responsiveness of the grafted copolymers was investigated using water swelling and compared with that of pure ENR. The lower critical solution temperature (LCST) of the grafted copolymer was found to be in the range 20-40 ˚C whereas the ENR was not responsive to temperature. The temperature-responsiveness of the grafted copolymer near human body temperature can be utilized to be fabricated as biomedical materials. Based on this study, the temperature-responsive ENR-graft-NVCL would potentially be used as a novel responsive rubber-based material in various applications.