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Can Sex be A Predictor of Survival and Treatment Benefit in T1-3N0M0 colorectal Cancer Patients? A Population-Based Analysis
Bin Ma
Liaoning Cancer Institute and Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0727-4536
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Our aim was to assess predictive effect of sex on survival and treatment benefit of T1-3N0M0 CRC.
Methods: This study population was assembled from the SEER dataset. Between 2004 and 2016, patients diagnosed with malignant primary CRC who underwent primary tumour resection were included.
Results: First, we found that females had better OS than males and that sex could be an independent factor of survival in T1-3N0M0 colon cancer (regardless of right/left-sided tumour) and T1-2N0M0 rectal cancer (each HR<1, each P<0.05). In addition, though a significant OS benefit was not observed in T3N0M0 rectal cancer in the overall analysis (P=0.183), females benefited more than males among T3N0M0 rectal cancer patients who underwent postoperative chemotherapy (P<0.001). However, there was no significant OS difference between male and femaleT3N0M0 rectal cancer patients among those who did not receive postoperative chemotherapy (P=0.634). In subgroup analyses of T3N0M0 patients, a similar tendency of survival and the effect of postoperative chemotherapy were observed regardless of whether preoperative radiotherapy was performed. Furthermore, we found that females had a survival benefit over males at all ages, among patients of the white race and among T1-T3 adenocarcinoma CRC patients (each HR<1, each P<0.001).
Conclusion: Sex was proven to be an independent prognostic factor in T1-3N0M0 colon cancer and T1-2N0M0 rectal cancer. Females are more likely to benefit from postoperative chemotherapy than males with T3N0M0 rectal cancer. Our research suggests that sex could be considered a factor in practical clinical treatment and prognosis evaluation for T1-3N0M0 rectal cancer.
Keywords
Colorectal cancer, Sex, Overall survival, Radiotherapy, SEER dataset
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Research
Can Sex be A Predictor of Survival and Treatment Benefit in T1-3N0M0 colorectal Cancer Patients? A Population-Based Analysis
Bin Ma
Liaoning Cancer Institute and Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-0727-4536
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 19 Aug, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cancer Biology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Our aim was to assess predictive effect of sex on survival and treatment benefit of T1-3N0M0 CRC.
Methods: This study population was assembled from the SEER dataset. Between 2004 and 2016, patients diagnosed with malignant primary CRC who underwent primary tumour resection were included.
Results: First, we found that females had better OS than males and that sex could be an independent factor of survival in T1-3N0M0 colon cancer (regardless of right/left-sided tumour) and T1-2N0M0 rectal cancer (each HR<1, each P<0.05). In addition, though a significant OS benefit was not observed in T3N0M0 rectal cancer in the overall analysis (P=0.183), females benefited more than males among T3N0M0 rectal cancer patients who underwent postoperative chemotherapy (P<0.001). However, there was no significant OS difference between male and femaleT3N0M0 rectal cancer patients among those who did not receive postoperative chemotherapy (P=0.634). In subgroup analyses of T3N0M0 patients, a similar tendency of survival and the effect of postoperative chemotherapy were observed regardless of whether preoperative radiotherapy was performed. Furthermore, we found that females had a survival benefit over males at all ages, among patients of the white race and among T1-T3 adenocarcinoma CRC patients (each HR<1, each P<0.001).
Conclusion: Sex was proven to be an independent prognostic factor in T1-3N0M0 colon cancer and T1-2N0M0 rectal cancer. Females are more likely to benefit from postoperative chemotherapy than males with T3N0M0 rectal cancer. Our research suggests that sex could be considered a factor in practical clinical treatment and prognosis evaluation for T1-3N0M0 rectal cancer.
Figure 1
Figure 2
Figure 3
Figure 4