1. Jensen, B. et al. The hypertrabeculated (noncompacted) left ventricle is different from the ventricle of embryos and ectothermic vertebrates. Biochim. Biophys. Acta - Mol. Cell Res. 1863, 1696–1706 (2016).
2. Anderson, R. H. et al. Key Questions Relating to Left Ventricular Noncompaction Cardiomyopathy: Is the Emperor Still Wearing Any Clothes? Can. J. Cardiol. 33, 747–757 (2017).
3. Petersen, S. E. et al. Left Ventricular Non-Compaction - Insights From Cardiovascular Magnetic Resonance Imaging. J. Am. Coll. Cardiol. 46, 101–105 (2005).
4. de la Chica, J. A. et al. Association Between Left Ventricular Noncompaction and Vigorous Physical Activity. J. Am. Coll. Cardiol. 76, 1723–1733 (2020).
5. Oechslin, E. N., Attenhofer Jost, C. H., Rojas, J. R., Kaufmann, P. A. & Jenni, R. Long-term follow-up of 34 adults with isolated left ventricular noncompaction: A distinct cardiomyopathy with poor prognosis. J. Am. Coll. Cardiol. 36, 493–500 (2000).
6. Peters, F. et al. Clinical outcomes in patients with isolated left ventricular noncompaction and heart failure. J. Card. Fail. 20, 709–715 (2014).
7. Kovacevic-Preradovic, T. et al. Isolated left ventricular noncompaction as a cause for heart failure and heart transplantation: a single center experience. Cardiology 112, 158–64 (2009).
8. Zemrak, F. et al. The relationship of left ventricular trabeculation to ventricular function and structure over a 9.5-year follow-up: The MESA study. J. Am. Coll. Cardiol. 64, 1971–1980 (2014).
9. Chuang, M. L. et al. Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on CMR measures of LV anatomy and function. JACC Cardiovasc. Imaging 5, 1115–1123 (2012).
10. Tobita, K., Schroder, E. A., Tinney, J. P., Garrison, J. B. & Keller, B. B. Regional passive ventricular stress-strain relations during development of altered loads in chick embryo. Am. J. Physiol. Circ. Physiol. 282, H2386–H2396 (2002).
11. Chin, T. K., Perloff, J. K., Williams, R. G., Jue, K. & Mohrmann, R. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation 82, 507–513 (1990).
12. Towbin, J. A. & Jefferies, J. L. Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism. Circ. Res. 121, 838–854 (2017).
13. Bartram, U., Bauer, J. & Schranz, D. Primary noncompaction of the ventricular myocardium from the morphogenetic standpoint. Pediatr. Cardiol. 28, 325–332 (2007).
14. Gati, S. et al. Reversible De Novo Left Ventricular Trabeculations in Pregnant Women. Circulation 130, 475–483 (2014).
15. Hussein, A., Karimianpour, A., Collier, P. & Krasuski, R. A. Isolated Noncompaction of the Left Ventricle in Adults. J. Am. Coll. Cardiol. 66, 578–585 (2015).
16. Finsterer, J., Stöllberger, C. & Towbin, J. A. Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors. Nat. Rev. Cardiol. 14, 224–237 (2017).
17. Choquet, C. et al. Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy. PLOS Genet. 1–31 (2018).
18. Wilsbacher, L. & McNally, E. M. Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure. Annu. Rev. Pathol. Mech. Dis. 11, 395–419 (2016).
19. Faber, J. W., D’Silva, A., Christoffels, V. M. & Jensen, B. Lack of morphometric evidence for ventricular compaction in humans. J. Cardiol. (2021). doi:10.1016/j.jjcc.2021.03.006
20. Jenni, R., Oechslin, E., Schneider, J., Attenhofer Jost, C. & Kaufmann, P. A. Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart 86, 666–71 (2001).
21. Jacquier, A. et al. Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction. Eur. Heart J. 31, 1098–1104 (2010).
22. Sizarov, A., Anderson, R. H., Christoffels, V. M. & Moorman, A. F. M. M. Three-dimensional and molecular analysis of the venous pole of the developing human heart. Circulation 122, 798–807 (2010).
23. Sizarov, A. et al. Three-dimensional and molecular analysis of the arterial pole of the developing human heart. J. Anat. 220, 336–349 (2012).
24. Jensen, B., van der Wal, A. C., Moorman, A. F. M. & Christoffels, V. M. Excessive trabeculations in noncompaction do not have the embryonic identity. Int. J. Cardiol. 227, 325–330 (2017).
25. Moorman, A. F. M., Houweling, A. C., de Boer, P. A. J. & Christoffels, V. M. Sensitive Nonradioactive Detection of mRNA in Tissue Sections: Novel Application of the Whole-mount In Situ Hybridization Protocol. J. Histochem. Cytochem. 49, 1–8 (2001).
26. Miranda-Silva, D. et al. Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol. 228, 1–17 (2020).
27. Van der Velden, J. et al. Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins. Cardiovasc. Res. 57, 37–47 (2003).
28. Rychterova, V. Principle of growth in thickness of the heart ventricular wall in the chick embryo. Folia Morphol (Praha) 19, 262–272 (1971).
29. Palermo, J., Gulick, J., Colbert, M., Fewell, J. & Robbins, J. Transgenic Remodeling of the Contractile Apparatus in the Mammalian Heart. Circ. Res. 78, 504–509 (1996).
30. Bayeva, M., Gheorghiade, M. & Ardehali, H. Mitochondria as a therapeutic target in heart failure. J. Am. Coll. Cardiol. 61, 599–610 (2013).
31. Oechslin, E. & Jenni, R. Left ventricular non-compaction revisited: a distinct phenotype with genetic heterogeneity? Eur. Heart J. 32, 1446–1456 (2011).
32. de Bakker, B. S. et al. An interactive three-dimensional digital atlas and quantitative database of human development. Science 354, aag0053 (2016).
33. Christoffels, V. M. et al. Chamber formation and morphogenesis in the developing mammalian heart. Dev. Biol. 223, 266–278 (2000).
34. Rhee, S. et al. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat. Commun. 9, 368 (2018).
35. Hu, Y. et al. Identification of cardiac hemo-vascular precursors and their requirement of sphingosine-1-phosphate receptor 1 for heart development. Sci. Rep. 7, 1–13 (2017).
36. Luxán, G. et al. Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat. Med. 19, 193–201 (2013).
37. Estes, E. H., Dalton, F. M., Entman, M. L., Dixon, H. B. & Hackel, D. B. The anatomy and blood supply of the papillary muscles of the left ventricle. Am. Heart J. 71, 356–362 (1966).
38. Wearn, J. T. THE EXTENT OF THE CAPILLARY BED OF THE HEART. J. Exp. Med. 47, 273–290 (1928).
39. Sizarov, A. et al. Formation of the building plan of the human heart: Morphogenesis, growth, and differentiation Supplement. Options 123, 1–5 (2011).
40. de Boer, B. A. J., van den Berg, G., de Boer, P. A. J., Moorman, A. F. M. & Ruijter, J. M. Growth of the developing mouse heart: An interactive qualitative and quantitative 3D atlas. Dev. Biol. 368, 203–213 (2012).
41. Moorman, A. F. M. et al. Presence of functional sarcoplasmic reticulum in the developing heart and its confinement to chamber myocardium. Dev. Biol. 223, 279–290 (2000).
42. Meyer, H. V et al. Genetic and functional insights into the fractal structure of the heart. Nature 584, 589–594 (2020).
43. Seymour, R. S. & Blaylock, A. J. The Principle of Laplace and Scaling of Ventricular Wall Stress and Blood Pressure in Mammals and Birds. Physiol. Biochem. Zool. 73, 389–405 (2000).
44. Weir-McCall, J. R. et al. Left Ventricular Noncompaction: Anatomical Phenotype or Distinct Cardiomyopathy? J. Am. Coll. Cardiol. 68, 2157–2165 (2016).
45. Ivanov, A. et al. Prevalence and prognostic significance of left ventricular noncompaction in patients referred for cardiac magnetic resonance imaging. Circ. Cardiovasc. Imaging 10, 1–10 (2017).
46. Sedmera, D., Pexieder, T., Vuillemin, M., Thompson, R. P. & Anderson, R. H. Developmental patterning of the myocardium. Anat. Rec. 258, 319–337 (2000).
47. Faber, J. W., Hagoort, J., Moorman, A. F. M., Christoffels, V. M. & Jensen, B. Quantified growth of the human embryonic heart. Biol. Open bio.057059 (2021). doi:10.1242/bio.057059
48. Papavassiliu, T. et al. Effect of endocardial trabeculae on left ventricular measurements and measurement reproducibility at cardiovascular MR imaging. Radiology 236, 57–64 (2005).
49. Grothoff, M. et al. Value of cardiovascular MR in diagnosing left ventricular non-compaction cardiomyopathy and in discriminating between other cardiomyopathies. Eur. Radiol. 22, 2699–2709 (2012).